Search for regulatory factors controlling intracellular localization of P-glycoprotein

Research Project

Project/Area Number	20890212
Research Category	Grant-in-Aid for Young Scientists (Start-up)
Allocation Type	Single-year Grants
Research Field	Applied pharmacology
Research Institution	Takasaki University of Health and Welfare
Principal Investigator	KANO Takashi Takasaki University of Health and Welfare, 薬学部, 助手 (70509257)
Project Period (FY)	2008 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000) Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
Keywords	P-タンパク / 調節因子 / ERMタンパク / 癌多剤耐性 / P-糖タンパク
Research Abstract	ERM proteins (ezrin-radixin-moesin) are a closely related family of membrane-cytoskeleton crosslinkers. In this study, we identified ezrin as one of the transcriptional factors of P-glycoprotein (P-gp) and radixin as one of the post-translational factors of P-gp. The function of P-gp does not correlate well with the mRNA level. Therefore, we hypothesize that radixin act as a potent regulatory factor for P-gp function.

Report

(3 results)