| Project/Area Number |
20890220
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
|---|
| Research Field |
Biological pharmacy
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|---|
| Research Institution | Showa University |
|---|
Principal Investigator |
KAMEI Daisuke Showa University, 薬学部, 助教 (80515651)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
|
|---|
| Keywords | PGE合成酵素 / mPGES-1 / 発がん / 遺伝子欠損マウス / PGE2 |
|---|
| Research Abstract |
We aimed at the possibility of microsomal prostaglandin E synthase-1 (mPGES-1), which was last synthase of PGE_2, as new therapeutic target of cancer. In this study, using various mPGES-1 gene modification mice, we analyzed the azoxymethane-induced colon tumorigenesis model. As a result, it was found that mPGES-1 contributed to initiation, promotion and progression of colorectal cancer as an exacerbation factor. This study suggested the possibility that inhibition of mPGES-1 was useful as an anticancer therapy of new mechanism of action.
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