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Intelligent directed evolution: technology development and application to yeast

Research Project

Project/Area Number 20H00317
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Review Section Medium-sized Section 27:Chemical engineering and related fields
Research InstitutionThe University of Tokyo

Principal Investigator

Goda Keisuke  東京大学, 大学院理学系研究科(理学部), 教授 (70518696)

Co-Investigator(Kenkyū-buntansha) 上村 想太郎  東京大学, 大学院理学系研究科(理学部), 教授 (00447442)
大矢 禎一  東京大学, 大学院新領域創成科学研究科, 教授 (20183767)
Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥45,630,000 (Direct Cost: ¥35,100,000、Indirect Cost: ¥10,530,000)
Fiscal Year 2022: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
Fiscal Year 2021: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000)
Fiscal Year 2020: ¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Keywords指向性進化法 / 細胞分取 / 酵母 / 発酵 / 遺伝学 / イメージング / 微生物
Outline of Research at the Start

本研究では、2018年に研究代表者らが多分野の最先端技術を結集させて開発した独自技術であるインテリジェント画像活性細胞選抜法を基盤に、従来手法よりも1000倍以上高速で深層学習を用いたリアルタイム多変量分析による指向性進化法「インテリジェント指向性進化法」を開発し、それを用いた特定の形態を持つスーパー酵母の創出を目的とする。すなわち、酵母に対して形態的特徴に着目した品種改良を行うという画期的なアイディアで、これまで得られなかったような高効率な発酵特性を持つ酵母などの創出により醸造・発酵業界に貢献することを目指す。

Outline of Final Research Achievements

This research is based on a unique technology developed by the lead principal investigator’s group in 2018, termed as Intelligent Image-Activated Cell Sorting (iIACS). The study aims to develop an efficient “Intelligent Directed Evolution Method”, with the goal of creating super yeast showing specific morphological characteristics. In this research, we have performed technology improvements of the cell sorting method, separation and sequencing of actual yeast cells, and practical applications such as beer brewing using separated cells. Through these efforts, we were able to build foundational technology for the directed evolution method of yeast using iIACS, and conduct technical verifications in an application aligned with the possible future social implementation of the technique. These results allowed us to demonstrate both the efficacy and the extensibility of the Intelligent Directed Evolution Method in the creation of super yeast.

Academic Significance and Societal Importance of the Research Achievements

本研究では、酵母細胞の形態解析速度を加速させ、醸造・発酵に有効な優れた酵母を創出することを可能とする、新しい多変量分析による指向性進化法を開発した。本研究で確立した手法を用いることで、指向性進化のみならず、酵母を用いた生理学的な研究への展開が期待される。iIACSの技術革新による細胞選抜速度と精度の改善とともに、分取した酵母細胞によるビール醸造テストも行った。これにより、本技術を用いての醸造・発酵業界への貢献の見通しを示した。酵母の持つ幅広い物質生産性能力を鑑みると、本研究の成果は、オイル生産や創薬へも繋がり、SDGsや人類の健康に資するスーパー酵母の作出を可能にするものであると期待できる。

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Comments on the Screening Results   Annual Research Report
  • Research Products

    (64 results)

All 2023 2022 2021 2020 Other

All Int'l Joint Research (8 results) Journal Article (14 results) (of which Int'l Joint Research: 14 results,  Peer Reviewed: 13 results,  Open Access: 8 results) Presentation (34 results) (of which Int'l Joint Research: 16 results) Book (2 results) Remarks (3 results) Patent(Industrial Property Rights) (3 results)

  • [Int'l Joint Research] University of Virginia/Carnegie Institution of Science/Stanford University(米国)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] Nanyang Technological University(シンガポール)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] Max Planck Institute(ドイツ)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] Wuhan University/HKUST(中国)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] University of Virginia/Carnegie Institution of Science/Stanford University(米国)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] Wuhan University(中国)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] University of Virginia/UCLA/Stanford University(米国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] Wuhan University(中国)

    • Related Report
      2020 Annual Research Report
  • [Journal Article] Studying the efficacy of antiplatelet drugs on atherosclerosis by optofluidic imaging on a chip2023

    • Author(s)
      Deng Yunjie、Tay Hui Min、Zhou Yuqi、Fei Xueer、Tang Xuke、Nishikawa Masako、Yatomi Yutaka、Hou Han Wei、Xiao Ting-Hui、Goda Keisuke
    • Journal Title

      Lab on a Chip

      Volume: 23 Issue: 3 Pages: 410-420

    • DOI

      10.1039/d2lc00895e

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Virtual-freezing fluorescence imaging flow cytometry with 5-aminolevulinic acid stimulation and antibody labeling for detecting all forms of circulating tumor cells2023

    • Author(s)
      Matsumura Hiroki、Shen Larina Tzu-Wei、Isozaki Akihiro、Mikami Hideharu、Yuan Dan、Miura Taichi、Kondo Yuto、Mori Tomoko、Kusumoto Yoshika、Nishikawa Masako、Yasumoto Atsushi、Ueda Aya、Bando Hiroko、Hara Hisato、Liu Yuhong、Deng Yunjie、Sonoshita Masahiro、Yatomi Yutaka、Goda Keisuke、Matsusaka Satoshi
    • Journal Title

      Lab on a Chip

      Volume: 23 Issue: 6 Pages: 1561-1575

    • DOI

      10.1039/d2lc00856d

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Real‐time intelligent classification of COVID‐19 and thrombosis via massive image‐based analysis of platelet aggregates2023

    • Author(s)
      Zhang Chenqi、Herbig Maik、Zhou Yuqi、Nishikawa Masako、Shifat‐E‐Rabbi Mohammad、Kanno Hiroshi、Yang Ruoxi、Ibayashi Yuma、Xiao Ting‐Hui、Rohde Gustavo K.、Sato Masataka、Kodera Satoshi、Daimon Masao、Yatomi Yutaka、Goda Keisuke
    • Journal Title

      Cytometry Part A

      Volume: - Issue: 6 Pages: 1-8

    • DOI

      10.1002/cyto.a.24721

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Understanding stenosis-induced platelet aggregation on a chip by high-speed optical imaging2022

    • Author(s)
      Deng Yunjie、Duque Jaime Alvarez、Su Chengxun、Zhou Yuqi、Nishikawa Masako、Xiao Ting-Hui、Yatomi Yutaka、Hou Han Wei、Goda Keisuke
    • Journal Title

      Sensors and Actuators B: Chemical

      Volume: 356 Pages: 131318-131318

    • DOI

      10.1016/j.snb.2021.131318

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Intelligent image‐activated sorting of Chlamydomonas reinhardtii by mitochondrial localization2022

    • Author(s)
      Harmon Jeffrey、Findinier Justin、Ishii Natsumi Tiffany、Herbig Maik、Isozaki Akihiro、Grossman Arthur、Goda Keisuke
    • Journal Title

      Cytometry Part A

      Volume: 101 Issue: 12 Pages: 1027-1034

    • DOI

      10.1002/cyto.a.24661

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Best practices for reporting throughput in biomedical research2022

    • Author(s)
      Herbig Maik、Isozaki Akihiro、Di Carlo Dino、Guck Jochen、Nitta Nao、Damoiseaux Robert、Kamikawaji Shogo、Suyama Eigo、Shintaku Hirofumi、Wu Angela Ruohao、Nikaido Itoshi、Goda Keisuke
    • Journal Title

      Nature Methods

      Volume: 19 Issue: 6 Pages: 633-634

    • DOI

      10.1038/s41592-022-01483-6

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Intelligent sort‐timing prediction for image‐activated cell sorting2022

    • Author(s)
      Zhao Yaqi、Isozaki Akihiro、Herbig Maik、Hayashi Mika、Hiramatsu Kotaro、Yamazaki Sota、Kondo Naoko、Ohnuki Shinsuke、Ohya Yoshikazu、Nitta Nao、Goda Keisuke
    • Journal Title

      Cytometry Part A

      Volume: 103 Issue: 1 Pages: 88-97

    • DOI

      10.1002/cyto.a.24664

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Long‐term effects of Pfizer‐BioNTech COVID‐19 vaccinations on platelets2022

    • Author(s)
      Zhou Yuqi、Nishikawa Masako、Kanno Hiroshi、Yang Ruoxi、Ibayashi Yuma、Xiao Ting‐Hui、Peterson Walker、Herbig Maik、Nitta Nao、Miyata Shigeki、Kanthi Yogendra、Rohde Gustavo K.、Moriya Kyoji、Yatomi Yutaka、Goda Keisuke
    • Journal Title

      Cytometry Part A

      Volume: 103 Issue: 2 Pages: 162-167

    • DOI

      10.1002/cyto.a.24677

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Deep imaging flow cytometry.2022

    • Author(s)
      Huang K, Matsumura H, Zhao Y, Herbig M, Yuan D, Mineharu Y, Harmon J, Findinier J, Yamagishi M, Ohnuki S, Nitta N, Grossman AR, Ohya Y, Mikami H, Isozaki A, Goda K.
    • Journal Title

      Lab Chip.

      Volume: 22 Issue: 5 Pages: 876-889

    • DOI

      10.1039/d1lc01043c

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Analyzing circulating platelet aggregates in patients with COVID-19 by massive image-based single-cell profiling2022

    • Author(s)
      H. Kanno、M. Nishikawa、Y. Zhou、T. Xiao、T. Suzuki、Y. Ibayashi、J. Harmon、S. Takizawa、K. Hiramatsu、N. Nitta、R. Kameyama、W. Peterson、J. Takiguchi、M. Shifat-E-Rabbi、Y. Zhuang、X. Yin、A. H. M. Rubaiyat、Y. Deng、H. Zhang、S. Miyata、G. K. Rohde、W. Iwasaki、Y. Yatomi、K. Goda
    • Journal Title

      化学とマイクロ・ナノシステム学会誌

      Volume: 21 Pages: 1-11

    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Journal Article] Morphological Indicator for Directed Evolution of Euglena gracilis with a High Heavy Metal Removal Efficiency2021

    • Author(s)
      Xu Muzhen、Harmon Jeffrey、Yuan Dan、Yan Sheng、Lei Cheng、Hiramatsu Kotaro、Zhou Yuqi、Loo Mun Hong、Hasunuma Tomohisa、Isozaki Akihiro、Goda Keisuke
    • Journal Title

      Environmental Science & Technology

      Volume: ‐ Issue: 12 Pages: 7880-7889

    • DOI

      10.1021/acs.est.0c05278

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Intelligent Platelet Morphometry2021

    • Author(s)
      Zhou Yuqi、Isozaki Akihiro、Yasumoto Atsushi、Xiao Ting-Hui、Yatomi Yutaka、Lei Cheng、Goda Keisuke
    • Journal Title

      Trends in Biotechnology

      Volume: 39 Issue: 10 Pages: 978-989

    • DOI

      10.1016/j.tibtech.2020.12.012

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Massive image-based single-cell profiling reveals high levels of circulating platelet aggregates in patients with COVID-192021

    • Author(s)
      Nishikawa Masako、Kanno Hiroshi、Zhou Yuqi et al.
    • Journal Title

      Nature Communications

      Volume: 12 Issue: 1 Pages: 7135-7135

    • DOI

      10.1038/s41467-021-27378-2

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] AI on a chip2020

    • Author(s)
      Isozaki Akihiro、Harmon Jeffrey、Zhou Yuqi、Li Shuai、Nakagawa Yuta、Hayashi Mika、Mikami Hideharu、Lei Cheng、Goda Keisuke
    • Journal Title

      Lab on a Chip

      Volume: 20 Issue: 17 Pages: 3074-3090

    • DOI

      10.1039/d0lc00521e

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Deciphering the efficacy of antiplatelet drugs under vascular stenosis by high-speed on-chip optofluidic imaging2023

    • Author(s)
      Y. Deng, H. M. Tay, Y. Zhou, X. Fei, M. Nishikawa, T.-H. Xiao, Y. Yatomi, H. W. Hou, K. Goda
    • Organizer
      SPIE Photonics West 2023
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Uncovering the long-term effects of mRNA COVID-19 vaccinations on platelets by high-speed optical imaging on a chip2023

    • Author(s)
      Y. Zhou, M. Nishikawa, H. Kanno, R. Yang, Y. Ibayashi, T.-H. Xiao, W. Peterson, M. Herbig, N. Nitta, S. Miyata, Y. Kanthi, G. K. Rohde, K. Moriya, Y. Yatomi, K. Goda
    • Organizer
      SPIE Photonics West 2023
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 血小板凝集塊の無標識画像ヒックテータによる COVID-19 と血栓症のリアルタイム AI 分類2023

    • Author(s)
      張 晨祺, Herbig Maik, 周 雨奇, 西川 真子, Shifat-E-Rabbi Mohammad, 菅野 寛志 , 楊 若曦 , 伊林 侑真 , 肖 廷輝 , Rohde Gustavo, 佐藤 将敬 , 小寺 聡, 大門 雅夫, 矢冨 裕, 合田 圭介
    • Organizer
      第70回 応用物理学会 春季学術講演会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Intelligent image-activated cell sorting based on complex intracellular morphology2022

    • Author(s)
      Jeffrey Harmon, Justin Findinier, Natsumi Tiffany Ishii, Maik Herbig, Akihiro Isozaki, Arthur R. Grossman, and Keisuke Goda
    • Organizer
      化学とマイクロ・ナノシステム学会第45回研究会
    • Related Report
      2022 Annual Research Report
  • [Presentation] “高速イメージングフローサイトメトリーによるユーグレナ細胞の形態と重金属の除去効率の関係性解明2022

    • Author(s)
      小林 飛翔, Xu Muzhen, Jeffery Harmon, シャクマトフ 理人, 磯崎 瑛宏, 合田 圭介
    • Organizer
      化学とマイクロ・ナノシステム学会第45回研究会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Machine learning-based sort-timing prediction for image-activated cell sorting2022

    • Author(s)
      Yaqi Zhao, Akihiro Isozaki, Maik Herbig, Mika Hayashi, Kotaro Hiramatsu, Sota Yamazaki, Naoko Kondo, Shinsuke Ohnuki, Yoshikazu Ohya, Nao Nitta, and Keisuke Goda
    • Organizer
      化学とマイクロ・ナノシステム学会第45回研究会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Detection and characterization of circulating tumor cell clusters by high-throughput optomechanical imaging flow cytometry2022

    • Author(s)
      Hiroki Matsumura, Larina Shen, Akihiro Isozaki, Hideharu Mikami, Dan Yuan, Maik Herbig, Yuto Kondo, Tomoko Mori, Yoshika Kusumoto, Masako Nishikawa, Yutaka Yatomi, Satoshi Matsusaka, Keisuke Goda
    • Organizer
      CYTO 2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A standardized metric for throughput for cytometry2022

    • Author(s)
      Maik Herbig, Akihiro Isozaki, Dino Di Carlo, Jochen Guck, Nao Nitta, Robert Damoiseaux, Shogo Kamikawaji, Eigo Suyama, Hirofumi Shintaku, Angela Ruohao Wu, Itoshi Nikaido, and Keisuke Goda
    • Organizer
      CYTO 2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] High-throughput image-activated cell sorting by mitochondrial relocation2022

    • Author(s)
      Maik Herbig, Jeffrey Harmon, Justin Findinier, Natsumi Tiffany Ishii, Akihiro Isozaki, Arthur R. Grossman, and Keisuke Goda
    • Organizer
      CYTO 2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Resolution-enhanced imaging flow cytometry by deep learning2022

    • Author(s)
      Maik Herbig, Kangrui Huang, Hiroki Matsumura, Yaqi Zhao, Dan Yuan, Yohei Mineharu, Jeffrey Harmon, Justin Findinier, Mai Yamagishi, Shinsuke Ohnuki, Nao Nitta, Arthur R. Grossman, Yoshikazu Ohya, Hideharu Mikami, Akihiro Isozaki, and Keisuke Goda
    • Organizer
      CYTO 2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Uncovering the pathogenesis and treatment of atherosclerosis by high-throughput microscopy2022

    • Author(s)
      Y. Deng, J. Duque, C. Su, Y. Zhou, M. Nishikawa, T. Xiao, Y. Yatomi, H. Hou, K. Goda
    • Organizer
      CYTO 2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Uncovering the pathogenesis of microvascular thrombosis in COVID-19 via high-throughput microscopy on a chip2022

    • Author(s)
      Y. Zhou, M. Nishikawa, H. Kanno, T.-H. Xiao, C. Zhang, M. Herbig, Y. Ibayashi, N. Nitta, S. Miyata, G. K. Rohde, Y. Yatomi, K. Goda
    • Organizer
      CYTO 2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] COVID-19における血小板凝集塊の大規模イメージング解析2022

    • Author(s)
      西川真子, 菅野寛志, Yuqi Zhou, Ting-Hui Xiao, 矢冨裕, 合田圭介
    • Organizer
      第44回日本血栓止血学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] オンチップ血管狭窄と高速イメージングを用いた血小板凝集の統計解析2022

    • Author(s)
      周 雨奇, 鄧 云杰, ハイメ・アルバレス・ドゥケ, 蘇 成迅, 西川 真子, 肖 廷輝, 矢冨 裕, 侯 翰偉, 合田 圭介
    • Organizer
      第44回日本血栓止血学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] mRNA COVID-19ワクチン接種の血小板への長期的影響2022

    • Author(s)
      周 雨奇, 西川 真子, 菅野 寛志, Ruoxi Yang, 肖 廷輝, 矢冨 裕, 合田 圭介
    • Organizer
      第44回日本血栓止血学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] イメージングフローサイトメトリーによる免疫細胞の受容体局在とサイトカイン産生の関連性探索2022

    • Author(s)
      磯崎 瑛宏, Natsumi Tiffany Ishii, 北 一真, 岡 祐馬, 山岸 舞, Yaqi Zhao, 柳田 匡俊, 合田 圭介
    • Organizer
      化学とマイクロ・ナノシステム学会第46回研究会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 血中循環腫瘍細胞の分取に向けた粘弾性流体制御によるオンチップセルソーター2022

    • Author(s)
      長坂 柚葵, 松村 洋貴, 中川 悠太, 磯﨑 瑛宏, 合田 圭介
    • Organizer
      化学とマイクロ・ナノシステム学会第46回研究会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Feasibility study of the method for obtaining fluorogenic RNA aptamers using water-in-oil microdroplets2022

    • Author(s)
      Keisuke Ito, Ryo Iizuka, Sotaro Uemura
    • Organizer
      第60回日本生物物理学会年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Development of a single-particle inclusions detection method by solid-state nanopore for miRNA in single exosome detection2022

    • Author(s)
      Takumi Uchida, Hirohito Yamazaki, Ryo Iizuka, Sotaro Uemura
    • Organizer
      第60回日本生物物理学会年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Investigation of the effect of spherical (three-dimensional) confinement on the higher order structure of 12-mer nucleosome arrays2022

    • Author(s)
      Masahiro Okabe, Ryo Iizuka, Munetaka Akatsu, Kenta Echigoya, Tomoya Kujirai, Hitoshi Kurumizaka, Sotaro Uemura
    • Organizer
      第60回日本生物物理学会年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] A study on the structural dynamics of the nucleosome containing H2A.B using solid-state nanopores2022

    • Author(s)
      Hikaru Nozawa, Hirohito Yamazaki, Ryo Iizuka, Rina Hirano, Tomoya Kujirai, Hitoshi Kurumizaka, Sotaro Uemura
    • Organizer
      第60回日本生物物理学会年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] ナノポア計測によるCALHM2チャネルダイナミクスの解明2022

    • Author(s)
      中村宗太郎、山崎洋人、志甫谷渉、濡木理、上村想太郎
    • Organizer
      第60回日本生物物理学会年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] ショウジョウバエアルゴノート 2 の N 末端領域はアミロイド様凝集体を形成する(N-terminal region of Drosophila Argonaute2 can form amyloid-like aggregates)2022

    • Author(s)
      成田 晴香、島 知弘、飯塚 怜、塩見 美喜子、上村 想太郎
    • Organizer
      第21回東京大学生命科学シンポジウム
    • Related Report
      2022 Annual Research Report
  • [Presentation] Studying vascular stenosis by high-throughput optical microscopy on a chip2022

    • Author(s)
      Y. Deng, J. A. Duque, C. Su, Y. Zhou, M. Nishikawa, T. Xiao, Y. Yatomi, H. W. Hou, K. Goda
    • Organizer
      SPIE Photonics West 2022
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] AI on a chip for identifying microalgal cells with high heavy metal removal efficiency2021

    • Author(s)
      Muzhen Xu, Jeffrey Harmon, Tomohisa Hasunuma, Akihiro Isozaki, and Keisuke Goda
    • Organizer
      The 21st International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers2021)
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] High-throughput intelligent image-activated sorting of receptor-localizing T cells2021

    • Author(s)
      Natsumi Tiffany Ishii, Tsubasa Wakamiya, Taketo Araki, Mika Hayashi, Hiroki Matsumura, Kazuma Kita, Yuma Oka, Masatoshi Yanagida, Akihiro Isozaki, and Keisuke Goda
    • Organizer
      The 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS2021)
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Image-activated sorting of genetically perturbed yeast towards image-based pooled screens2021

    • Author(s)
      Mika Hayashi, Natsumi Tiffany Ishii, Jeffrey Harmon, Taketo Araki, Shinsuke Ohnuki, Naoko Kondo, Akihiro Isozaki, Yoshikazu Ohya, and Keisuke Goda
    • Organizer
      The 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS2021)
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] High speed FLIM, high-throughput FLIM flow cytometry, and beyond2021

    • Author(s)
      Hiroshi Kanno, Hideharu Mikami, Hiramatsu Kotaro, and Keisuke Goda
    • Organizer
      Pacifichem 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Deep learning based classification of Chlamydomonas reinhardtii displaying mitochondrial repositioning using an imaging flow cytometer2021

    • Author(s)
      Jeffrey Harmon, Justin Findinier, Akihiro Isozaki, Arthur Grossman, and Keisuke Goda
    • Organizer
      The international Chemical Congress of Pacific Basin Societies 2021 (Pacifichem 2021)
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] High-throughput on-chip imaging of diverse cancer cells in blood2021

    • Author(s)
      Hiroki Matsumura, Larina Tzu-Wei Shen, Hideharu Mikami, Akihiro Isozaki, Dan Yuan, Taichi Miura, Yoshika Kusumoto, Masako Nishikawa, Atsushi Yasumoto, Takeshi Yamada, Aya Ueda, Hiroko Bando, Hisato Hara, Yutaka Yatomi, Satoshi Matsusaka, and Keisuke Goda
    • Organizer
      The international Chemical Congress of Pacific Basin Societies 2021 (Pacifichem 2021)
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mitochondrial Translocation of Telomerase Reverse Transcriptase Changes Cell Death Process2021

    • Author(s)
      Hiroshi Ebata, Tomohiro Shima, Yoshitaka Shirasaki, Sotaro Uemura
    • Organizer
      Cell Bio Virtual 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] テロメラーゼ逆転写酵素TERTのミトコンドリア輸送の細胞死制御2021

    • Author(s)
      江端拓志, 島知弘, 白崎善隆, 上村想太郎
    • Organizer
      第44回 日本分子生物学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] A cellular morphological indicator toward directed evolution of microalgae for highly efficient wastewater treatment2020

    • Author(s)
      M. Xu, D. Yuan, S. Yan, C. Lei, K. Hiramatsu, J. Harmon, Y. Zhou, M. H. Loo, T. Hasunuma, A. Isozaki, and K. Goda
    • Organizer
      化学とマイクロ・ナノシステム学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 出芽酵母の大規模な遺伝子解析のための高スループット細胞形態分取法2020

    • Author(s)
      H. Matsumura, A. Isozaki, Y. Zhao, K. Huang, T. Wakamiya, D. Yuan, H. Mikami, S. Ohnuki, S. Uemura, Y. Ohya, and K. Goda
    • Organizer
      化学とマイクロ・ナノシステム学会
    • Related Report
      2020 Annual Research Report
  • [Book] 生体分子環境の化学2023

    • Author(s)
      日本化学会
    • Total Pages
      208
    • Publisher
      化学同人
    • ISBN
      9784759814057
    • Related Report
      2022 Annual Research Report
  • [Book] 先端の分析法 第2版2022

    • Author(s)
      澤田 嗣郎、小澤 岳昌、北森 武彦、中村 洋(東京理科大学名誉教授)、藤浪 眞紀、宮村 一夫、石丸 洋一郎、浦野 泰照、加地 範匡、坂 真智子、鈴木 茂、瀬藤 光利、宗林 由樹、馬場 嘉信、船津 公人、本田 暁紀、末永 智一、宮野 博、本山 晃
    • Total Pages
      1072
    • Publisher
      エヌ・ティー・エス
    • ISBN
      9784860437374
    • Related Report
      2021 Annual Research Report
  • [Remarks] Serendipity Lab

    • URL

      http://www.serendipitylab.org/

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report 2020 Annual Research Report
  • [Remarks] Goda Lab

    • URL

      https://www.chem.s.u-tokyo.ac.jp/users/struct/index.html

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
  • [Remarks] Goda Lab

    • URL

      http://www.chem.s.u-tokyo.ac.jp/users/struct/index.html

    • Related Report
      2020 Annual Research Report
  • [Patent(Industrial Property Rights)] ゲノム改変微生物株2021

    • Inventor(s)
      大矢禎一、茶谷朋哉、赤尾健、五島徹也
    • Industrial Property Rights Holder
      国立大学法人 東京大学、独立行政法人酒類総合研究所
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2021-082633
    • Filing Date
      2021
    • Related Report
      2021 Annual Research Report
  • [Patent(Industrial Property Rights)] 酵母の産業適格性予測システム及び方法2021

    • Inventor(s)
      大矢禎一、大貫慎輔、呉俊元、増尾直久、岩切亮
    • Industrial Property Rights Holder
      国立大学法人 東京大学、三菱商事ライフサイエンス株式会社
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2021-107905
    • Filing Date
      2021
    • Related Report
      2021 Annual Research Report
  • [Patent(Industrial Property Rights)] 8-8ジフェルラ酸誘導体2021

    • Inventor(s)
      大矢禎一、一刀かおり、小川樹、他4名
    • Industrial Property Rights Holder
      国立大学法人 東京大学、他1機関
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2021-136651
    • Filing Date
      2021
    • Related Report
      2021 Annual Research Report

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Published: 2020-04-28   Modified: 2024-01-30  

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