The analyses of the function of the axon guidance molecules in the filial imprinting of chick

• Project/Area Number: 20890226
• Research Category: Grant-in-Aid for Young Scientists (Start-up)
• Allocation Type: Single-year Grants
• Research Field: Biological pharmacy
• Research Institution: Teikyo University
• Principal Investigator: TAIRA Ikuko Teikyo University, 薬学部, 助教 (60453693)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
• Keywords: 刻印付け / 神経軸索ガイダンス因子 / 大脳 / in vivo遺伝子導入 / ニワトリ / 遺伝子発現

Research Abstract

We analyzed the gene-expression of Netrin-1 using the brain of newly hatched chick. As the result, we identified the Intermediate Medial Hyperpallium Apicale (IMHA) as the novel region related to filial imprinting.
When the vector for the expression of microRNA besed on the sequence of microtubule-associated protein (MAP2) gene introduced to the region related to filial imprinting, endogenious MAP2 protein was decreased, and memory formation was inhibited during filial imprinting.

Research Products

• [Journal Article] Suppression of the ecdysteroid-triggered growth arrest by a novel Drosophila membrane steroid binding protein (2009)
  • Author(s): Fujii-Taira, I., Yamaguchi, S., Iijima, R., Natori, S., Homma, K.J.
  • Journal Title: FEBS Lett. 583 Pages: 655-60
  • Peer Reviewed
• [Journal Article] Suppression of the ecdysteroid-triggered growth arrest by a novel Drosohila membrane steroid bindine urotein. (2009)
  • Author(s): Fujii-Taira I, et al.
  • Journal Title: FEBS Lett. 583(4) Pages: 655-660
  • Peer Reviewed
• [Journal Article] Gene expression profile in cerebrum in the filial imprinting of domestic chicks (Gallus gallus domesticus) (2008)
  • Author(s): Yamaguchi S., Fujii-Taira I, Katagiri S., Izawa E., Fujimoto Y., Takeuchi H., Takano T., Matsushima T., Homma K.J.
  • Journal Title: Brain Res. Bull. 76 Pages: 275-281
  • Peer Reviewed
• [Journal Article] Up-regulation of microtubule-associated protein 2 accompanying the filial imprinting of domestic chicks (Gallus gallus domesticus) (2008)
  • Author(s): Yamaguchi S., Fujii-Taira I,, Murakami A., Hirose N., Aoki N., Izawa E., FujimotoY., Takano T., Matsushima T., Homma K.J.
  • Journal Title: Brain Res. Bull. 76 Pages: 282-288
  • Peer Reviewed
• [Journal Article] The extracellular adenosine deaminase growth factor, ADGF/CECR1, plays a role in Xenopus embryogenesis via the adenosine/P1 receptor. (2008)
  • Author(s): Iijima R., Kunieda T., Yamaguchi S., Kamigaki H., Fujii-Taira I, Sekimizu K., Kubo T., Nator, S., Homma K.J.
  • Journal Title: J. Biol. Chem. 283 Pages: 2255-2264
  • Peer Reviewed
• [Journal Article] The extracellular adenosine deaminase growth factor, ADGF/CECR1, plays a role in Xenopus embryogenesis via the adenosine/P1 receptor (2008)
  • Author(s): Iijima, R., et al.
  • Journal Title: J. Biol. Chem. 283 Pages: 2255-2264
  • Peer Reviewed
• [Journal Article] Gene expression profile in cerebrum in the filial imprinting of domestic chick (Gallus gallus domesticus) (2008)
  • Author(s): Yamaguchi, S, et al
  • Journal Title: Brain Res. Bull. 76 Pages: 275-281
  • Peer Reviewed
• [Journal Article] Up-regulation of microtubule-associated protein 2 accompanying the filial imprinting of domestic chick (Gallus gallus domesticus) (2008)
  • Author(s): Yamaguchi, S., et al.
  • Journal Title: Brain Res. Bull. 76 Pages: 282-288
  • Peer Reviewed
• [Presentation] ニワトリVSPはホスファターゼ活性の発現によって線維芽細胞の形態変化を引き起こす (2009)
  • Author(s): 平郁子、山口真二、山田マミ、神垣ひろこ、黒川竜紀、岡村康司、本間光一
  • Organizer: 第82回日本生化学会大会
  • Year and Date: 2009-10-24
• [Presentation] ニワトリVSPはホスファターゼ活性の発現によって線維芽細胞の形態変化を引き起こす (2009)
  • Author(s): 平郁子
  • Organizer: 日本生化学会
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2009-10-24
• [Presentation] 鳥類刻印付けの分子基盤の解明 (2008)
  • Author(s): 片桐幸子、山口真二、平郁子、本間光一
  • Organizer: 日本薬学会生物系薬学部会「ファーマ・バイオフォーラム2008」
  • Place of Presentation: 日本薬学会長井記念ホール
  • Year and Date: 2008-11-29
• [Presentation] RNAiによるニワトリヒナ大脳での特異的遺伝子抑圧系の確立 (2008)
  • Author(s): 片桐幸子、広瀬直樹、山口真二、平郁子、藤本康之、高野達哉、松島俊也、本間光一
  • Organizer: 日本薬学会128回大会
• [Remarks]
  • URL: http://www.pharm.teikyo-u.ac.jp/lab/byotai/index.html
• [Remarks]
  • URL: http://www.pharm.teikyo-u.ac.jp/lab/byotai/index.html