The study for the effects of Interluekin-11on cardiac remodeling following myocardial infarction.
Project/Area Number |
20890267
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Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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Allocation Type | Single-year Grants |
Research Field |
Medical pharmacy
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Research Institution | Hyogo University of Health Sciences |
Principal Investigator |
MAEDA Makiko Hyogo University of Health Sciences, 薬学部, 講師 (70461168)
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Project Period (FY) |
2008 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
|
Keywords | 心筋細胞 / サイトカイン / 心筋梗塞 / シグナル / 虚血再灌流 |
Research Abstract |
We investigated the effects of Interluekin-11 (IL-11) on preventing cardiac remodeling following myocardial infarction (MI). As results, IL-11 prevented cardiac remodeling through STAT3 pathway following MI. The results of this study will propose the possibility of IL-11 as a novel cytokine therapy to prevent heart failure.
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] Therapeutic activation of STAT3 by Interleukin-11 ameliorates cardiac fibrosis after myocardial infarction.2010
Author(s)
Obana, M., Maeda, M., Takeda, K., Hayama, A., Mohri, T., Yamashita, T., Nakaoka, Y., Komuro, I., Takeda, K., Matsumiya, G., Azuma, J., Fujio, Y.
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Journal Title
Circulation 121(5)
Pages: 684-691
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