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Somatic symptoms and distortions of emotion and thought: Cognitive neuroscientific approach

Research Project

Project/Area Number 20H00108
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Review Section Medium-sized Section 10:Psychology and related fields
Research InstitutionKeio University

Principal Investigator

Umeda Satoshi  慶應義塾大学, 文学部(三田), 教授 (90317272)

Co-Investigator(Kenkyū-buntansha) 三村 將  慶應義塾大学, 医学部(信濃町), 特任教授 (00190728)
寺澤 悠理  慶應義塾大学, 文学部(日吉), 准教授 (30585790)
Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥45,240,000 (Direct Cost: ¥34,800,000、Indirect Cost: ¥10,440,000)
Fiscal Year 2022: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2021: ¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2020: ¥20,410,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥4,710,000)
Keywords身体症状症 / 自律神経予測処理 / 内受容感覚 / 不安障害 / 感情
Outline of Research at the Start

我が国における不安神経症の患者数は300万人を超えるとも推定されており,これらの背後にあるメカニズムの解明が,喫緊の社会問題であるといえる.なかでも,身体に病気の症状がないにもかかわらず,病気であるという過度な不安を訴える身体症状症(身体表現性障害)は,実際には相当数の症例が存在するが,その発生メカニズムは十分に理解されていない.その主な原因は,これまでの身体症状症の研究において,「心ー脳ー身体」の三方向から統合的に理解しようとする試みが不十分であった点にある.本研究では,身体レベルの自律神経予測処理機能,内受容感覚の正確さ,思考の歪みに着目し,各要素について詳しく調べる課題を用いて検討する.

Outline of Final Research Achievements

Somatic symptoms disorder, in which patients complain of pain and other physical symptoms even though there are no obvious symptoms of physical disease, actually occurs in a considerable number of cases, and certain types of psychotherapy are found to be effective. However, the mechanisms underlying their symptoms are not fully understood. In the present study, we focused on three factors highly involved in the occurrence of symptoms: predictive autonomic nervous functions at the body level, interoceptive accuracy, and distortion of thought, and examined them in detail. The results showed that similar changes in autonomic nervous activities were observed not only in the situation of actual atmospheric pressure fluctuations, but also in the situation of merely predicting them, and that the degrees of those changes were partially associated with interoception, somatic symptom characteristics and the degree of distortion of thought.

Academic Significance and Societal Importance of the Research Achievements

本研究の成果から,身体症状症には,自律神経活動の変動特性が関与し,それが内受容感覚や特有の認知特性とも関連することが明らかになった.身体症状症を一病態とし捉えることは困難であり,身体特性や内受容感覚の観点からいくつかのパターンに分類されることも示された.さらに,一部の症例では,身体の生理機能が予測的な思考のみによって変化しており,身体化の背景にこうした予測的な認知処理も関与していることが示唆された.本研究の成果は,各個人にどのようなセラピ-が有効であるかを事前に予測する観点を提供するものであり,今後,身体症状症の下位分類を実現する上でも重要な示唆を与えるものと期待される.

Report

(5 results)
  • 2023 Final Research Report ( PDF )
  • 2022 Annual Research Report
  • 2021 Annual Research Report
  • 2020 Comments on the Screening Results   Annual Research Report
  • Research Products

    (32 results)

All 2023 2022 2021

All Journal Article (14 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 9 results,  Open Access: 9 results) Presentation (18 results) (of which Int'l Joint Research: 4 results,  Invited: 6 results)

  • [Journal Article] 特集 慢性疼痛 心理的な痛みの機序2023

    • Author(s)
      梅田 聡
    • Journal Title

      BRAIN and NERVE

      Volume: 75 Issue: 3 Pages: 243-252

    • DOI

      10.11477/mf.1416202314

    • ISSN
      1344-8129, 1881-6096
    • Year and Date
      2023-03-01
    • Related Report
      2022 Annual Research Report 2020 Annual Research Report
  • [Journal Article] 感情研究における顔面皮膚血流の有用性と臨床応用2023

    • Author(s)
      石川直樹・梅田 聡
    • Journal Title

      Annual Review 神経 2023

      Volume: 2023 Pages: 282-289

    • Related Report
      2022 Annual Research Report
  • [Journal Article] Modulation of heartbeat-evoked potential and cardiac cycle effect by auditory stimuli2023

    • Author(s)
      Tanaka Yuto、Ito Yuichi、Terasawa Yuri、Umeda Satoshi
    • Journal Title

      Biological Psychology

      Volume: 182 Pages: 108637-108637

    • DOI

      10.1016/j.biopsycho.2023.108637

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 未来に向けられた認知の神経メカニズム2023

    • Author(s)
      梅田 聡
    • Journal Title

      Clinical Neuroscience

      Volume: 41 Pages: 1090-1093

    • Related Report
      2022 Annual Research Report
  • [Journal Article] Effect of subconscious changes in bodily response on thought shifting in people with accurate interoception2023

    • Author(s)
      Sakuragi Mai、Shinagawa Kazushi、Terasawa Yuri、Umeda Satoshi
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1 Pages: 16651-16651

    • DOI

      10.1038/s41598-023-43861-w

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reactivity of observers’ facial skin blood flow depending on others’ facial expressions and blushing2023

    • Author(s)
      Ishikawa Naoki、Asahina Masato、Umeda Satoshi
    • Journal Title

      Frontiers in Psychology

      Volume: 14 Pages: 1259928-1259928

    • DOI

      10.3389/fpsyg.2023.1259928

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Coexistence of thought types as an attentional state during a sustained attention task2023

    • Author(s)
      Shinagawa Kazushi、Itagaki Yu、Umeda Satoshi
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1 Pages: 1581-1581

    • DOI

      10.1038/s41598-023-28690-1

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The effect of cognitive behavioral therapy on future thinking in patients with major depressive disorder: A randomized controlled trial2023

    • Author(s)
      Amano Mizuki、Katayama Nariko、Umeda Satoshi、Terasawa Yuri、Tabuchi Hajime、Kikuchi Toshiaki、Abe Takayuki、Mimura Masaru、Nakagawa Atsuo
    • Journal Title

      Frontiers in Psychiatry

      Volume: 14 Pages: 997154-997154

    • DOI

      10.3389/fpsyt.2023.997154

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cognitive behavioral therapy effects on frontopolar cortex function during future thinking in major depressive disorder: A randomized clinical trial2022

    • Author(s)
      Katayama Nariko、Nakagawa Atsuo、Umeda Satoshi、Terasawa Yuri、Abe Takayuki、Kurata Chika、Sasaki Yohei、Mitsuda Dai、Kikuchi Toshiaki、Tabuchi Hajime、Mimura Masaru
    • Journal Title

      Journal of Affective Disorders

      Volume: 298 Pages: 644-655

    • DOI

      10.1016/j.jad.2021.11.034

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 総説 安静時fMRIにおける動的機能結合の臨床応用2021

    • Author(s)
      品川 和志、寺澤 悠理、梅田 聡
    • Journal Title

      BRAIN and NERVE

      Volume: 73 Issue: 11 Pages: 1267-1273

    • DOI

      10.11477/mf.1416201929

    • ISSN
      1344-8129, 1881-6096
    • Year and Date
      2021-11-01
    • Related Report
      2021 Annual Research Report
  • [Journal Article] 増大特集 脳とからだ Ⅲ.中枢と末梢の相互作用 主観的感情と内受容感覚の神経メカニズム2021

    • Author(s)
      梅田 聡
    • Journal Title

      生体の科学

      Volume: 72 Issue: 5 Pages: 454-456

    • DOI

      10.11477/mf.2425201413

    • ISSN
      0370-9531, 1883-5503
    • Year and Date
      2021-10-15
    • Related Report
      2021 Annual Research Report
  • [Journal Article] Temporal changes in attentional resources consumed by mind-wandering that precede awareness: An ERP study2021

    • Author(s)
      Shinagawa Kazushi、Ito Yuichi、Tsuji Koki、Tanaka Yuto、Odaka Mana、Shibata Midori、Terasawa Yuri、Umeda Satoshi
    • Journal Title

      Neuroimage: Reports

      Volume: 1 Issue: 4 Pages: 100060-100060

    • DOI

      10.1016/j.ynirp.2021.100060

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of interoceptive accuracy in autonomic responses to external stimuli based on cardiac rhythm2021

    • Author(s)
      Tanaka Yuto、Terasawa Yuri、Umeda Satoshi
    • Journal Title

      PLOS ONE

      Volume: 16 Issue: 8 Pages: e0256914-e0256914

    • DOI

      10.1371/journal.pone.0256914

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Paradoxical somatic information processing for interoception and anxiety in alexithymia2021

    • Author(s)
      Terasawa Yuri、Oba Kentaro、Motomura Yuki、Katsunuma Ruri、Murakami Hiroki、Moriguchi Yoshiya
    • Journal Title

      European Journal of Neuroscience

      Volume: 54 Issue: 11 Pages: 8052-8068

    • DOI

      10.1111/ejn.15528

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 嫌悪的状況からの回避可能性の有無が驚愕反射に及ぼす影響2023

    • Author(s)
      前田 真・梅田 聡
    • Organizer
      第41回日本生理心理学会大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 電流刺激に対する顔面および指尖皮膚血流の反応性の検討2023

    • Author(s)
      石川直樹・櫻木麻衣・品川和志・梅田 聡
    • Organizer
      第41回日本生理心理学会大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] The modulation of interoceptive processes during mind-wandering: An ERP/sLORETA study.2023

    • Author(s)
      Shinagawa, K., Terasawa, Y., Tanaka, Y., & Umeda, S.
    • Organizer
      The Annual Meeting of the Organization for Human Brain Mapping 2023.
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Interoception triggers thought about the self.2023

    • Author(s)
      Sakuragi, M., Shinagawa, K., Terasawa, Y., & Umeda, S.
    • Organizer
      The 63rd Annual Meeting of the Society for Psychophysiological Research.
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The modulation of interoceptive processesExploration of improvement in the heartbeat counting task: Evaluation of task performance by simulation.2023

    • Author(s)
      Shinagawa, K., Sakuragi, M., Ishikawa, N., Terasawa, & Umeda, S.
    • Organizer
      The 63rd Annual Meeting of the Society for Psychophysiological Research.
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] International Symposium on Predictive Brain and Cognitive Feelings.2023

    • Author(s)
      Umeda, S.
    • Organizer
      Interoceptive feelings of emotion, memory and pain in clinical populations.
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 不安傾向者における異常な信念更新過程の探索的検討2022

    • Author(s)
      品川和志・石川直樹・平山絢菜・梅田 聡
    • Organizer
      日本認知心理学会第20回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 思考の切り替えにおける内受容感覚の役割2022

    • Author(s)
      櫻木麻衣・梅田 聡
    • Organizer
      日本認知心理学会第20回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 情動と自律神経活動2022

    • Author(s)
      梅田 聡
    • Organizer
      第75回日本自律神経学会総会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 感情を生み出す認知神経メカニズム2022

    • Author(s)
      梅田 聡
    • Organizer
      第21回日本トラウマティック・ストレス学会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 隠れマルコフモデルを用いた課題中の自発思考状態の推定2021

    • Author(s)
      品川和志・板垣 翼・梅田 聡
    • Organizer
      日本心理学会第85回大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 過食性障害傾向者におけるリスクテイキング行動と内受容感覚に関する検討2021

    • Author(s)
      若月 葵・梅田 聡
    • Organizer
      日本心理学会第85回大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 心周期と内受容感覚の関係性: 心拍誘発電位を用いた検討2021

    • Author(s)
      田仲祐登・寺澤悠理・梅田 聡
    • Organizer
      第74回日本自律神経学会総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 他者感情表出の観察時における顔面皮膚血流の反応性2021

    • Author(s)
      石川直樹・朝比奈正人・梅田 聡
    • Organizer
      第74回日本自律神経学会総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 内受容感覚と心拍誘発電位の関係性: 心周期を用いた検討2021

    • Author(s)
      田仲祐登・寺澤悠理・梅田 聡
    • Organizer
      日本発達神経科学会第10回学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 自律神経における予測機能の認知神経メカニズム2021

    • Author(s)
      梅田 聡
    • Organizer
      第74回日本自律神経学会総会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 未来をみつめる認知神経メカニズムの解明2021

    • Author(s)
      梅田 聡
    • Organizer
      日本神経心理学会第45回総会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Emotional disorders associated with anterior insula lesions and autonomic nervous dysfunctions2021

    • Author(s)
      Satoshi Umeda
    • Organizer
      The 44th Annual Meeting of the Japan Neuroscience Society
    • Related Report
      2021 Annual Research Report
    • Invited

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Published: 2020-04-28   Modified: 2025-01-30  

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