HMBA-induced erythroid differentiation decreases sphingosine kinase 1 gene expression of a mouse erythroleukemia cell line
Project/Area Number |
20890251
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Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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Allocation Type | Single-year Grants |
Research Field |
Laboratory medicine
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Research Institution | Chubu University |
Principal Investigator |
SOBUE Sayaka Chubu University, 生命健康科学部, 助手 (50513347)
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Project Period (FY) |
2008 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
|
Keywords | SPHK1 / 赤白血病 / 分子標的療法 / sphingosine kinase 1 / 白血病 / 分化誘導療法 |
Research Abstract |
Friend cell is a mouse erythroleukemia cell line inducible to the erythroid lineage with HMBA. Increased expression of sphingosine kinase 1 (SPHK1), a sphingolipid metabolic enzyme, has been reported in Friend cells. In the current study, we analyzed the mechanism of its SPHK1 overexpression and the sequential changes during HMBA-induced differentiation.
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Report
(3 results)
Research Products
(22 results)
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[Journal Article] ATRA inhibits ceramide kinase transcription in a human neuroblastoma cell line, SH-SY5Y cells : the role of COUP-TFI.2010
Author(s)
Murakami M, Ito H, Hagiwara K, Yoshida K, Sobue S, Ichihara M, Takagi A, Kojima T, Tanaka K, Koizumi-T K, Kyogashima M, Suzuki M, Banno Y, Nozawa Y, Murate T.
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Journal Title
J Neurochem. 112
Pages: 511-520
Related Report
Peer Reviewed
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[Journal Article] GATA-1 and GATA-2 binding to 3' enhancer of WT1 gene is essential for its transcription in acute leukemia and solid tumor cell lines.2009
Author(s)
Furuhata A, Murakami M, Ito H, Gao S, Yoshida K, Sobue S, Kikuchi R, Iwasaki T, Takagi A, Kojima T, Suzuki M, Abe A, Naoe T, Murate T.
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Journal Title
Leukemia. 23
Pages: 1270-1277
Related Report
Peer Reviewed
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[Journal Article] Transcriptional regulation of neutral sphingomyelinase 2 gene expression of a human breast cancer cell line, MCF-7, induced by the anti-cancer drug, daunorubicin.2009
Author(s)
Ito H, Murakami M, Furuhata A, Gao S, Yoshida K, Sobue S, Hagiwara K, Takagi A, Kojima T, Suzuki M, Banno Y, Tanaka K, Tamiya-Koizumi K, Kyogashima M, Nozawa Y, Murate T.
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Journal Title
Biochim Biophys Acta. 1789
Pages: 681-690
Related Report
Peer Reviewed
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[Journal Article] Implications of sphingosine kinase 1 expression level for the cellular sphingolipid rheostat : relevance as a marker for daunorubicin sensitivity of leukemia cells.2008
Author(s)
Sobue S, Nemoto S, Murakami M, Ito H, Kimura A, Gao S, Furuhata A, Takagi A, Kojima T, Nakamura M, Ito Y, Suzuki M, Banno Y, Nozawa Y, Murate T.
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Journal Title
Int J Hematol. 87
Pages: 266-275
Related Report
Peer Reviewed
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[Journal Article] v-Src oncogene product increases sphingosine kinase 1 expression through mRNA stabilization : alteration of AU-rich element-binding proteins.2008
Author(s)
Sobue S, Murakami M, Banno Y, Ito H, Kimura A, Gao S, Furuhata A, Takagi A, Kojima T, Suzuki M, Nozawa Y, Murate T.
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Journal Title
Oncogene. 27
Pages: 6023-6033
Related Report
Peer Reviewed
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