Proteomics Research about tumor promotion activity of polycyclic aromatic compounds

Research Project

Project/Area Number	20890217
Research Category	Grant-in-Aid for Young Scientists (Start-up)
Allocation Type	Single-year Grants
Research Field	Environmental pharmacy
Research Institution	Juntendo University
Principal Investigator	MISAKI Kentaro Juntendo University, 大学院・医学研究科, 博士研究員 (40468591)
Project Period (FY)	2008 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000) Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
Keywords	発ガンプロモーション活性 / 多環芳香族化合物類 / プロテオミクス / シグナル伝達 / 遺伝子 / 環境 / 衛生
Research Abstract	Benzo[k]fluoranthene (B[k]FA), benzo[b]fluoranthene (B[b]FA) and benzopyrenone (BPO) showed significantly high promoting activity among 20 polycyclic aromatic compounds. It is suggested that AhR and reactive oxygen species (ROS) contribute to this activity for B[b]FA and B[k]FA, and ROS for BPO. In microarray analysis for B[k]FA, the increase of AhR-related mRNA and the change of several mRNAs were found. It is scheduled to identify proteins associated with promotion activity and elucidate the activity mechanism for these compounds.

Report

(3 results)