| Project/Area Number |
20890235
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Drug development chemistry
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| Research Institution | Nihon University |
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Principal Investigator |
IIJIMA Hiroshi Nihon University, 薬学部, 教授 (30465281)
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| Research Collaborator |
SOBU Takayuki 日本大学, 薬学部・大学院・博士前期課程1年
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| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥2,964,000 (Direct Cost: ¥2,280,000、Indirect Cost: ¥684,000)
Fiscal Year 2009: ¥1,261,000 (Direct Cost: ¥970,000、Indirect Cost: ¥291,000)
Fiscal Year 2008: ¥1,703,000 (Direct Cost: ¥1,310,000、Indirect Cost: ¥393,000)
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| Keywords | カテコールアミン / メチルTランスフェラーゼ / COMT / 活性化 / 腎臓 / 心血管系障害 / 代謝 / 酵素 / カテコール |
|---|
| Research Abstract |
There are several reports that suggest the importance of COMT in kidney dysfunction. For example, the progress of kidney dysfunction accompanies sympathetic hyperactivity, the mortality of patient with kidney dysfunction inversely correlates with higher blood concentration of NE, and metabolism or clearance of NE depends on COMT. We intended to establish a new screening method to find out a COMT activator. The initial trial of the activator screening resulted in discovery of compounds with which the enzyme reaction increased approximately 10% at 10 μM.
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