| Project/Area Number |
20890205
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Orthodontic/Pediatric dentistry
|
|---|
| Research Institution | Kyushu Dental College |
|---|
Principal Investigator |
MORIKAWA Kazumasa Kyushu Dental College, 歯学部, 助教 (70514686)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥3,224,000 (Direct Cost: ¥2,480,000、Indirect Cost: ¥744,000)
Fiscal Year 2009: ¥1,508,000 (Direct Cost: ¥1,160,000、Indirect Cost: ¥348,000)
Fiscal Year 2008: ¥1,716,000 (Direct Cost: ¥1,320,000、Indirect Cost: ¥396,000)
|
|---|
| Keywords | 歯学 / 骨吸収 / 破骨細胞 / 細胞接着 / 萌出 / 歯槽骨 / ゼストスポンギンC / イノシトール1,4,5-三リン酸受容体 |
|---|
| Research Abstract |
In this study the influence on the osteoclasts was examined by using the inositol 1,4,5-trisphosphate receptors (IP_3Rs) antagonist xestospongin-C (XSC) to do further analysis of the relation with the cellular adhesion in the osteoclasts of IP_3R type III (IP_3R-III). In the presence of XSC, shrinkage of osteoclasts and a decrease in the coexistence of IP_3R-III and podosomes, the adhesion area of osteoclasts were verified. It can be suggested that IP_3R-III accomplishes a key role in the adjustment of the actin cytoskeleton in podosomes.
|
