| Project/Area Number |
20890216
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Pathological medical chemistry
|
|---|
| Research Institution | Keio University |
|---|
Principal Investigator |
KANEKURA Kohsuke Keio University, 医学部, 助教 (10508568)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
|
|---|
| Keywords | ALS / UPR / VAPB / ER stress |
|---|
| Research Abstract |
The novel ALS-causative gene, VAPB is involved in unfolded protein response, a physiological signal against endoplasmic reticulum (ER) stress. We investigated VAPB function in detail, and demonstrated that wt-VAPB triggers IRE1 to enhance expression of ER chaperons but it suppress PERK pathway. On the other hand, ALS-causative mutant VAPB dominant negatively suppresses wt-VAPB function and triggers PERK pathway, resulting in upregulation of cytotoxic transcription factor CHOP.
|
