The study for the effects of Interluekin-11on cardiac remodeling following myocardial infarction.

• Project/Area Number: 20890267
• Research Category: Grant-in-Aid for Young Scientists (Start-up)
• Allocation Type: Single-year Grants
• Research Field: Medical pharmacy
• Research Institution: Hyogo University of Health Sciences
• Principal Investigator: MAEDA Makiko Hyogo University of Health Sciences, 薬学部, 講師 (70461168)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
• Keywords: 心筋細胞 / サイトカイン / 心筋梗塞 / シグナル / 虚血再灌流

Research Abstract

We investigated the effects of Interluekin-11 (IL-11) on preventing cardiac remodeling following myocardial infarction (MI). As results, IL-11 prevented cardiac remodeling through STAT3 pathway following MI. The results of this study will propose the possibility of IL-11 as a novel cytokine therapy to prevent heart failure.

Research Products

• [Journal Article] IL-11の心血管系における作用. (2010)
  • Author(s): 尾花理徳、前田真貴子、藤尾慈
  • Journal Title: 循環器内科(科学評論社) 67(2) Pages: 156-162
• [Journal Article] Therapeutic activation of STAT3 by Interleukin-11 ameliorates cardiac fibrosis after myocardial infarction. (2010)
  • Author(s): Obana, M., Maeda, M., Takeda, K., Hayama, A., Mohri, T., Yamashita, T., Nakaoka, Y., Komuro, I., Takeda, K., Matsumiya, G., Azuma, J., Fujio, Y.
  • Journal Title: Circulation 121(5) Pages: 684-691
• [Journal Article] Therapeutic activation of STAT3 by Interleukin-11 ameliorates cardiac fibrosis after myocardial infarction. (2010)
  • Author(s): 前田真貴子
  • Journal Title: Circulation 121 Pages: 684-691
  • Peer Reviewed
• [Journal Article] IL-11の心血管系における作用 (2010)
  • Author(s): 前田真貴子
  • Journal Title: 循環器内科 67 Pages: 156-162
  • Peer Reviewed
• [Journal Article] Signals through glycoprotein 130 regulate the endothelial differentiation of cardiac stem cells. (2009)
  • Author(s): Mohri T, Fujio Y, Obana M, Iwakura T, Matsuda K, Maeda M, Azuma J
  • Journal Title: Arterioscler Thromb Vasc Biol. 29(5) Pages: 754-760
• [Journal Article] Signals through glycoprotein 130 regulate the endothelial differentiation of cardiac stem cells. (2009)
  • Author(s): 前田真貴子
  • Journal Title: Arterioscler Thromb Vasc Biol. 29 Pages: 754-760
  • Peer Reviewed
• [Journal Article] Connective tissue growth factor induces cardiac hypertrophy through Akt signaling (2008)
  • Author(s): 前田真貴子
  • Journal Title: Biochem Biophys Res Commun. 370(2) Pages: 274-278
  • Peer Reviewed
• [Journal Article] Atrogin-1 ubiquitin ligase is upregulated by doxorubicin viap3 8-MAP kinase in cardiac myocytes (2008)
  • Author(s): 前田真貴子
  • Journal Title: Cardiovasc Res. 70 Pages: 89-96
  • Peer Reviewed
• [Journal Article] 治療薬の代謝と薬物相互作用 (2008)
  • Author(s): 前田真貴子
  • Journal Title: 新しい診断と治療のABC 13 Pages: 335-343
  • Peer Reviewed
• [Presentation] IL-11は心筋STAT3活性化を介して心筋梗塞後心筋リモデリンダを抑制する (2010)
  • Author(s): 前田真貴子
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 大阪国際会議場(大阪市)
  • Year and Date: 2010-03-17
• [Presentation] IL-11 Ameliorates Cardiac Remodeling after Myocardial infarction viaSTAT3 Pathway Activation in Cardiomyocytes. (2010)
  • Author(s): 前田真貴子
  • Organizer: 第74回日本循環器学会総会・学術集会
  • Place of Presentation: 国立京都国際会館(京都市)
  • Year and Date: 2010-03-05
• [Presentation] IL-11は心筋STAT3活性化を介して心筋梗塞後心筋リモデリングを抑制する. (2010)
  • Author(s): 尾花理徳、藤尾慈、前田真貴子、東純一
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 大阪
• [Presentation] IL-11 Ameliorates Cardiac Remodeling after Myocardial infarction via STAT3 Pathway Activation in Cardiomyocytes. (2010)
  • Author(s): Masanori Obana, Makiko Maeda, Koji Takeda, Goro Matsumiya, Junichi Azuma, Yasushi Fujio
  • Organizer: 第74回日本循環器学会総会・学術集会
  • Place of Presentation: 京都
• [Presentation] 心筋細胞においてIL-10はgp130シグナルによるSTAT3、ERK1/2の活性化を介して誘導される (2009)
  • Author(s): 前田真貴子
  • Organizer: 第82回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-03-17
• [Presentation] 心筋梗塞後心筋における組織幹細胞由来血管内皮細胞の同定. (2009)
  • Author(s): 松田浩一、藤尾慈、毛利友美、尾花理徳、岩倉智彦、山下朋美、端山明子、前田真貴子、東純一
  • Organizer: 第82回日本薬理学会年会
  • Place of Presentation: 横浜