| Budget Amount *help |
¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
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| Research Abstract |
Fetal hepatoblasts differentiate into both hepatocytes and cholangiocytes. The precise molecular mechanisms regulating this lineage commitment remain unknown. Sall4 has been shown to be among the regulators of embryogenesis, organogenesis, maintenance of pluripotency, and early embryonic cell fate determinations in ES cells. We here provide their first description in hepatoblasts. Sall4 plays a key role in regulating the lineage segmentation of hepatoblasts, not only inhibiting their differentiation into hepatocytes, but also driving their differentiation toward cholangiocytes.
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