A study on oral function of hyposalivation models
Project/Area Number |
20890203
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Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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Allocation Type | Single-year Grants |
Research Field |
Prosthetic dentistry
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Research Institution | Kyushu Dental College |
Principal Investigator |
NAKAMOTO Tetsuji Kyushu Dental College, 歯学部, 助教 (30514989)
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Research Collaborator |
KONDO Yusuke 九州歯科大学, 歯学部・大学院
KIDOKORO Manami 九州歯科大学, 歯学部・大学院
MUKAIBOU Taro 九州歯科大学, 歯学部・大学院
|
Project Period (FY) |
2008 – 2009
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Project Status |
Completed (Fiscal Year 2009)
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Budget Amount *help |
¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
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Keywords | 唾液腺 / 口腔乾燥症 / イオン / ムスカリン性レセプター / ピロカルピン / セビメリン / 水分泌 |
Research Abstract |
Fluid secretion in response to muscarinic agonists was analyzed using a mouse ex vivo submandibular perfusion technique. Lowering the temperature from the body temperature induced less salivation. Also, increasing the osmolarity in perfusion solution caused less fluid secretion. Pharmacological inhibition on channels, receptors and transporters crucial for fluid secretion also inhibited fluid secretion. Ion concentrations in secreted ex vivo saliva turned out their ion compositions were different among hyposalivaiton models. The results suggest that ion concentration analysis might work for identifying the target which causes hyposalivation.
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Report
(3 results)
Research Products
(21 results)
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[Presentation] 低出力パルス超音波が唾液腺分泌に及ぼす影響2009
Author(s)
城所愛美, 近藤祐介, 向坊太郎, 中本哲自, 細川隆司
Organizer
第39回 (社)日本口腔インプラント学会・学術大会,第29回 (社)日本口腔インプラント学会中国・四国支部総会・学術大会併催
Place of Presentation
大阪
Year and Date
2009-09-26
Related Report
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[Presentation] The relationship between fluid secretion and temperature2009
Author(s)
Mukaibou, T., Nakamoto, T., Kondo, Y., Kidokoro, M., Masaki, C., Hosokawa, R.
Organizer
第57回JADR学術大会2nd Meeting of IADR Pan Asian Pacific Federation (PAPF) 1st Meeting of the IADR Asia/Pacific Region (APR)
Place of Presentation
武漢,中華人民共和国
Year and Date
2009-09-23
Related Report
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[Presentation] Purinergic P2X7 receptors mediate ATP-induced saliva secretion by the mouse submandibular gland2009
Author(s)
Nakamoto, T., Brown D.A., Catalan, M.A., Gonzalez-Begne, M, Romanenko, V.G., Melvin, J.E.
Organizer
第11回 外分泌腺国際シンポジウム,徳島09
Place of Presentation
徳島
Year and Date
2009-07-24
Related Report
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[Presentation] Cevimeline and Pilocarpine induced salivation from perfused mouse submandibular gland2009
Author(s)
Kondo, Y., Nakamoto, T., Kidokoro, M., Mukaibou, T., Masaki, C., Hosokawa, R.
Organizer
第11回 外分泌腺国際シンポジウム,徳島09
Place of Presentation
徳島
Year and Date
2009-07-23
Related Report
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[Presentation] Fluid secretion and osmotic effect in mouse submandibular gland2009
Author(s)
Kidokoro, M., Nakamoto, T., Kondo, Y., Mukaibou, T., Masaki, C., Hosokawa, R.
Organizer
第11回 外分泌腺国際シンポジウム,徳島09
Place of Presentation
徳島
Year and Date
2009-07-23
Related Report
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[Presentation] The relationship between fluid secretion and temperature2009
Author(s)
Mukaibou, T., Nakamoto, T., Kondo, Y., Kidokoro, M., Masaki, C., Hosokawa, R.
Organizer
第11回 外分泌腺国際シンポジウム,徳島09
Place of Presentation
徳島
Year and Date
2009-07-23
Related Report
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[Presentation] Cevimeline induced salivation from perfused mouse submandibular glands2009
Author(s)
Kondo, Y., Nakamoto, T., Kidokoro, M., Mukaibou, T., Masaki. C., Hosokawa, R.
Organizer
87th General Session & Exhibition of the IADR
Place of Presentation
Miami, USA
Year and Date
2009-04-03
Related Report
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[Presentation] Cevimeline induced salivation from perfused mouse submandibular glands2009
Author(s)
Kondo, Y., Nakamoto, T., Kidokoro, M., Mukaibou, T., Masaki, C., Hosokawa, R.
Organizer
87th General Session & Exhibition of the IADR
Place of Presentation
Miami, FL, USA
Year and Date
2009-04-02
Related Report
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[Presentation] Purinergic P2X7 receptors mediate ATP-induced saliva secretion by the mouse submandibular gland2009
Author(s)
Nakamoto, T., Brown, D.A., Catalan, M.A., Gonzalez-Begne, M., Romanenko, V.G., Melvin, J.E.
Organizer
第11回外分泌腺国際シンポジウム, 徳島09
Place of Presentation
Tokushima
Related Report
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