To elcidalate the mechanisms of reactive oxygen spiecis regulats osteoclastogenesis

• Project/Area Number: 20890249
• Research Category: Grant-in-Aid for Young Scientists (Start-up)
• Allocation Type: Single-year Grants
• Research Field: Functional basic dentistry
• Research Institution: Aichi Gakuin University
• Principal Investigator: KONDO Hisataka Aichi Gakuin University, 歯学部, 助教 (40469002)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,042,000 (Direct Cost: ¥2,340,000、Indirect Cost: ¥702,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,482,000 (Direct Cost: ¥1,140,000、Indirect Cost: ¥342,000)
• Keywords: シグナル伝達 / 生体分子 / 遺伝子 / ストレス / 活性酸素種 / 破骨細胞

Research Abstract

The beta-adrenergic agonist stimulate osteoclast differentiation through the beta-adrenergic receptor on osteoblast. We tested whether the beta-adrenergic agonist regulate osteoclast differentiation directory or not. We suggested sympathetic nervous system regulate osteoclast differentiation through reactive oxygen species.

Research Products

• [Journal Article] Oxidative stress and gamma radiation-induced cancellous bone loss with musculoskeletal disuse (2010)
  • Author(s): Kondo Hisataka, Yumoto Kenji, Alwood Josh, Mojarrab Rose, Wang Angela, Almeida Eduardo, Searby Nancy, Limoli Charles L, Globus Ruth.
  • Journal Title: J Appl Physiol. 108(1) Pages: 152-161
  • Peer Reviewed
• [Journal Article] Oxidative stress and gamma radiation-induced cancellous bone loss with musculoskeletal disuse (2010)
  • Author(s): Kondo H, Yumoto K, Alwood JS, Mojarrab R, Wang A, Almeida EA, Searby ND, Limoli CL, Globus RK.
  • Journal Title: Journal of Applied Physiology 108(1) Pages: 152-161
  • Peer Reviewed
• [Journal Article] Total-body irradiation of postpubertal mice with (137)Cs acutely compromises the microarchitecture of cancellous bone and increases osteoclasts (2009)
  • Author(s): Kondo Hisataka、Searby Nancy、Mojarrab Rose、Phillips Jonathan、Alwood Josh、Yumoto Kenji、Almeida Eduardo、Limoli Charles、Globus Ruth
  • Journal Title: Radiat Res 171(3) Pages: 283-289
  • Peer Reviewed
• [Journal Article] 交感神経活動はReactive oxygen species (ROS)を介し破骨細胞分化を促進する (2009)
  • Author(s): 近藤久貴, 戸苅彰史
  • Journal Title: 口腔組織培養学会誌 19(1) Pages: 47-48
• [Journal Article] Total-body irradiation of postpubertal mice with (137)csacutely compromises the microarchitecture of cancellousbone and increases osteoclasts. (2009)
  • Author(s): Kondo H, Searby ND, Mojarrab R, Phillips J, Alwood J, Yumoto K, Almeida EA, Limoli CL, Globus RK.
  • Journal Title: Radiation Research 171(3) Pages: 283-289
  • Peer Reviewed
• [Presentation] 交感神経活動はReactive oxygen species (ROS)を介し破骨細胞分化を促進する (2009)
  • Author(s): 近藤久貴、戸苅彰史
  • Organizer: 第46回口腔組織培養学会
  • Place of Presentation: 昭和大学(東京)
  • Year and Date: 2009-12-05
• [Presentation] 交感神経活動は Reactive oxygen species(ROS)を介し破骨細胞分化を促進する (2009)
  • Author(s): 近藤久貴
  • Organizer: 第46回口腔組織培養学会
  • Place of Presentation: 昭和大学
  • Year and Date: 2009-12-05
• [Presentation] 交感神経は活性酸素種を介し破骨細胞分化を促進する (2009)
  • Author(s): 近藤久貴、戸苅彰史
  • Organizer: 第27回日本骨代謝学会
  • Place of Presentation: 大阪国際会議場(大阪)
  • Year and Date: 2009-07-23
• [Presentation] 交感神経は活性酸素種を介し破骨細胞分化を促進する (2009)
  • Author(s): 近藤久貴
  • Organizer: 第27回日本骨代謝学会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2009-07-23
• [Presentation] The effects of spaceflight on gamma radiosensitivity of bone and cartilage tissues (2008)
  • Author(s): Kondo Hisataka、Togari Akifumi、Domaratskaya Elena、Grigoryan Elenora、Globus Ruth、Searby Nancy、Dvorochkin Natalya、Almeida Eduardo
  • Organizer: Life in space for life on earth
  • Place of Presentation: Angars (France)
  • Year and Date: 2008-06-15
• [Presentation] The effects of spaceflight on gamma radiosensitivity of bone and cartilage tissues (2008)
  • Author(s): Kondo H, Togari A, Domaratskaya E, Grigoryan E, Globus R, Searby G, Dvorochkin N, Almeida E.
  • Organizer: Life in space for life on earth
  • Place of Presentation: Angars, France
  • Year and Date: 2008-06-15