| Project/Area Number |
20F20779
|
|---|
| Research Category |
Grant-in-Aid for JSPS Fellows
|
| Allocation Type | Single-year Grants |
|---|
| Section | 外国 |
|---|
| Review Section |
Basic Section 90110:Biomedical engineering-related
|
|---|
| Research Institution | Kyoto Institute of Technology |
|---|
Principal Investigator |
PEZZOTTI G. (2020) 京都工芸繊維大学, 材料化学系, 教授 (70262962)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
BOSCHETTO FRANCESCO 京都工芸繊維大学, その他部局等, 外国人特別研究員
|
|---|
| Host Researcher |
PEZZOTTI G. (2021) 京都工芸繊維大学, 材料化学系, 教授 (70262962)
|
|---|
| Foreign Research Fellow |
BOSCHETTO FRANCESCO 京都工芸繊維大学, その他部局等, 外国人特別研究員
|
|---|
| Project Period (FY) |
2020-11-13 – 2022-03-31
|
| Project Status |
Discontinued (Fiscal Year 2021)
|
| Budget Amount *help |
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 2021: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2020: ¥1,000,000 (Direct Cost: ¥1,000,000)
|
|---|
| Keywords | Biomaterials / composite / bone regeneration / 複合材料 / PMMA / クルクミン / 抗菌作用 / 組織再生 / インプラント |
|---|
| Outline of Research at the Start |
整形外科および歯科における生体材料について、次世代の材料の開発が強く求められている。この材料の重要な点が２点ある。１つは、材料表面と細胞の相互作用であり、もうひとつは抗菌性および抗カビ性である。この２点の特性を同時に有する事は非常に難しいとされているが、健康寿命がのびる中で非常に需要の高い課題である。
本研究では、この２点の特性を同時に有する材料の開発を行う事である。
|
| Outline of Annual Research Achievements |
The purpose of this research is to develop next-generation biomaterials in the fields of orthopedics and dentistry by creating a composite and combining natural and artificial materials having bioactivity and antibacterial properties with medical polymers (used in orthopedics and dentistry). In this research the polymer used was PMMA. By itself, it has the drawback of lacking biological activity and antibacterial properties. However, incorporating different concentration of a natural filler, curcumin, these properties could be improved. The choice of curcumin is due to its well-known anti-inflammatory and anti-oxidant properties. Furthermore, some studies indicated how the systemic administration of curcumin significantly improved bone mineral density and trabecular bone architecture in vitro and in vivo tests. Adding different concentration, the properties of the composites have been evaluated usging different techniques and assays. Mechanical and indentation tests showed that PMMA with a high addition of curcumin experienced a clear reduction of the performances compared to the other composites and the untreated PMMA. No relevant variation in surface roughness was detected suggesting that the differences preponderally derived from a chemical interaction between cells and material surface modified with the filler. The most important result was that increasing the concentration of curcumin increased the amount of bone formed on the surface of the composite, suggesting that the rate of formation was dependent on the amount of filler present.
|
| Research Progress Status |
令和3年度が最終年度であるため、記入しない。
|
| Strategy for Future Research Activity |
令和3年度が最終年度であるため、記入しない。
|
