| Project/Area Number |
20890203
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Prosthetic dentistry
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
NAKAMOTO Tetsuji Kyushu Dental College, 歯学部, 助教 (30514989)
|
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| Research Collaborator |
KONDO Yusuke 九州歯科大学, 歯学部・大学院
KIDOKORO Manami 九州歯科大学, 歯学部・大学院
MUKAIBOU Taro 九州歯科大学, 歯学部・大学院
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| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
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| Keywords | 唾液腺 / 口腔乾燥症 / イオン / ムスカリン性レセプター / ピロカルピン / セビメリン / 水分泌 |
|---|
| Research Abstract |
Fluid secretion in response to muscarinic agonists was analyzed using a mouse ex vivo submandibular perfusion technique. Lowering the temperature from the body temperature induced less salivation. Also, increasing the osmolarity in perfusion solution caused less fluid secretion. Pharmacological inhibition on channels, receptors and transporters crucial for fluid secretion also inhibited fluid secretion. Ion concentrations in secreted ex vivo saliva turned out their ion compositions were different among hyposalivaiton models. The results suggest that ion concentration analysis might work for identifying the target which causes hyposalivation.
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