Mechanism for novel sterols induced anchorage-independent cancer cell death

Research Project

Project/Area Number	20890207
Research Category	Grant-in-Aid for Young Scientists (Start-up)
Allocation Type	Single-year Grants
Research Field	Biological pharmacy
Research Institution	Iwate Medical University
Principal Investigator	TANAKA Aro Iwate Medical University, 薬学部, 助手 (60509040)
Project Period (FY)	2008 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000) Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
Keywords	癌 / シグナル伝達 / anoikis / P38mapk / Rho / 薬学 / p38MAPK / 酸化ステロール / OSBP
Research Abstract	Anicequol is a terpenoid derived from fungus. We aimed the elucidation of the mechanism underlying anicequol induced anoikis in colon cancer cell lines DLD1 and HT29. As a result, we showed that the p38MAPK pathway is associated with anicequol induced anoikis. In addition, Rho-kinase inhibitor Y27632 inhibited anicequol induced anoikis, suggesting that p38MAPK pathway links Rho pathway.

Report

(3 results)