| Project/Area Number |
20890254
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | Suzuka University of Medical Science |
|---|
Principal Investigator |
OHNISHI Shiho Suzuka University of Medical Science, 薬学部, 助手 (80511914)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
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| Keywords | DNA損傷 / 発がん機構 / ras遺伝子 / 8-ニトログアニン / バイオマーカー |
|---|
| Research Abstract |
K-ras mutations are frequently observed in human lung cancer. On the other hand, it is considered that carcinogenesis consists from multi-step process with mutations in more than 10 genes. In this study, 8-nitroguanine and 8-oxodG was apparently formed in lung adenocarcinoma caused by oncogenic K-ras, withoutinflammation. It is reported that 8-nitroguanine and 8-oxodG can cause mutations. These suggest that the accumulation of mutagenic 8-nitroguanine and 8-oxodG contributes to promotion of lung carcinogenesis initiated by K-ras mutation.
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