Search for regulatory factors controlling intracellular localization of P-glycoprotein
| Project/Area Number |
20890212
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied pharmacology
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| Research Institution | Takasaki University of Health and Welfare |
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Principal Investigator |
KANO Takashi Takasaki University of Health and Welfare, 薬学部, 助手 (70509257)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
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| Keywords | P-タンパク / 調節因子 / ERMタンパク / 癌多剤耐性 / P-糖タンパク |
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| Research Abstract |
ERM proteins (ezrin-radixin-moesin) are a closely related family of membrane-cytoskeleton crosslinkers. In this study, we identified ezrin as one of the transcriptional factors of P-glycoprotein (P-gp) and radixin as one of the post-translational factors of P-gp. The function of P-gp does not correlate well with the mRNA level. Therefore, we hypothesize that radixin act as a potent regulatory factor for P-gp function.
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Report
(3 results)
Research Products
(2 results)
