| Project/Area Number |
20890198
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
KOHSAKA Akira Wakayama Medical University, 医学部, 講師 (00458051)
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| Research Collaborator |
MAEDA Masanobu 和歌山県立医科大学, 医学部, 教授 (80181593)
WAKI Hidefumi 和歌山県立医科大学, 医学部, 講師 (50274957)
CUI He 和歌山県立医科大学, 医学部, 博士研究員 (50551371)
BHUIYAN Mohammad 和歌山県立医科大学, 医学部・大学院
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
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| Keywords | 中枢性血圧調節 / 生体リズム / 体内時計 / 血圧日内リズム / Prokineticn 2 / 延髄孤束核 / 高血圧 / 分子時計 / 中枢性循環調節 / Prokineticin2 |
|---|
| Research Abstract |
The blood pressure rhythm is subject to diurnal variation governed by the circadian clock system. However, little is known about how the circadian system transmits the timing signals to the cardiovascular system. In the present studies, we found that prokineticin 2, a target molecule of the circadian clock, is abundantly expressed in the nucleus tractus solitarius and regulates rhythms and levels of blood pressure in rats.
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