| Budget Amount *help |
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 2022: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 2021: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2020: ¥800,000 (Direct Cost: ¥800,000)
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| Outline of Research at the Start |
In starved cells, organelles are digested in bulk autophagy to supply nutrients for survival. But the concept of selective autophagy, of individually damaged organelles, gains increasing attention. One of the understudied substrates for selective autophagy is the inner nuclear membrane that faces chromatin and specializes in chromatin organization, cell cycle progression, and transcription. The machinery for autophagic degradation of nuclear membrane, in yeast, has recently been identified. However, in mammals, the substrates and meaning of this process are virtually not known.
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