Mechanism for novel sterols induced anchorage-independent cancer cell death
| Project/Area Number |
20890207
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Iwate Medical University |
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Principal Investigator |
TANAKA Aro Iwate Medical University, 薬学部, 助手 (60509040)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
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| Keywords | 癌 / シグナル伝達 / anoikis / P38mapk / Rho / 薬学 / p38MAPK / 酸化ステロール / OSBP |
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| Research Abstract |
Anicequol is a terpenoid derived from fungus. We aimed the elucidation of the mechanism underlying anicequol induced anoikis in colon cancer cell lines DLD1 and HT29. As a result, we showed that the p38MAPK pathway is associated with anicequol induced anoikis. In addition, Rho-kinase inhibitor Y27632 inhibited anicequol induced anoikis, suggesting that p38MAPK pathway links Rho pathway.
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Report
(3 results)
Research Products
(4 results)
