| Project/Area Number |
20890206
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Health Sciences University of Hokkaido |
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Principal Investigator |
OSHIMA Nobuhiro Health Sciences University of Hokkaido, 薬学部, 助教 (80508648)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥2,847,000 (Direct Cost: ¥2,190,000、Indirect Cost: ¥657,000)
Fiscal Year 2009: ¥1,326,000 (Direct Cost: ¥1,020,000、Indirect Cost: ¥306,000)
Fiscal Year 2008: ¥1,521,000 (Direct Cost: ¥1,170,000、Indirect Cost: ¥351,000)
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| Keywords | がん / アイソトープ内用療法 / 薬物動態制御 / 放射性医薬品 / オクトレオチド / 腎臓 / 負電荷導入 / オクトレオチ |
|---|
| Research Abstract |
Recently, cancer treatment using radioisotope(RI)-labeled peptides have received attention as one of radiation therapies. But, their clinical application is difficult because of their high accumulation of radioactivity in kidney. On the other hand, it was revealed that the renal accumulation can be reduced by introducing anion charge to peptide moiety. In this study, therefore, I aimed to develop RI-labeled peptides of reduced renal radioactivity with maintaining the affinity for cancer cells by introduction of anion charge. As a result, I found a new RI-labeled peptide having equivalent affinity for cancer cells compared with non-modified RI-labeled peptides.
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