Efficacy of Interspinous Process Fusion with Recombinant Human Bone Morphogenetic Protein-2 Delivered by a Synthetic Polymer and β-Tricalcium Phosphate
| Project/Area Number |
20890196
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Osaka City University |
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Principal Investigator |
TOYODA Hiromitsu Osaka City University, 医学部大学院・医学研究科, 病院講師 (50514238)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
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| Keywords | 骨形成蛋白 / 合成ポリマー / リン酸カルシウム / 脊椎 / 薬物伝導系 |
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| Research Abstract |
Regular spinal interbody fusion and posterolateral fusion involve the use of large incisions, dissection, and partial transection of the paravertebral muscle to expose the posterior spine. On the other hand, the approach to perform an interspinous process fusion involves only muscular stripping and preserves almost all structural components of the spine. If interspinous process fusion by use of Bone morphogenetic proteins (BMPs) is successfully achieved, it could reduce the axial compressive load on the vertebral column. This method would be one of the less morbid surgical options for treatment of lumbar disorders. In this study, we attempted to achieve an interspinous process fusion and evaluate its efficacy in experimental rabbit models by using a delivery system for recombinant human (rh) BMP-2. We achieved solid interspinous process fusion in experimental rabbit models by implanting a biodegradable bone-inducing implant composed of 60μg of rhBMP-2 within a period of 8 weeks. The efficacy of the interspinous process fusion was indicated by the stabilization of the spinal column and decrease in the intradiscal pressure due to axial compressive loading.
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] External hip protectors are effective for the elderly with higher-than-average risk factors for hip fractures.2009
Author(s)
Koike T, Orito Y, Toyoda H, Tada M, Sugama R, Hoshino M, Nakao Y, Kobayashi S, Kondo K, Hirota Y, Takaoka K
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Journal Title
Osteoporos Int 20(9)
Pages: 1613-20
Related Report
Peer Reviewed
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[Journal Article] External hip protectors are effective for the elderly with higher-than-average risk factors for hip fractures.2009
Author(s)
Koike T, Orito Y, Toyoda H, Tada M, Sugama R, Hoshino M, Nakao Y, Kobayashi S, Kondo K, Hirota Y, Takaoka K.
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Journal Title
Osteoporos Int 20(9)
Pages: 1613-1620
Related Report
Peer Reviewed
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