| Project/Area Number |
20890276
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
|---|
| Research Field |
Biological pharmacy
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|---|
| Research Institution | Sojo University |
|---|
Principal Investigator |
SHUTO Keiko Sojo University, 薬学部, 助手 (70510692)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
|
|---|
| Keywords | 炎症制御 / SIGIRR / LPS / 発現調節 / 自然免疫 |
|---|
| Research Abstract |
SIGIRR/TIR8 has been reported to negatively regulate Toll-like receptor (TLR) signaling, that plays critical role for inflammatory response. However, precise mechanism responsible for the regulation of SIGIRR expression during TLR signaling remains obscure. In this study, we confirmed the regulation of SIGIRR expression by Lipopolysaccharide (LPS), which is well known as a TLR activator. As a result, LPS down regulated SIGIRR expression at transcriptional level. Moreover, p38 MAP kinase downstream of TLR signaling, and transcriptional factor Sp1 were possibly involved in LPS induced SIGIRR down-regulation.
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