| Project/Area Number |
20F20109
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| Research Category |
Grant-in-Aid for JSPS Fellows
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| Allocation Type | Single-year Grants |
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| Section | 外国 |
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| Review Section |
Basic Section 59040:Nutrition science and health science-related
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| Research Institution | Kumamoto University |
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Principal Investigator |
小野 悠介 熊本大学, 発生医学研究所, 准教授 (60601119)
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| Co-Investigator(Kenkyū-buntansha) |
ORTUSTE QUIROGA HUASCAR 熊本大学, 発生医学研究所, 外国人特別研究員
ORTUSTE QUIROGA HUASCAR Pedro 熊本大学, 発生医学研究所, 外国人特別研究員
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| Project Period (FY) |
2020-04-24 – 2022-03-31
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| Project Status |
Granted (Fiscal Year 2021)
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| Budget Amount *help |
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 2021: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Outline of Research at the Start |
DUX4 is ectopically expressed in Facioscapulohumeral muscular dystrophy (FSHD) muscles, resulting in a production of potentially toxic proteins. μ-Crystallin (Crym) is known to be abnormally upregulated in the muscles of patients with FSHD. The aim of this study is to characterise the function of Crym in skeletal muscle to develop therapeutic strategies for FSHD disease. We will investigate whether DUX4 toxicity is suppressed by Crym inactivation in muscle using DUX4-expressing Crym KO mice.
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