Fluorescence imaging analysis of Na^+/Ca^<2+> exchanger dynamics in myocardial ischemia reperfusion injury
| Project/Area Number |
20890233
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
General pharmacology
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| Research Institution | Toho University |
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Principal Investigator |
NAMEKATA Iyuki Toho University, 薬学部, 講師 (30510309)
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| Research Collaborator |
TANAKA Hikaru 東邦大学, 薬学部, 教授 (40236617)
TAKAHARA Akira 東邦大学, 薬学部, 准教授 (80377481)
KAWANISHI Toru 国立衛生試験所, 部長 (40124383)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
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| Keywords | 心筋 / 虚血再灌流障害 / ナトリウム・カルシウム交換機構 / イメージング / ミトコンドリア / Na^+ / Ca^<2+>交換機構 |
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| Research Abstract |
I studied the regulation of Na^+/Ca^<2+> exchanger (NCX) and mitochondrial dynamics during ischemia-reperfusion in the heart. I concluded that a selective inhibition of plasmalemmal NCX but not mitochondrial NCX appears to be a promising therapeutic strategy for myocardial ischemia-reperfusion injury.
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Report
(3 results)
Research Products
(41 results)
