| Project/Area Number |
20890204
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Orthodontic/Pediatric dentistry
|
|---|
| Research Institution | Kyushu Dental College |
|---|
Principal Investigator |
FUJITA Yuko Kyushu Dental College, 歯学部, 助教 (90514670)
藤田 優子 (2009) Kyushu Dental College, 歯学部, 助教 (90415670)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥3,224,000 (Direct Cost: ¥2,480,000、Indirect Cost: ¥744,000)
Fiscal Year 2009: ¥1,508,000 (Direct Cost: ¥1,160,000、Indirect Cost: ¥348,000)
Fiscal Year 2008: ¥1,716,000 (Direct Cost: ¥1,320,000、Indirect Cost: ¥396,000)
|
|---|
| Keywords | レプチン / 骨代謝 / 肥満 / 骨粗鬆症 / アディポネクチン / 糖尿病 / 骨密度 / メタボリック症候群 |
|---|
| Research Abstract |
In Japan, obesity-associated disorders arise in mildly to moderately obese children and adolescents. However, relationship between overweight with high cholesterol level and bone fragility are unknown. Furthermore, relationship of serum leptin and adiponectin and bone mass during growing phase are still unclear. The propose of this study is to determine whether diet-induced obesity affects bone tissue quantity and bone strength, or combinations of the two. In addition, we evaluated the possible correlations between bone mineral parameters and leptin and adiponectin. A high-fat diet-induced obesity induced bone fragility of the tibia in the growing mice. In trabecular bone, bone density was decreased by an increase in the number of adipocytes, following a decrease in the cortical bone density in the diet-induced obesity mice. In overall mice, there was a significant inverse correlation between leptin and trabecular bone density and bone cross-sectional area. However, there is a significant positive correlation between cortical bone density and bone cross-sectional area. These results suggested that serum leptin and adiponectin levels were correlated with trabecular and cortical bone density, but these effects in these two sites is regulated differently in the growing mice tibia.
|
