| Project/Area Number |
20890263
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kinki University |
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Principal Investigator |
TERAMURA Takeshi Kinki University, 医学部附属病院, 助教 (40460901)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,055,000 (Direct Cost: ¥2,350,000、Indirect Cost: ¥705,000)
Fiscal Year 2009: ¥1,456,000 (Direct Cost: ¥1,120,000、Indirect Cost: ¥336,000)
Fiscal Year 2008: ¥1,599,000 (Direct Cost: ¥1,230,000、Indirect Cost: ¥369,000)
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| Keywords | 再生医療 / 軟骨 / 組織幹細胞 / 分化誘導 / 人工多能性幹細胞 / Synovial tissue / chondrocyte / Stem Cells / regenerative medicine / tissue engineering / Flow cytometry |
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| Research Abstract |
Autologous chondrocyte implantation is an established technique for the repair of degenerated articular cartilage. However, because of limited properties of the chondrocyte such as senescence after in vitro propagation, application of stem cells are aspired and examined for therapies of some diseases actually. This study aimed to establish efficient method for collection and propagation of the stem cells, and to observe the properties of them as the materials for cell therapy for articular cartilage disorders. As one important result of this study, it has been elucidated that reducing serum concentration in the medium and addition of growth factors is significantly improve the stem cell self-renewal. Furthermore, it has also been demonstrated that this technique could be diverted to the efficient method for induction of mesenchymal progenitor cells, which possess a potential to differentiate to the chondrocytes, from induced pluripotent stem cells.
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