Anatomical and functional analysis of medial preoptic area of hypothalamus, the center of mammalian parental behavior
| Project/Area Number |
20890287
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
YOSHIDA Sachine The Institute of Physical and Chemical Research, 黒田研究ユニット, 研究員 (90513458)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 養育行動 / ノックアウトマウス / 視床下部 / 内側視索前野 / Anterior commissural nucleus(ACN) / マウス |
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| Research Abstract |
The brain center of parental behavior is believed to locate in the medial preoptic area (MPOA) of hypothalamus. The present study demonstrated that neurons of anterior commissural nucleus in the dorsolateral MPOA showed the activation during the parental behavior in mice. ACN contained oxytocin (OXT) and thyrotropin-releasing hormone (TRH) immunoreactive neurons. We examined the parental behavior using OXT or TRH knockout mice and double knockout mice. Nest building and pup retrieving behaviors were used as an index for the evaluation of parental behavior. In the preliminary results, however, any significant difference in the parental behavior of the OXT and TRH double knockout mice could not be detected. Further studies with higher sensitivity will be needed in future.
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Report
(3 results)
Research Products
(6 results)
