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Mechanism for novel sterols induced anchorage-independent cancer cell death

Research Project

Project/Area Number 20890207
Research Category

Grant-in-Aid for Young Scientists (Start-up)

Allocation TypeSingle-year Grants
Research Field Biological pharmacy
Research InstitutionIwate Medical University

Principal Investigator

TANAKA Aro  Iwate Medical University, 薬学部, 助手 (60509040)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
Keywords癌 / シグナル伝達 / anoikis / P38mapk / Rho / 薬学 / p38MAPK / 酸化ステロール / OSBP
Research Abstract

Anicequol is a terpenoid derived from fungus. We aimed the elucidation of the mechanism underlying anicequol induced anoikis in colon cancer cell lines DLD1 and HT29. As a result, we showed that the p38MAPK pathway is associated with anicequol induced anoikis. In addition, Rho-kinase inhibitor Y27632 inhibited anicequol induced anoikis, suggesting that p38MAPK pathway links Rho pathway.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (4 results)

All 2008

All Journal Article (4 results) (of which Peer Reviewed: 4 results)

  • [Journal Article] The ABCA1 Q597R mutant undergoes trafficking from the ER upon ER stress2008

    • Author(s)
      Tanaka AR, Kano F, Ueda K, Murata M
    • Journal Title

      Biochem Biophys Res Commun 369(4)

      Pages: 1174-8

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Formation of cholesterol-enriched structures by aberrant intracellular accumulation of ATP-binding cassette transporter A12008

    • Author(s)
      Tanaka AR, Kano F, Yamamoto A, Ueda K, Murata M
    • Journal Title

      Genes Cells 13(8)

      Pages: 889-904

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The ABCAl Q597R mutant undergoes trafficking from the ER upon ER stress.2008

    • Author(s)
      Tanaka AR, et al
    • Journal Title

      Biochem Biophys Res Commun. 369(4)

      Pages: 1174-1178

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Formation of cholesterol-enriched structures by aberrant intracellular accumulation of ATP-binding cassette transporter AI2008

    • Author(s)
      Tanaka AR, et al
    • Journal Title

      Genes Cells. 13(8)

      Pages: 889-904

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed

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Published: 2008-04-01   Modified: 2016-04-21  

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