Analysis of microsomal prostaglandin E synthase (mPGES-1) in chemical carcinogen-induced colon carcinogenesis
Project/Area Number |
20890220
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Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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Allocation Type | Single-year Grants |
Research Field |
Biological pharmacy
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Research Institution | Showa University |
Principal Investigator |
KAMEI Daisuke Showa University, 薬学部, 助教 (80515651)
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Project Period (FY) |
2008 – 2009
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Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
|
Keywords | PGE合成酵素 / mPGES-1 / 発がん / 遺伝子欠損マウス / PGE2 |
Research Abstract |
We aimed at the possibility of microsomal prostaglandin E synthase-1 (mPGES-1), which was last synthase of PGE_2, as new therapeutic target of cancer. In this study, using various mPGES-1 gene modification mice, we analyzed the azoxymethane-induced colon tumorigenesis model. As a result, it was found that mPGES-1 contributed to initiation, promotion and progression of colorectal cancer as an exacerbation factor. This study suggested the possibility that inhibition of mPGES-1 was useful as an anticancer therapy of new mechanism of action.
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Report
(3 results)
Research Products
(23 results)
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[Journal Article] Microsomal prostaglandin E synthase-1 in both cancer cells and hosts contributes to tumour growth, invasion and metastasis.2009
Author(s)
Kamei D, Murakami M, Sasaki Y, Nakatani Y, Majima M, Ishikawa Y, Ishii T, Uematsu S, Akira S, Hara S, Kudo I.
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Journal Title
Biochem J. 425
Pages: 361-71
Related Report
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[Journal Article] Microsomal prostaglandin E synthase-1 in both cancer cells and hosts contributes to tumour growth, invasion and metastasis2009
Author(s)
Kamei D, Murakami M, Sasaki Y, Nakatani Y, Majima M, Ishikawa Y, Ishii T, Uematsu S, Akira S, Hara S, Kudo I.
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Journal Title
Biochemical Journal 425
Pages: 361-371
Related Report
Peer Reviewed
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[Journal Article] Association of microsomal prostaglandin E synthase 1 deficiency with impaired fracture healing, but not with bone loss or osteoarthritis, in mouse models of skeletal disorders.2008
Author(s)
Yamakawa K, Kamekura S, Kawamura N, Saegusa M, Kamei D, Murakami M, Kudo I, Uematsu S, Akira S, Chung UI, Nakamura K, Kawaguchi H.
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Journal Title
Arthritis Rheum. 58
Pages: 172-83
Related Report
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