Does direct delivery of nitric oxide synthase improve acute limb ischemia?

Research Project

Project/Area Number	20890199
Research Category	Grant-in-Aid for Young Scientists (Start-up)
Allocation Type	Single-year Grants
Research Field	Thoracic surgery
Research Institution	Wakayama Medical University
Principal Investigator	HATADA Atsutoshi Wakayama Medical University, 医学部, 助教 (70508027)
Project Period (FY)	2008 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000) Fiscal Year 2009: ¥1,404,000 (Direct Cost: ¥1,080,000、Indirect Cost: ¥324,000) Fiscal Year 2008: ¥1,586,000 (Direct Cost: ¥1,220,000、Indirect Cost: ¥366,000)
Keywords	急性動脈閉塞 / 一酸化窒素合成酵素 / 蛋白質療法 / 下肢壊死 / タンパク質導入 / タンパク質治療
Research Abstract	It was successful that direct delivery of nitric oxide synthase into ischemic limb tissue in acute limb ischemia rat model. The type of targeted delivery system presented here should be broadly useful for administering therapeutic proteins to the acute limb ischemia.