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Fundamental study for medical and industrial applications of vesicles containing microbubbles

Research Project

Project/Area Number 20H00222
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Review Section Medium-sized Section 19:Fluid engineering, thermal engineering, and related fields
Research InstitutionThe University of Tokyo

Principal Investigator

Takagi Shu  東京大学, 大学院工学系研究科(工学部), 教授 (30272371)

Co-Investigator(Kenkyū-buntansha) 一柳 満久  上智大学, 理工学部, 教授 (00584252)
杵淵 郁也  東京大学, 大学院工学系研究科(工学部), 准教授 (30456165)
杉山 和靖  大阪大学, 大学院基礎工学研究科, 教授 (50466786)
田川 義之  東京農工大学, 工学(系)研究科(研究院), 教授 (70700011)
Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥45,370,000 (Direct Cost: ¥34,900,000、Indirect Cost: ¥10,470,000)
Fiscal Year 2022: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Fiscal Year 2021: ¥20,280,000 (Direct Cost: ¥15,600,000、Indirect Cost: ¥4,680,000)
Fiscal Year 2020: ¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Keywordsマイクロバブル / ベシクル / マイクロチャネル / 油水界面通過法 / 超音波 / ドラッグデリバリーシステム / 気泡クラスター / 液滴 / ビヤクネス力 / 血管造影剤
Outline of Research at the Start

本研究では,直径1~5ミクロンのマイクロバブルを直径5~100ミクロンサイズのベシクルに内包させる技術を確立する.そのために,精緻な数値計算,理論との統合的解析により,合理的にマイクロバブル内包ベシクルを生成する手法について検討する.さらに,ベシクル内部に種々の物質を内包させることにより,薬剤搬送システム(DDS)やマイクロ化学反応器へ利用していくための基盤技術の構築を行う.特に集束超音波を用いたシステムとの統合により,医療・産業応用に向けた,マイクロバブル内包ベシクルの生成,制御,破壊システムの構築を目指す.

Outline of Final Research Achievements

In this study, we successfully achieved the mass production of microbubble-encapsulated water droplets with a diameter of less than 5 microns using a flow-focusing type microchannel. Furthermore, we succeeded in generating microbubble-encapsulated vesicles with diameters below 5 microns by employing the oil-water interfacial passage method on the generated droplets. Additionally, as a selective manipulation technique for the microbubble-encapsulated vesicles, we explored the use of acoustic radiation force through ultrasound irradiation, and successfully demonstrated the movement of the vesicles under ultrasound exposure using an ultrasound transducer. These techniques form the fundamental basis for manipulating vesicles using ultrasound irradiation, particularly in scenarios such as extracorporeal applications and remote fields.

Academic Significance and Societal Importance of the Research Achievements

直径5ミクロン以下のマイクロバブルを内包ベシクルを生成し,遠方から照射した超音波により目的部位に移動させ,さらに膜の破壊を行えるようになると,ドラッグデリバリーシステム(DDS)への利用が可能となる.従来型のDDSに比べカプセル(ベシクル),サイズが各段に大きいため大量の薬剤の封入が可能となる.超音波によるベシクルの輸送・破壊技術は,医療応用だけでなく,カプセルの融合による化学反応の促進など様々な技術への応用が考えられる.

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Comments on the Screening Results   Annual Research Report
  • Research Products

    (15 results)

All 2023 2022 2021

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (13 results) (of which Int'l Joint Research: 8 results,  Invited: 2 results)

  • [Journal Article] Numerical Study of Particle Margination in a Square Channel Flow with Red Blood Cells2022

    • Author(s)
      Oh Dongig、Ii Satoshi、Takagi Shu
    • Journal Title

      Fluids

      Volume: 7 Issue: 3 Pages: 96-96

    • DOI

      10.3390/fluids7030096

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Numerical Study of Particle Margination in a Square Channel Flow with Red Blood Cells2022

    • Author(s)
      Dongig Oh, Satoshi Ii, Shu Takagi
    • Journal Title

      fluids

      Volume: 7 Pages: 96-115

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Dynamics of a Rising Bubble and Bubble Cluster2023

    • Author(s)
      Shu Takagi
    • Organizer
      The 11th International Conference on Multiphase Flow
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Characterization of dynamic features of bubbly flow rising in a slightly inclined vertical pipe: A three-dimensional numerical study2023

    • Author(s)
      Yijie Liu, Shu Takagi, Kazuyasu Sugiyama
    • Organizer
      The 11th International Conference on Multiphase Flow
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Formation of Microbubble-encapsulated Vesicle by Flow-focusing and Inverted Emulsion2023

    • Author(s)
      Ryuki Kakukawa, Hiroko Shiozaki, Ryota Kiyozumi, Mitsuhisa Ichiyanagi, Shu Takagi
    • Organizer
      The 11th International Conference on Multiphase Flow
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Generation of Microbubble Encapsulated Vesicles and the Manipulations using Ultrasound Field2022

    • Author(s)
      Shu Takagi, R. Kakukawa, R. Kiyozumi, B. Chen and M. Ichiyanagi
    • Organizer
      European-American-Japanese Two-Phase Flow Group Meeting
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Numerical study of particle margination in a square channel flow with red blood cells2022

    • Author(s)
      Shu Takagi, Dongig Oh, Satoshi Ii
    • Organizer
      9th World Congress of Biomechanics
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Ultrasound Measurement for Prediction of Gas-Liquid Two-Phase Flow Patterns2022

    • Author(s)
      Maehara, K., Obana, R., Watanabe, I., Shimizu, K., Yoshimoto, Y., & Takagi, S
    • Organizer
      75th Annual Meeting, APS-DFD
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 脳内におけるリンパの流れのモデリング2022

    • Author(s)
      BERMUDEZ Juan Sebastian,高木周
    • Organizer
      日本流体力学会年会2022
    • Related Report
      2022 Annual Research Report
  • [Presentation] フローフォーカス型流路と油水界面通過法によるマイクロバブル内包ベシクルの生成2022

    • Author(s)
      角川龍輝,塩崎寛子,一柳満久,高木周
    • Organizer
      第66回理論応用力学講演会
    • Related Report
      2022 Annual Research Report
  • [Presentation] ON THE BEHAVIOR OF MICROBUBBLE CLUSTERS IN ULTRASOUND FIELD2021

    • Author(s)
      Hironobu Matsuzaki, Yunqiao Liu, Kazuyasu Sugiyama and Shu Takagi
    • Organizer
      25th International Congress of Theoretical and Applied Mechanics
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of micro-vesicles generation method using flow-focusing device2021

    • Author(s)
      Hiroko Shiozaki, Ryuki Kakukawa, Ikuya Kinefuchi, Mitsuhisa Ichiyanagi, Yoshiyuki Tagawa, Shu Takagi
    • Organizer
      74th Annual Meeting, APS-DFD
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ランジュバン方程式による血小板のマージネーションモデルの構築2021

    • Author(s)
      細井隼,呉東益,杵淵郁也,高木周
    • Organizer
      第35回数値流体力学シンポジウム
    • Related Report
      2021 Annual Research Report
  • [Presentation] ON THE BEHAVIOR OF MICROBUBBLE CLUSTERS IN ULTRASOUND FIELD2021

    • Author(s)
      Hironobu Matsuzaki, Yunqiao Liu, Kazuyasu Sugiyama, Shu Takagi,
    • Organizer
      The 25th International Congress of Theoretical and Applied Mechanics
    • Related Report
      2020 Annual Research Report
  • [Presentation] Development of microbubble-encapsulated-vesicles generation method using flow-focusing device2021

    • Author(s)
      Hiroko Shiozaki, Ikuya Kinefuchi, Mitsuhisa Ichiyanagi, Yoshiaki Tagawa, Shu Takagi
    • Organizer
      Annual Meeting of DFD, American Physical Society
    • Related Report
      2020 Annual Research Report

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Published: 2020-04-28   Modified: 2024-01-30  

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