Immune regulatory effect of C-type lectin DC-SIGN on colorectal tumors
| Project/Area Number |
20890255
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Ritsumeikan University |
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Principal Investigator |
NONAKA Motohiro Ritsumeikan University, 総合理工学研究機構, 研究員 (70514173)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
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| Keywords | 樹状細胞 / 結腸がん / 免疫制御 / DC-SIGN / MBP / DNA / ファゴサイトーシス / アポトーシス / Jacalin / B細胞 / CD45 |
|---|
| Research Abstract |
We found that C-type lectin DC-SIGN expressed on dendritic cells recognized colorectal tumor-associated Lewis glycans expressed on colorectal carcinoma COLO205 cells, which contributed to tolerogenic immunity for tumor cells. We identified DC-SIGN ligands which were involved in the interaction with DC-SIGN. Moreover, we revealed that mannan binding protein interacted with DNA derived from various orignins in a calcium dependent manner.
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Report
(3 results)
Research Products
(31 results)
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[Journal Article]2009
Author(s)
野中元裕、Ma Bruce Yong、川嵜敏祐
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Journal Title
遺伝子医学MOOK別冊「ますます重要になる細胞周辺環境(細胞ニッチ)」(メディカル ドゥ)
Pages: 257-262
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