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Structure-function studies of enzymes involved in natural product biosynthesis for drug discovery

Research Project

Project/Area Number 20H00490
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Review Section Medium-sized Section 47:Pharmaceutical sciences and related fields
Research InstitutionThe University of Tokyo

Principal Investigator

ABE Ikuro  東京大学, 大学院薬学系研究科(薬学部), 教授 (40305496)

Co-Investigator(Kenkyū-buntansha) 淡川 孝義  東京大学, 大学院薬学系研究科(薬学部), 准教授 (80609834)
森 貴裕  東京大学, 大学院薬学系研究科(薬学部), 助教 (60734564)
牛丸 理一郎  東京大学, 大学院薬学系研究科(薬学部), 助教 (10873648)
Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥44,720,000 (Direct Cost: ¥34,400,000、Indirect Cost: ¥10,320,000)
Fiscal Year 2022: ¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2021: ¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2020: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Keywords合成生物学 / 生合成工学 / 酵素工学 / 天然物化学
Outline of Research at the Start

複雑骨格天然物の新奇な生合成マシナリーの詳細とその立体構造基盤の解明を目的とする。本研究では、人為的な機能制御と分子多様性創出の格好のモデルともいえる、強力なタンパクリン酸化酵素活性化作用を示すテレオシジンなど、テルペンインドール・アルカロイドとその関連化合物をとりあげる。有機化学を基盤として、その生合成反応機構の詳細を明らかにするとともに、酵素反応の立体構造基盤を解明する。加えて、酵素タンパクの立体構造情報に基づく合理的な触媒機能の改変により、さらなる分子多様性と新規骨格の創出をめざす。創薬研究の革新的ツールとなる超天然型新規生体触媒と創薬シード化合物の創製を実現する。

Outline of Final Research Achievements

The aim of this research was to elucidate the details of novel biosynthetic machineries of complex natural products and their three-dimensional structural basis. In this study, we focused on medicinal natural products such as alkaloids, terpenes, polyketides, peptides, and related compounds that are important as pharmaceutical resources. We clarified the details of their biosynthetic machineries at the enzymatic and genetic levels, and elucidated the mechanism and three-dimensional structural basis for the enzyme reactions. In addition, we succeeded in engineering the catalytic function of the enzyme protein based on its structural information to further expand molecular diversity and to create unnatural novel molecules. We have created novel supranatural biocatalysts and drug discovery seed compounds that will serve as innovative tools for synthetic biology and drug discovery research.

Academic Significance and Societal Importance of the Research Achievements

医薬資源として重要な天然物の骨格構築に関わる酵素の合理的な機能拡張と潜在的触媒能力を活用することにより、物質生産の可能性をさらに大きく広げることになる。本研究はその学術性が極めて高いのみならず、生合成研究が天然の秘められた新規化合物の発見を通して創薬研究などへも応用可能なことを示しており、天然物化学の新しい方法論の可能性を実証した。稀少有用物質の大量供給や、新規機能性分子の創出など、従来の有機合成によるプロセスに比べて、クリーンかつ経済的な新しい技術基盤として期待できることから、社会的にも意義があり、医薬品のみならず、エネルギー、新規素材の生産技術の革新に直結する。

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Comments on the Screening Results   Annual Research Report
  • Research Products

    (67 results)

All 2023 2022 2021 2020 Other

All Int'l Joint Research (8 results) Journal Article (45 results) (of which Int'l Joint Research: 34 results,  Peer Reviewed: 45 results,  Open Access: 19 results) Presentation (13 results) (of which Int'l Joint Research: 10 results,  Invited: 13 results) Remarks (1 results)

  • [Int'l Joint Research] 北京大学/武漢大学/浙江大学(中国)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] ボン大学/コンスタンツ大学(ドイツ)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] 曁南大学/浙江大学/中国科学院(中国)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] ボン大学/ライプツィヒ大学(ドイツ)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] ボストン大学/カリフォルニア大学/スクリプス研究所(米国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] ボン大学/チュービンゲン大学(ドイツ)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] 中国科学院/武漢大学/浙江大学(中国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] チェコ科学アカデミー(チェコ)

    • Related Report
      2020 Annual Research Report
  • [Journal Article] Structure-based engineering of α-ketoglutarate dependent oxygenases in fungal meroterpenoid biosynthesis2023

    • Author(s)
      Awakawa Takayoshi、Mori Takahiro、Ushimaru Richiro、Abe Ikuro
    • Journal Title

      Natural Product Reports

      Volume: 40 Issue: 1 Pages: 46-61

    • DOI

      10.1039/d2np00014h

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Orthoester formation in fungal meroterpenoid austalide F biosynthesis2023

    • Author(s)
      Awakawa Takayoshi、Liu Wei、Bai Tongxuan、Taniguchi Tomo、Abe Ikuro
    • Journal Title

      Philosophical Transactions of the Royal Society B: Biological Sciences

      Volume: 378 Issue: 1871 Pages: 1-6

    • DOI

      10.1098/rstb.2022.0037

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Discovery of non-squalene triterpenes2022

    • Author(s)
      Tao Hui、Lauterbach Lukas、Bian Guangkai、Chen Rong、Hou Anwei、Mori Takahiro、Cheng Shu、Hu Ben、Lu Li、Mu Xin、Li Min、Adachi Naruhiko、Kawasaki Masato、Moriya Toshio、Senda Toshiya、Wang Xinghuan、Deng Zixin、Abe Ikuro、Dickschat Jeroen S.、Liu Tiangang
    • Journal Title

      Nature

      Volume: 606 Issue: 7913 Pages: 414-419

    • DOI

      10.1038/s41586-022-04773-3

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Stereoselectivity and Substrate Specificity of the Fe(II)/α-Ketoglutarate-Dependent Oxygenase TqaL2022

    • Author(s)
      Tao Hui、Ushimaru Richiro、Awakawa Takayoshi、Mori Takahiro、Uchiyama Masanobu、Abe Ikuro
    • Journal Title

      Journal of the American Chemical Society

      Volume: 144 Issue: 47 Pages: 21512-21520

    • DOI

      10.1021/jacs.2c08116

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Molecular insights into the unusually promiscuous and catalytically versatile Fe(II)/α-ketoglutarate-dependent oxygenase SptF.2022

    • Author(s)
      Tao, H., # Mori, T., # Chen, H., Lyu, S., Nonoyama, A., Lee, S., Abe, I. (#equall contribution)
    • Journal Title

      Nature Commun

      Volume: 13 Issue: 1 Pages: 95-95

    • DOI

      10.1038/s41467-021-27636-3

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Noncanonical Functions of Enzyme Cofactors as Building Blocks in Natural Product Biosynthesis2022

    • Author(s)
      Barra Lena、Awakawa Takayoshi、Abe Ikuro
    • Journal Title

      JACS Au

      Volume: 2 Issue: 9 Pages: 1950-1963

    • DOI

      10.1021/jacsau.2c00391

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Identification of a diarylpentanoid-producing polyketide synthase revealing an unusual biosynthetic pathway of 2-(2-phenylethyl)chromones in agarwood2022

    • Author(s)
      Wang Xiao-Hui、Gao Bo-Wen、Nakashima Yu、Mori Takahiro、Zhang Zhong-Xiu、Kodama Takeshi、Lee Yuan-E、Zhang Ze-Kun、Wong Chin-Piow、Liu Qian-Qian、Qi Bo-Wen、Wang Juan、Li Jun、Liu Xiao、Abe Ikuro、Morita Hiroyuki、Tu Peng-Fei、Shi She-Po
    • Journal Title

      Nature Communications

      Volume: 13 Issue: 1 Pages: 348-348

    • DOI

      10.1038/s41467-022-27971-z

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Characterization of Enzymes Catalyzing the Initial Steps of the β-Lactam Tabtoxin Biosynthesis2022

    • Author(s)
      Lyu Jiaqi、Ushimaru Richiro、Abe Ikuro
    • Journal Title

      Organic Letters

      Volume: 24 Issue: 18 Pages: 3337-3341

    • DOI

      10.1021/acs.orglett.2c00878

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Structure-based redesign of Fe(<scp>ii</scp>)/2-oxoglutarate-dependent oxygenase AndA to catalyze spiro-ring formation2022

    • Author(s)
      Mori Takahiro、Nakashima Yu、Chen Heping、Hoshino Shotaro、Mitsuhashi Takaaki、Abe Ikuro
    • Journal Title

      Chemical Communications

      Volume: 58 Issue: 36 Pages: 5510-5513

    • DOI

      10.1039/d2cc00736c

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Rational Engineering of the Nonheme Iron- and 2-Oxoglutarate-Dependent Oxygenase SptF2022

    • Author(s)
      Mori Takahiro、Yu Ziheng、Tao Hui、Abe Ikuro
    • Journal Title

      Organic Letters

      Volume: 24 Issue: 8 Pages: 1737-1741

    • DOI

      10.1021/acs.orglett.2c00409

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cordycicadins A?D, Antifeedant Polyketides from the Entomopathogenic Fungus <i>Cordyceps cicadae</i> JXCH12022

    • Author(s)
      Li Xinyang、Chen He-Ping、Zhou Lin、Fan Jing、Awakawa Takayoshi、Mori Takahiro、Ushimaru Richiro、Abe Ikuro、Liu Ji-Kai
    • Journal Title

      Organic Letters

      Volume: 24 Issue: 47 Pages: 8627-8632

    • DOI

      10.1021/acs.orglett.2c03432

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Biosynthesis of dihydroxyardeemin by heterologous expression2022

    • Author(s)
      Zhou Lu、Abe Ikuro、Awakawa Takayoshi
    • Journal Title

      Tetrahedron

      Volume: 127 Pages: 133095-133095

    • DOI

      10.1016/j.tet.2022.133095

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Harnessing Fe(II)/α-ketoglutarate-dependent oxygenases for structural diversification of fungal meroterpenoids2022

    • Author(s)
      Tao Hui、Abe Ikuro
    • Journal Title

      Current Opinion in Biotechnology

      Volume: 77 Pages: 102763-102763

    • DOI

      10.1016/j.copbio.2022.102763

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Structural basis for endoperoxide-forming oxygenases2022

    • Author(s)
      Mori Takahiro、Abe Ikuro
    • Journal Title

      Beilstein Journal of Organic Chemistry

      Volume: 18 Pages: 707-721

    • DOI

      10.3762/bjoc.18.71

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Unusual Dioxygen-Dependent Reactions Catalyzed by Nonheme Iron Enzymes in Natural Product Biosynthesis2022

    • Author(s)
      Ushimaru Richiro、Abe Ikuro
    • Journal Title

      ACS Catalysis

      Volume: 13 Issue: 2 Pages: 1045-1076

    • DOI

      10.1021/acscatal.2c05247

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] β-NAD as a building block in natural product biosynthesis2021

    • Author(s)
      Barra Lena、Awakawa Takayoshi、Shirai Kohei、Hu Zhijuan、Bashiri Ghader、Abe Ikuro
    • Journal Title

      Nature

      Volume: 600 Issue: 7890 Pages: 754-758

    • DOI

      10.1038/s41586-021-04214-7

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Molecular insights into the endoperoxide formation by Fe(II)/α-KG-dependent oxygenase NvfI2021

    • Author(s)
      Mori Takahiro、Zhai Rui、Ushimaru Richiro、Matsuda Yudai、Abe Ikuro
    • Journal Title

      Nature Communications

      Volume: 12 Issue: 1 Pages: 4417-4417

    • DOI

      10.1038/s41467-021-24685-6

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Heterodimeric Non-heme Iron Enzymes in Fungal Meroterpenoid Biosynthesis2021

    • Author(s)
      Li Xinyang、Awakawa Takayoshi、Mori Takahiro、Ling Meiqi、Hu Dan、Wu Bin、Abe Ikuro
    • Journal Title

      Journal of the American Chemical Society

      Volume: 143 Issue: 50 Pages: 21425-21432

    • DOI

      10.1021/jacs.1c11548

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Stereodivergent Nitrocyclopropane Formation during Biosynthesis of Belactosins and Hormaomycins2021

    • Author(s)
      Shimo Shotaro、Ushimaru Richiro、Engelbrecht Alicia、Harada Mei、Miyamoto Kazunori、Kulik Andreas、Uchiyama Masanobu、Kaysser Leonard、Abe Ikuro
    • Journal Title

      Journal of the American Chemical Society

      Volume: 143 Issue: 44 Pages: 18413-18418

    • DOI

      10.1021/jacs.1c10201

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] C-Glycoside metabolism in the gut and in nature: Identification, characterization, structural analyses and distribution of C-C bond-cleaving enzymes2021

    • Author(s)
      Mori Takahiro、Kumano Takuto、He Haibing、Watanabe Satomi、Senda Miki、Moriya Toshio、Adachi Naruhiko、Hori Sanae、Terashita Yuzu、Kawasaki Masato、Hashimoto Yoshiteru、Awakawa Takayoshi、Senda Toshiya、Abe Ikuro、Kobayashi Michihiko
    • Journal Title

      Nature Communications

      Volume: 12 Issue: 1 Pages: 6294-6294

    • DOI

      10.1038/s41467-021-26585-1

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Aziridine Formation by a Fe <sup>II</sup> /α‐Ketoglutarate Dependent Oxygenase and 2‐Aminoisobutyrate Biosynthesis in Fungi2021

    • Author(s)
      Bunno Reito、Awakawa Takayoshi、Mori Takahiro、Abe Ikuro
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 60 Issue: 29 Pages: 15827-15831

    • DOI

      10.1002/anie.202104644

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] One Polyketide Synthase, Two Distinct Products: Trans‐Acting Enzyme‐Controlled Product Divergence in Calbistrin Biosynthesis2021

    • Author(s)
      Tao Hui、Mori Takahiro、Wei Xingxing、Matsuda Yudai、Abe Ikuro
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 60 Issue: 16 Pages: 8851-8858

    • DOI

      10.1002/anie.202016525

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Structural Basis for Isomerization Reactions in Fungal Tetrahydroxanthone Biosynthesis and Diversification2021

    • Author(s)
      Yang Jiali、Mori Takahiro、Wei Xingxing、Matsuda Yudai、Abe Ikuro
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 60 Issue: 35 Pages: 19458-19465

    • DOI

      10.1002/anie.202107884

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Insights into phosphatase-activated chemical defense in a marine sponge holobiont2021

    • Author(s)
      Jomori Takahiro、Matsuda Kenichi、Egami Yoko、Abe Ikuro、Takai Akira、Wakimoto Toshiyuki
    • Journal Title

      RSC Chemical Biology

      Volume: 2 Issue: 6 Pages: 1600-1607

    • DOI

      10.1039/d1cb00163a

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Chemistry of fungal meroterpenoid cyclases2021

    • Author(s)
      Barra Lena、Abe Ikuro
    • Journal Title

      Natural Product Reports

      Volume: 38 Issue: 3 Pages: 566-585

    • DOI

      10.1039/d0np00056f

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Enzymology and biosynthesis of the orsellinic acid derived medicinal meroterpenoids2021

    • Author(s)
      Tao Hui、Abe Ikuro
    • Journal Title

      Current Opinion in Biotechnology

      Volume: 69 Pages: 52-59

    • DOI

      10.1016/j.copbio.2020.11.016

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Biosynthesis of alkyne-containing natural products2021

    • Author(s)
      Li Xinyang、Lv Jian-Ming、Hu Dan、Abe Ikuro
    • Journal Title

      RSC Chemical Biology

      Volume: 2 Issue: 1 Pages: 166-180

    • DOI

      10.1039/d0cb00190b

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Reconstitution of Polyketide-Derived Meroterpenoid Biosynthetic Pathway in Aspergillus oryzae2021

    • Author(s)
      Awakawa Takayoshi、Abe Ikuro
    • Journal Title

      Journal of Fungi

      Volume: 7 Issue: 6 Pages: 486-486

    • DOI

      10.3390/jof7060486

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Biosynthesis of sulfonamide and sulfamate antibiotics in Actinomycete2021

    • Author(s)
      Awakawa Takayoshi、Barra Lena、Abe Ikuro
    • Journal Title

      Journal of Industrial Microbiology and Biotechnology

      Volume: 48 Issue: 3-4 Pages: 001-001

    • DOI

      10.1093/jimb/kuab001

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Enzymatic Formation of Indolactam Scaffold by C-N Bond‐Forming Cytochrome P450 Oxidases in Teleocidin Biosynthesis2020

    • Author(s)
      Morita Iori、Mori Takahiro、Abe Ikuro
    • Journal Title

      Chemistry A European Journal

      Volume: 27 Issue: 9 Pages: 2963-2972

    • DOI

      10.1002/chem.202003899

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Extensive expanding the chemical diversity of fusidane-type antibiotics using a stochastic combinational strategy2020

    • Author(s)
      Song Xiaojun、Lv Jianming、Cao Zhiqin、Huang Huiyun、Chen Guodong、Awakawa Takayoshi、Hu Dan、Gao Hao、Abe Ikuro、Yao Xinsheng
    • Journal Title

      Acta Pharmaceutica Sinica B

      Volume: 10 Issue: 6 Pages: 1676-1685

    • DOI

      10.1016/j.apsb.2020.12.007

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Exploiting a C-N Bond Forming Cytochrome?P450 Monooxygenase for C?S Bond Formation2020

    • Author(s)
      Morita Iori、Mori Takahiro、Mitsuhashi Takaaki、Hoshino Shotaro、Taniguchi Yoshimasa、Kikuchi Takashi、Nagae Kei、Nasu Norihiro、Fujita Makoto、Ohwada Tomohiko、Abe Ikuro
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 59 Issue: 10 Pages: 3988-3993

    • DOI

      10.1002/anie.201916269

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Exploiting the Potential of Meroterpenoid Cyclases to Expand the Chemical Space of Fungal Meroterpenoids2020

    • Author(s)
      Mitsuhashi Takaaki、Barra Lena、Powers Zachary、Kojasoy Volga、Cheng Andrea、Yang Feng、Taniguchi Yoshimasa、Kikuchi Takashi、Fujita Makoto、Tantillo Dean J.、Porco John A.、Abe Ikuro
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 59 Issue: 52 Pages: 23772-23781

    • DOI

      10.1002/anie.202011171

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Heterochiral coupling in non-ribosomal peptide macrolactamization2020

    • Author(s)
      Matsuda Kenichi、Zhai Rui、Mori Takahiro、Kobayashi Masakazu、Sano Ayae、Abe Ikuro、Wakimoto Toshiyuki
    • Journal Title

      Nature Catalysis

      Volume: 3 Issue: 6 Pages: 507-515

    • DOI

      10.1038/s41929-020-0456-7

    • NAID

      120006941707

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Acyltransferase that catalyses the condensation of polyketide and peptide moieties of goadvionin hybrid lipopeptides2020

    • Author(s)
      Kozakai Ryosuke、Ono Takuto、Hoshino Shotaro、Takahashi Hidenori、Katsuyama Yohei、Sugai Yoshinori、Ozaki Taro、Teramoto Kazuya、Teramoto Kanae、Tanaka Koichi、Abe Ikuro、Asamizu Shumpei、Onaka Hiroyasu
    • Journal Title

      Nature Chemistry

      Volume: 12 Issue: 9 Pages: 869-877

    • DOI

      10.1038/s41557-020-0508-2

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biosynthesis of biscognienyne B involving an unprecedented cytochrome P450‐dependent alkynylation2020

    • Author(s)
      Abe Ikuro、Lv Jian-Ming、Gao Yao-Hui、Zhao Huan、Awakawa Takayoshi、Liu Ling、Chen Guo-Dong、Yao Xin-Sheng、Hu Dan、Gao Hao
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 59 Issue: 32 Pages: 13531-13536

    • DOI

      10.1002/anie.202004364

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Discovery of the cryptic function of terpene cyclases as aromatic prenyltransferases2020

    • Author(s)
      He Haibing、Bian Guangkai、Herbst-Gervasoni Corey J.、Mori Takahiro、Shinsky Stephen A.、Hou Anwei、Mu Xin、Huang Minjian、Cheng Shu、Deng Zixin、Christianson David W.、Abe Ikuro、Liu Tiangang
    • Journal Title

      Nature Communications

      Volume: 11 Issue: 1 Pages: 3958-3958

    • DOI

      10.1038/s41467-020-17642-2

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Identification and characterization of N9-methyltransferase involved in converting caffeine into non-stimulatory theacrine in tea2020

    • Author(s)
      Zhang Yue-Hong、Li Yi-Fang、Wang Yongjin、Tan Li、Cao Zhi-Qin、Xie Chao、Xie Guo、Gong Hai-Biao、Sun Wan-Yang、Ouyang Shu-Hua、Duan Wen-Jun、Lu Xiaoyun、Ding Ke、Kurihara Hiroshi、Hu Dan、Zhang Zhi-Min、Abe Ikuro、He Rong-Rong
    • Journal Title

      Nature Communications

      Volume: 11 Issue: 1 Pages: 1473-1473

    • DOI

      10.1038/s41467-020-15324-7

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Structural Diversification of Andiconin-Derived Natural Products by α-Ketoglutarate-Dependent Dioxygenases2020

    • Author(s)
      Bai Tongxuan、Matsuda Yudai、Tao Hui、Mori Takahiro、Zhang Yonghui、Abe Ikuro
    • Journal Title

      Organic Letters

      Volume: 22 Issue: 11 Pages: 4311-4315

    • DOI

      10.1021/acs.orglett.0c01358

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Sporormielones A?E, bioactive novel C?C coupled orsellinic acid derivative dimers, and their biosynthetic origin2020

    • Author(s)
      Chen Guo-Dong、Hu Dan、Huang Mei-Juan、Tang Jia、Wang Xiao-Xia、Zou Jian、Xie Jun、Zhang Wei-Guang、Guo Liang-Dong、Yao Xin-Sheng、Abe Ikuro、Gao Hao
    • Journal Title

      Chemical Communications

      Volume: 56 Issue: 33 Pages: 4607-4610

    • DOI

      10.1039/d0cc00855a

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Deciphering the Biosynthetic Mechanism of Pelletierine in Lycopodium Alkaloid Biosynthesis2020

    • Author(s)
      Wang Juan、Zhang Ze-Kun、Jiang Fang-Fang、Qi Bo-Wen、Ding Ning、Hnin Saw Yu Yu、Liu Xiao、Li Jun、Wang Xiao-hui、Tu Peng-Fei、Abe Ikuro、Morita Hiroyuki、Shi She-Po
    • Journal Title

      Organic Letters

      Volume: 22 Issue: 21 Pages: 8725-8729

    • DOI

      10.1021/acs.orglett.0c03339

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Total Synthesis and Structural Revision of Kasumigamide, and Identification of a New Analogue2020

    • Author(s)
      Kuranaga Takefumi、Matsuda Kenichi、Takaoka Masachika、Tachikawa Chisato、Sano Ayae、Itoh Kosei、Enomoto Ayumu、Fujita Kei、Abe Ikuro、Wakimoto Toshiyuki
    • Journal Title

      ChemBioChem

      Volume: 21 Issue: 23 Pages: 3329-3332

    • DOI

      10.1002/cbic.202000409

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular Basis for Sesterterpene Diversity Produced by Plant Terpene Synthases2020

    • Author(s)
      Chen Qingwen、Li Jianxu、Liu Zhixi、Mitsuhashi Takaaki、Zhang Yuting、Liu Haili、Ma Yihua、He Juan、Shinada Tetsuro、Sato Tsutomu、Wang Yong、Liu Hongwei、Abe Ikuro、Zhang Peng、Wang Guodong
    • Journal Title

      Plant Communications

      Volume: 1 Issue: 5 Pages: 100051-100051

    • DOI

      10.1016/j.xplc.2020.100051

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Fungal Meroterpenoids2020

    • Author(s)
      Matsuda Yudai、Abe Ikuro
    • Journal Title

      Comprehensive Natural Products III: Chemistry and Biology

      Volume: 1 Pages: 445-478

    • DOI

      10.1016/b978-0-12-409547-2.14663-3

    • ISBN
      9780081026915
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sesterterpenoids2020

    • Author(s)
      Mitsuhashi Takaaki、Abe Ikuro
    • Journal Title

      Progress in the Chemistry of Organic Natural Products,

      Volume: 111 Pages: 1-79

    • DOI

      10.1007/978-3-030-37865-3_1

    • ISBN
      9783030378646, 9783030378653
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Presentation] Unusual Enzyme Reactions in Natural Product Biosynthesis2023

    • Author(s)
      Ikuro Abe
    • Organizer
      4th International Conference on Natural Product Discovery and Development in the Genomic Era, San Diego, USA,
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Unusual Enzyme Reactions in Natural Product Biosynthesis2023

    • Author(s)
      Ikuro Abe
    • Organizer
      PSJ-PSK Joint Symposium: Natural Products in Drug Discovery, the 143rd Annual Meeting of the Pharmaceutical Society of Japan, Sapporo, Japan
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] NAD as a Building Block in Natural Product Biosynthesis2022

    • Author(s)
      Ikuro Abe
    • Organizer
      Directing Biosynthesis VI, Edinburgh, UK
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Molecular Basis for the P450-catalyzed C-N Bond Formation in Indolactam Biosynthesis2022

    • Author(s)
      Ikuro Abe
    • Organizer
      International Conference on Cytochrome P450, Washington, D.C., USA
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Unusual Enzyme Reactions in Natural Product Biosynthesis2022

    • Author(s)
      Ikuro Abe
    • Organizer
      Gordon Research Conference, Natural Products and Bioactive Compounds, Proctor Academy, NH, USA
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] NAD as a Building Block in Natural Product Biosynthesis2022

    • Author(s)
      Ikuro Abe
    • Organizer
      15th Asian Congress on Biotechnology, Bali, Indonesia
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] NAD as a Building Block in Natural Product Biosynthesis2022

    • Author(s)
      Ikuro Abe
    • Organizer
      29th Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB) Conference & 2022 Chinese Society of Biochemistry and Molecular Biology Conference, Shenzhen (Online), China
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Unusual Enzyme Reactions in Natural Product Biosynthesis2022

    • Author(s)
      Ikuro Abe
    • Organizer
      4th Lijiang International Forum on Pharmaceutical Sciences, Guiling (Online), China
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Unusual Enzyme Reactions in Natural Product Biosynthesis2022

    • Author(s)
      Ikuro Abe
    • Organizer
      Conference on Synthetic Biology Approaches and its Applications, Osaka (Online), Japan
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 人工生合成マシナリーの合理的再構築による次世代天然物化学2022

    • Author(s)
      阿部郁朗
    • Organizer
      科学研究費補助金 新学術領域研究(研究領域提案型)生物合成系の再設計による複雑骨格機能分子の革新的創成科学、取りまとめ公開シンポジウム、オンライン
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 天然物生合成マシナリーの合理的再構築による次世代天然物創薬2021

    • Author(s)
      阿部郁朗
    • Organizer
      第23回天然薬物の開発と応用シンポジウム、北海道大学、札幌
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Unique enzyme Reactions in Natural Product Biosynthesi2021

    • Author(s)
      Ikuro Abe
    • Organizer
      9th Yangtze River Delta Marine Biomedicine International Forum” (YRDMB 2021), Nanjing (Online), China
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 非ヘム鉄-αケトグルタル酸依存性酸化酵素に関する研究2020

    • Author(s)
      阿部郁朗
    • Organizer
      第22回 生体触媒シンポジウム
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Remarks] 東京大学大学院薬学系研究科天然物化学教室

    • URL

      https://tennen.f.u-tokyo.ac.jp/head.htm

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report 2020 Annual Research Report

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Published: 2020-04-28   Modified: 2024-01-30  

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