| Project/Area Number |
20890250
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical pharmacy
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| Research Institution | Kinjo Gakuin University |
|---|
Principal Investigator |
KURATA Yoko Kinjo Gakuin University, 薬学部, 助教 (80513928)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥2,652,000 (Direct Cost: ¥2,040,000、Indirect Cost: ¥612,000)
Fiscal Year 2009: ¥1,248,000 (Direct Cost: ¥960,000、Indirect Cost: ¥288,000)
Fiscal Year 2008: ¥1,404,000 (Direct Cost: ¥1,080,000、Indirect Cost: ¥324,000)
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| Keywords | テーラーメイド / 免疫抑制薬 / 薬力学的解析 / Tリンパ球 / フローサイトメトリー / サイトメガロウイルス / 水痘・帯状疱疹ウイルス / CFSE / IL-2 / PCNA / リアルタイムRT-PCR |
|---|
| Research Abstract |
The impact of pretransplant T-cell sensitivity testing using carboxylfluorescein diacetate succinimidyl ester (CFSE)-based flow cytometry was studied in 32 patients with chronic renal failure. There was considerable interindividual variation in the inhibitory effects of cyclosporine (CSA), tacrolimus (TAC), and prednisolone (PRD) but only a small amount of interindividual variation for mycophenolic acid (MPA). Patients with high sensitivity to CSA tended to experience viral reactivation. In addition to post-transplant blood-level monitoring, pretransplant pharmacodynamics could provide useful information on optimal and safe immunosuppressive therapy.
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