Multiscale data analysis of brain disease models for brain disease elucidation and drug discovery

• Project/Area Number: 20H00492
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Medium-sized Section 47:Pharmaceutical sciences and related fields
• Research Institution: Osaka University
• Principal Investigator: Hashimoto Hitoshi 大阪大学, 大学院薬学研究科, 教授 (30240849)
• Co-Investigator(Kenkyū-buntansha): 笠井 淳司 大阪大学, 大学院薬学研究科, 准教授 (40454649) ; 勢力 薫 大阪大学, 大学院薬学研究科, 助教 (90802918)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2023)
• Budget Amount: ¥45,630,000 (Direct Cost: ¥35,100,000、Indirect Cost: ¥10,530,000); Fiscal Year 2022: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000); Fiscal Year 2021: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000); Fiscal Year 2020: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
• Keywords: 全脳イメージング / FAST / マルチスケール / 脳疾患 / 創薬 / 精神疾患モデル / ストレス / 前障 / 前頭前皮質 / マルチスケールデータ解析 / 全脳 / 精神疾患 / 超解像

Outline of Research at the Start

本研究では、脳疾患と脳神経機能の発現機構の解析に貢献する観察・操作技術横断的な研究を推進するため、広範な空間分解能画像と細胞標識レポーターを用いた高精細・脳領域・細胞アトラスの構築、それらに基づく１細胞ゲノミクスや神経活動の解析等を実施し、得られたデータを再び脳地図に統合して、正常脳と病態脳をアンバイアスに比較解析する方法を構築する。また、申請者らが作製した脳疾患モデルマウス等の時・空間に統合された脳情報を基に、行動変化、神経化学・生理学的変化との関連や因果関係をアンバイアスで多角的に探索する。以上により脳疾患の生物学的理解、診断・治療薬の開発と脳の仕組みの理解に寄与する。

Outline of Final Research Achievements

We aimed to improve our whole-brain imaging system block-FAce Serial microscopy Tomography (FAST) and to promote research on observation and manipulation techniques that contribute to the analysis of brain diseases and the mechanisms of central nervous system function. To this end, we have developed a method for unbiased comparative analysis of normal and diseased brains using cellular-level spatial resolution imaging, image analysis segmented by brain region, and machine learning. By combining FAST technology with advanced neuroscience research methods, we have promoted brain research that is not necessarily dependent on conventional hypotheses or theories, such as discovering new pathogenic mechanisms and treatments for stress-related disorders, including anxiety and depression.

Academic Significance and Societal Importance of the Research Achievements

本研究において、全脳構造・活動を網羅的かつアンバイアスに個体間で比較解析するFAST技術を高度化し、さらにFASTと先端的な脳科学研究手法を組合せ、従来の仮説や定説に必ずしも依らない脳研究を推進し、幾つかの新たな仮説の起点を提示することができた。本研究は、神経科学の領域において独自性が高く、国内外の様々な研究分野に影響を与えるとともに、今後同様な研究方法が活用されることが期待される。

Research Products

• [Int'l Joint Research] University of California Los Angeles/California Institute of Technology(米国)
• [Journal Article] Clozapine Induces Neuronal Activation in the Medial Prefrontal Cortex in a Projection Target-Biased Manner (2024)
  • Author(s): Yumi Hirato, Kaoru Seiriki, Leo Kojima, Shohei Yamada, Hiroki Rokujo, Tomoya Takemoto, Takanobu Nakazawa, Atsushi Kasai, Hitoshi Hashimoto
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 47 Issue: 2 Pages: 478-485
  • DOI: 10.1248/bpb.b23-00898
  • ISSN: 0918-6158, 1347-5215
  • Year and Date: 2024-02-22
  • Peer Reviewed / Open Access
• [Journal Article] Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment (2024)
  • Author(s): Hideo Hagihara、Takao Keizo、他129名
  • Journal Title: eLife Volume: 12 Pages: 89376-89376
  • DOI: 10.7554/elife.89376
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Blockade of vasoactive intestinal peptide receptor 2 (VIPR2) signaling suppresses cyclin D1-dependent cell-cycle progression in MCF-7 cells (2024)
  • Author(s): Asano Satoshi、Ono Ami、Baba Kaede、Uehara Teru、Sakamoto Kotaro、Hayata-Takano Atsuko、Nakazawa Takanobu、Yanamoto Souichi、Tanimoto Kotaro、Hashimoto Hitoshi、Ago Yukio
  • Journal Title: Journal of Pharmacological Sciences Volume: 154 Issue: 3 Pages: 139-147
  • DOI: 10.1016/j.jphs.2024.01.002
  • Peer Reviewed / Open Access
• [Journal Article] (R)-ketamine restores anterior insular cortex activity and cognitive deficits in social isolation-reared mice (2024)
  • Author(s): Yokoyama Rei、Ago Yukio、Igarashi Hisato、Higuchi Momoko、Tanuma Masato、Shimazaki Yuto、Kawai Takafumi、Seiriki Kaoru、Hayashida Misuzu、Yamaguchi Shun、Tanaka Hirokazu、Nakazawa Takanobu、Okamura Yasushi、Hashimoto Kenji、Kasai Atsushi、Hashimoto Hitoshi
  • Journal Title: Molecular Psychiatry Volume: - Issue: 5 Pages: 1-11
  • DOI: 10.1038/s41380-024-02419-6
  • Peer Reviewed / Open Access
• [Journal Article] Long-lasting anti-despair and anti-anhedonia effects of (S)-norketamine in social isolation-reared mice (2024)
  • Author(s): Yokoyama Rei、Higuchi Momoko、Tanabe Wataru、Tsukada Shinji、Igarashi Hisato、Seiriki Kaoru、Nakazawa Takanobu、Kasai Atsushi、Ago Yukio、Hashimoto Hitoshi
  • Journal Title: Journal of Pharmacological Sciences Volume: 154 Issue: 2 Pages: 72-76
  • DOI: 10.1016/j.jphs.2023.12.005
  • Peer Reviewed / Open Access
• [Journal Article] Activity-dependent organization of prefrontal hub-networks for associative learning and signal transformation (2023)
  • Author(s): Agetsuma Masakazu、Sato Issei、Tanaka Yasuhiro R.、Carrillo-Reid Luis、Kasai Atsushi、Noritake Atsushi、Arai Yoshiyuki、Yoshitomo Miki、Inagaki Takashi、Yukawa Hiroshi、Hashimoto Hitoshi、Nabekura Junichi、Nagai Takeharu
  • Journal Title: Nature Communications Volume: 14 Issue: 1 Pages: 5996-5996
  • DOI: 10.1038/s41467-023-41547-5
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Pituitary adenylate cyclase-activating polypeptide deficient mice show length abnormalities of the axon initial segment (2023)
  • Author(s): Iwahashi Misaki、Yoshimura Takeshi、Harigai Wakana、Takuma Kazuhiro、Hashimoto Hitoshi、Katayama Taiichi、Hayata-Takano Atsuko
  • Journal Title: Journal of Pharmacological Sciences Volume: 153 Issue: 3 Pages: 175-182
  • DOI: 10.1016/j.jphs.2023.08.006
  • Peer Reviewed / Open Access
• [Journal Article] High-throughput line-illumination Raman microscopy with multislit detection (2023)
  • Author(s): Mochizuki Kentaro、Kumamoto Yasuaki、Maeda Shunsuke、Tanuma Masato、Kasai Atsushi、Takemura Masashi、Harada Yoshinori、Hashimoto Hitoshi、Tanaka Hideo、Smith Nicholas Isaac、Fujita Katsumasa
  • Journal Title: Biomedical Optics Express Volume: 14 Issue: 3 Pages: 1015-1015
  • DOI: 10.1364/boe.480611
  • Peer Reviewed / Open Access
• [Journal Article] Effect of PACAP on Heat Exposure (2023)
  • Author(s): Suzuki Keisuke、Yamaga Hiroki、Ohtaki Hirokazu、Hirako Satoshi、Miyamoto Kazuyuki、Nakamura Motoyasu、Yanagisawa Kaoru、Shimada Takuya、Hosono Tomohiko、Hashimoto Hitoshi、Honda Kazuho、Dohi Kenji
  • Journal Title: International Journal of Molecular Sciences Volume: 24 Issue: 4 Pages: 3992-3992
  • DOI: 10.3390/ijms24043992
  • Peer Reviewed / Open Access
• [Journal Article] Dorsal raphe serotonergic neurons preferentially reactivate dorsal dentate gyrus cell ensembles associated with positive experience (2023)
  • Author(s): Nagai Yuma、Kisaka Yuri、Nomura Kento、Nishitani Naoya、Andoh Chihiro、Koda Masashi、Kawai Hiroyuki、Seiriki Kaoru、Nagayasu Kazuki、Kasai Atsushi、Shirakawa Hisashi、Nakazawa Takanobu、Hashimoto Hitoshi、Kaneko Shuji
  • Journal Title: Cell Reports Volume: 42 Issue: 3 Pages: 112149-112149
  • DOI: 10.1016/j.celrep.2023.112149
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Overexpression of VIPR2 in mice results in microencephaly with paradoxical increased white matter volume (2023)
  • Author(s): Ago Y, Van C, Condro MC, Hrncir H, Diep AL, Rajbhandari AK, Fanselow MS, Hashimoto H, MacKenzie-Graham AJ, Waschek JA
  • Journal Title: Experimental Neurology Volume: 362 Pages: 114339-114339
  • DOI: 10.1016/j.expneurol.2023.114339
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Vasoactive intestinal peptide receptor 2 signaling promotes breast cancer cell proliferation by enhancing the ERK pathway (2023)
  • Author(s): Asano Satoshi、Ono Ami、Sakamoto Kotaro、Hayata-Takano Atsuko、Nakazawa Takanobu、Tanimoto Kotaro、Hashimoto Hitoshi、Ago Yukio
  • Journal Title: Peptides Volume: 161 Pages: 170940-170940
  • DOI: 10.1016/j.peptides.2023.170940
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Pre-treatment of oncolytic reovirus improves tumor accumulation and intratumoral distribution of PEG-liposomes (2023)
  • Author(s): Eguchi Maho、Hirata Seiya、Ishigami Ikuho、Shuwari Naomi、Ono Ryosuke、Tachibana Masashi、Tanuma Masato、Kasai Atsushi、Hashimoto Hitoshi、Ogawara Ken-ichi、Mizuguchi Hiroyuki、Sakurai Fuminori
  • Journal Title: Journal of Controlled Release Volume: 354 Pages: 35-44
  • DOI: 10.1016/j.jconrel.2022.12.050
  • Peer Reviewed / Open Access
• [Journal Article] Roles of the monoaminergic system in the antidepressant effects of ketamine and its metabolites (2023)
  • Author(s): Ago Y, Yokoyama R, Asano S, Hashimoto H
  • Journal Title: Neuropharmacology Volume: 223 Pages: 109313-109313
  • DOI: 10.1016/j.neuropharm.2022.109313
  • Peer Reviewed / Open Access
• [Journal Article] Parabrachial-to-parasubthalamic nucleus pathway mediates fear-induced suppression of feeding in male mice (2022)
  • Author(s): Nagashima Takashi、Tohyama Suguru、Mikami Kaori、Nagase Masashi、Morishima Mieko、Kasai Atsushi、Hashimoto Hitoshi、Watabe Ayako M.
  • Journal Title: Nature Communications Volume: 13 Issue: 1 Pages: 1-17
  • DOI: 10.1038/s41467-022-35634-2
  • Peer Reviewed / Open Access
• [Journal Article] Acute social defeat stress activated neurons project to the claustrum and basolateral amygdala (2022)
  • Author(s): Tanuma Masato、Niu Misaki、Ohkubo Jin、Ueno Hiroki、Nakai Yuka、Yokoyama Yoshihisa、Seiriki Kaoru、Hashimoto Hitoshi、Kasai Atsushi
  • Journal Title: Molecular Brain Volume: 15 Issue: 1 Pages: 100-100
  • DOI: 10.1186/s13041-022-00987-8
  • Peer Reviewed / Open Access
• [Journal Article] Molecular basis of astrocyte diversity and morphology across the CNS in health and disease (2022)
  • Author(s): Endo F, Kasai A, Soto JS, Yu X, Qu Z, Hashimoto H, Gradinaru V, Kawaguchi R, Khakh BS.
  • Journal Title: Science Volume: 378 Issue: 6619
  • DOI: 10.1126/science.adc9020
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The Pivotal Role of Neuropeptide Crosstalk from Ventromedial-PACAP to Dorsomedial-Galanin in the Appetite Regulation in the Mouse Hypothalamus (2022)
  • Author(s): Kambe Yuki、Nguyen Thanh Trung、Yasaka Toshiharu、Nguyen Thu Thi、Sameshima Yoshimune、Hashiguchi Kohei、Shintani Norihito、Hashimoto Hitoshi、Kurihara Takashi、Miyata Atsuro
  • Journal Title: Molecular Neurobiology Volume: 60 Issue: 1 Pages: 171-182
  • DOI: 10.1007/s12035-022-03084-y
  • Peer Reviewed / Open Access
• [Journal Article] Vasoactive intestinal peptide?VIPR2 signaling regulates tumor cell migration (2022)
  • Author(s): Asano Satoshi、Yamasaka Misa、Ozasa Kairi、Sakamoto Kotaro、Hayata-Takano Atsuko、Nakazawa Takanobu、Hashimoto Hitoshi、Waschek James A.、Ago Yukio
  • Journal Title: Frontiers in Oncology Volume: 12 Pages: 852358-852358
  • DOI: 10.3389/fonc.2022.852358
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Epigenetic and neuronal activity markers suggest the recruitment of the prefrontal cortex and hippocampus in the three-hit model of depression in male PACAP heterozygous mice (2022)
  • Author(s): Gaszner Tamas、Farkas Jozsef、Kun Daniel、Ujvari Balazs、Furedi Nora、Kovacs Laszlo Akos、Hashimoto Hitoshi、Reglodi Dora、Kormos Viktoria、Gaszner Balazs
  • Journal Title: International Journal of Molecular Sciences Volume: 23 Issue: 19 Pages: 11739-11739
  • DOI: 10.3390/ijms231911739
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Fluoxetine treatment supports predictive validity of the three hit model of depression in male PACAP heterozygous mice and underpins the impact of early life adversity on therapeutic efficacy (2022)
  • Author(s): Gaszner Tamas、Farkas Jozsef、Kun Daniel、Ujvari Balazs、Berta Gergely、Csernus Valer、Furedi Nora、Kovacs Laszlo Akos、Hashimoto Hitoshi、Reglodi Dora、Kormos Viktoria、Gaszner Balazs
  • Journal Title: Frontiers in Endocrinology Volume: 13
  • DOI: 10.3389/fendo.2022.995900
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Small-molecule non-peptide antagonists of the PACAP receptor attenuate acute restraint stress-induced anxiety-like behaviors in mice (2022)
  • Author(s): Shintani Yusuke、Hayata-Takano Atsuko、Yamano Yui、Ikuta Mankato、Takeuchi Rei、Takuma Kazuhiro、Okada Takuya、Toyooka Naoki、Takasaki Ichiro、Miyata Atsuro、Kurihara Takashi、Hashimoto Hitoshi
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 631 Pages: 146-151
  • DOI: 10.1016/j.bbrc.2022.09.079
  • Peer Reviewed / Open Access
• [Journal Article] Oxytocin ameliorates impaired social behavior in a mouse model of 3q29 deletion syndrome (2022)
  • Author(s): Takemoto Tomoya、Baba Masayuki、Yokoyama Kazumasa、Kitagawa Kohei、Nagayasu Kazuki、Ago Yukio、Seiriki Kaoru、Hayata-Takano Atsuko、Kasai Atsushi、Mori Daisuke、Ozaki Norio、Takuma Kazuhiro、Hashimoto Ryota、Hashimoto Hitoshi、Nakazawa Takanobu
  • Journal Title: Molecular Brain Volume: 15 Issue: 1 Pages: 26-26
  • DOI: 10.1186/s13041-022-00915-w
  • Peer Reviewed / Open Access
• [Journal Article] Autism-associated ANK2 regulates embryonic neurodevelopment (2022)
  • Author(s): Kawano Shotaro、Baba Masayuki、Fukushima Hotaka、Miura Daiki、Hashimoto Hitoshi、Nakazawa Takanobu
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 605 Pages: 45-50
  • DOI: 10.1016/j.bbrc.2022.03.058
  • Peer Reviewed / Open Access
• [Journal Article] Claustrum mediates bidirectional and reversible control of stress-induced anxiety responses. (2022)
  • Author(s): Niu M, Kasai A, Tanuma M, Seiriki K, Igarashi H, Kuwaki T, Nagayasu K, Miyaji K, Ueno H, Tanabe W, Seo K, Yokoyama R, Ohkubo J, Ago Y, Hayashida M, Inoue KI, Takada M, Yamaguchi S, Nakazawa T, Kaneko S, Okuno H, Yamanaka A, Hashimoto H.
  • Journal Title: Science Advances Volume: 8 Issue: 11
  • DOI: 10.1126/sciadv.abi6375
  • Peer Reviewed / Open Access
• [Journal Article] Altered Functional Connectivity of the Orbital Cortex and Striatum Associated with Catalepsy Induced by Dopamine D1 and D2 Antagonists (2021)
  • Author(s): Misaki Niu, Atsushi Kasai, Kaoru Seiriki, Misuzu Hayashida, Masato Tanuma, Rei Yokoyama, Yumi Hirato, Hitoshi Hashimoto
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 44 Issue: 3 Pages: 442-447
  • DOI: 10.1248/bpb.b20-01006
  • NAID: 130007993460
  • ISSN: 0918-6158, 1347-5215
  • Year and Date: 2021-03-01
  • Peer Reviewed / Open Access
• [Journal Article] Intranasal oxytocin administration ameliorates social behavioral deficits in a POGZWT/Q1038R mouse model of autism spectrum disorder (2021)
  • Author(s): Kitagawa Kohei、Matsumura Kensuke、Baba Masayuki、Kondo Momoka、Takemoto Tomoya、Nagayasu Kazuki、Ago Yukio、Seiriki Kaoru、Hayata-Takano Atsuko、Kasai Atsushi、Takuma Kazuhiro、Hashimoto Ryota、Hashimoto Hitoshi、Nakazawa Takanobu
  • Journal Title: Molecular Brain Volume: 14 Issue: 1 Pages: 56-56
  • DOI: 10.1186/s13041-021-00769-8
  • Peer Reviewed / Open Access
• [Journal Article] (S)-norketamine and (2S, 6S)-hydroxynorketamine Exert Potent Antidepressant-Like Effects in a Chronic Corticosterone-Induced Mouse Model of Depression (2020)
  • Author(s): 横山 玲、樋口 桃子、田邊 航、塚田 信司、内藤 恵、Lu Chen、笠井 淳司、勢力 薫、中澤 敬信、中川 晋作、橋本 謙二、橋本 均、吾郷 由希夫
  • Journal Title: Pharmacology Biochemistry and Behavior Volume: 191 Pages: 172876-172876
  • DOI: 10.1016/j.pbb.2020.172876
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Pathogenic POGZ mutation causes impaired cortical development and reversible autism-like phenotypes. (2020)
  • Author(s): Matsumura K, (33名中略）, Hashimoto R, (37名中35番目）,Hashimoto H, Nakazawa T.
  • Journal Title: Nat. Commun Volume: 11(1) Issue: 1 Pages: 859-859
  • DOI: 10.1038/s41467-020-14697-z
  • Peer Reviewed / Open Access
• [Journal Article] Direct visualization of an antidepressant analog using surface-enhanced Raman scattering in the brain (2020)
  • Author(s): Masato Tanuma, Atsushi Kasai, Kazuki Bando, Naoyuki Kotoku, Kazuo Harada, Masafumi Minoshima, Kosuke Higashino, Atsushi Kimishima, Masayoshi Arai, Yukio Ago, Kaoru Seiriki, Kazuya Kikuchi, Satoshi Kawata, Katsumasa Fujita, Hitoshi Hashimoto
  • Journal Title: JCI Insight Volume: 5 Issue: 6
  • DOI: 10.1172/jci.insight.133348
  • Peer Reviewed / Open Access
• [Journal Article] Activation of the VPAC2 Receptor Impairs Axon Outgrowth and Decreases Dendritic Arborization in Mouse Cortical Neurons by a PKA-Dependent Mechanism (2020)
  • Author(s): Takeuchi Shuto、Kawanai Takuya、Yamauchi Ryosuke、Chen Lu、Miyaoka Tatsunori、Yamada Mei、Asano Satoshi、Hayata-Takano Atsuko、Nakazawa Takanobu、Yano Koji、Horiguchi Naotaka、Nakagawa Shinsaku、Takuma Kazuhiro、Waschek James A.、Hashimoto Hitoshi、Ago Yukio
  • Journal Title: Frontiers in Neuroscience Volume: 14 Pages: 521-532
  • DOI: 10.3389/fnins.2020.00521
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Lipocalin-type prostaglandin D synthase regulates light-induced phase advance of the central circadian rhythm in mice (2020)
  • Author(s): Kawaguchi, C., Shintani, N., Hayata-Takano, A., Hatanaka, M., Kuromi, A., Nakamura, R., Yamano, Y., Shintani, Y., Nagai, K., Tsuchiya, S., Sugimoto, Y., Ichikawa, A., Okuno, Y., Urade, Y., Hirai, H., Nagata, K., Nakamura, M., Narumiya, S., Nakazawa, T., Kasai, A., Ago, Y., Takuma, K., Baba, A., and Hashimoto, H.
  • Journal Title: Communications Biology Volume: 3 Issue: 1 Pages: 557-557
  • DOI: 10.1038/s42003-020-01281-w
  • Peer Reviewed / Open Access
• [Presentation] 社会的敗北ストレス曝露による前障神経細胞の活動変化 (2024)
  • Author(s): 横山泰久, 田沼将人, 大久保仁, 宮司渓汰, 勢力薫, 野村洋, 橋本均, 笠井淳司
  • Organizer: 日本薬学会第144年会
• [Presentation] 自閉スペクトラム症モデルPOGZ変異マウスの前帯状皮質領域に着目した社会性行動異常に関する病態解析 (2024)
  • Author(s): 北川航平, 竹本智哉, 勢力薫, 笠井淳司, 橋本均, 中澤敬信
  • Organizer: 日本薬学会第144年会
• [Presentation] 自閉スペクトラム症モデルマウスの痛覚異常と社会性行動障害におけるTRPV1の役割 (2024)
  • Author(s): 田原孟, 今戸瑛二, 歌大介, 川瀬啓生, 樋口桃子, 山川英訓, 小川公一, 浅野智志, 田熊一敞, 橋本均, 久米利明, 古武弥一郎, 吾郷由希夫
  • Organizer: 日本薬学会第144年会
• [Presentation] 2p16.3領域欠失変異を有する自閉スペクトラム症患者のiPS細胞由来分化神経系細胞の機能解析 (2024)
  • Author(s): 片山沙香, 河野翔太郎, 鮎澤有希子, 大友愛佳, 三浦大樹, 福島穂高, 橋本亮太, 橋本均, 中澤敬信
  • Organizer: 日本薬学会第144年会
• [Presentation] 環境エンリッチメントによる3q29領域欠失導入マウスの精神疾患様行動の回復 (2024)
  • Author(s): 秋本祐弥, 福島穂高, 三浦大樹, 橋本均, 橋本亮太, 中澤敬信
  • Organizer: 日本農芸化学会2024年度大会
• [Presentation] 幻覚薬DOIを用いたマウス大脳皮質におけるメゾスケールのカルシウムイメージング (2024)
  • Author(s): 新谷勇介, 中井信裕, 早田敦子, 橋本均, 内匠透
  • Organizer: 第144回日本薬理学会近畿部会
• [Presentation] 白色脂肪組織量制御におけるミトコンドリア蛋白質p13の役割 (2023)
  • Author(s): 野口雅史, 原さとみ, 岩田圭子, 橋本均, 新谷紀人
  • Organizer: 第97回日本薬理学会年会
• [Presentation] 注意欠如・多動症(ADHD)様行動を示すマウスにおいてみられた神経軸索起始部の異常はADHD治療薬によって行動異常の回復と共に回復する (2023)
  • Author(s): 岩橋美咲, 吉村武, 張替若菜, 田熊一敞, 橋本均, 片山泰, 早田敦子
  • Organizer: 第97回日本薬理学会年会
• [Presentation] 非定型抗精神病薬クロザピンの認知機能障害改善作用における結合組織成長因子の関与 (2023)
  • Author(s): 金子皓, 宮岡辰典, 山内良介, 竹内修斗, 河内琢也, 陳露, 片平海雅, 石本憲司, 樋野展正, 早田敦子, 中澤敬信, 田熊一敞, 中川晋作, 橋本均, 吾郷由希夫
  • Organizer: 第97回日本薬理学会年会
• [Presentation] 内側前頭前皮質におけるPACAP-PAC1シグナルの遮断が反復社会的敗北ストレスマウスに与える影響 (2023)
  • Author(s): 竹下黎, 早田敦子, 豊田博紀, 新谷勇介, 生田学登, 高崎一朗, 栗原崇, 田熊一敞, 加藤隆史, 橋本均
  • Organizer: 第97回日本薬理学会年会
• [Presentation] 細胞種特異的プロモーター搭載型AAVベクターにおける、特異性と標識効率の至適化方法の確立 (2023)
  • Author(s): 児嶋励央, 勢力薫, 六城宏紀, 笠井淳司, 中澤敬信, 橋本均
  • Organizer: 第97回日本薬理学会年会
• [Presentation] 非定型抗精神病薬クロザピンの作用機序に関与する神経活動変化の解明 (2023)
  • Author(s): 平戸祐充, 勢力薫, 山田翔平, 児嶋励央, 笠井淳司, 中澤敬信, 橋本均
  • Organizer: 第97回日本薬理学会年会
• [Presentation] 患者iPS細胞由来分化神経細胞を用いた自閉スペクトラム症関連遺伝子POGZの機能解析 (2023)
  • Author(s): 鮎澤有希子, 河野翔太郎, 大友愛佳, 片山沙香, 濱田萌々子, 福島穂高, 三浦大樹, 橋本均, 橋本亮太, 中澤敬信
  • Organizer: 第97回日本薬理学会年会
• [Presentation] 神経ペプチド受容体VIPR2遺伝子のコピー数変異モデルマウスは超音波発声の変化と社会性行動の低下を示す (2023)
  • Author(s): 片平海雅, 陳露, 宮岡辰典, 北川航平, 竹内修斗, 山田めゐ, 金子皓, 石本憲司, 樋野展正, 中澤敬信, 橋本均, 中川晋作, 吾郷由希夫
  • Organizer: 第97回日本薬理学会年会
• [Presentation] 脳疾患の病態解析へ向けた脳イメージングとシステム薬理学 (2023)
  • Author(s): 橋本均
  • Organizer: 第97回日本薬理学会年会
• [Presentation] 脳-脊髄トップダウンシグナルが神経障害性アロディニアに及ぼす影響の網羅的解析 (2023)
  • Author(s): 藤森一樹, 齊藤秀俊, 勢力薫, 橋本均, 津田誠
  • Organizer: 第97回日本薬理学会年会
• [Presentation] 注意欠如・多動症様行動を示すPACAP欠損マウスは神経軸索起始部の異常を呈し、その異常は行動異常と共にアトモキセチンにより改善する (2023)
  • Author(s): 岩橋美咲, 吉村武, 張替若菜, 田熊一敞, 橋本均, 片山泰, 早田敦子
  • Organizer: 第33回神経行動薬理 若手研究者の集い
• [Presentation] 胎生期PGD2-DP1シグナル活性化はマウスの自閉症様の精神行動異常を引き起こす (2023)
  • Author(s): 村田拳一朗, 早田敦子, 菊池泰河, 岩崎美咲, 毛利育子, 橘雅弥, 田熊一敞, 片山泰一, 谷池雅子, 橋本均
  • Organizer: 第50回日本脳科学会
• [Presentation] 高スケーラブルイメージング技術を用いた脳の理解と疾患病態の解明 (2023)
  • Author(s): 橋本均
  • Organizer: 第251回 原医研セミナー
  • Invited
• [Presentation] Development of an AAV vector for noradrenergic neuron-specific gene expression and application to mesoscale analysis of noradrenergic wiring diagrams in mice. (2023)
  • Author(s): Kaoru Seiriki, Shunsuke Maeda, Leo Kojima, Atsushi Kasai, Hitoshi Hashimoto
  • Organizer: Neuroscience 2023
  • Int'l Joint Research
• [Presentation] (R)-ketamine enhances anterior insular cortex activity associated with social cognition. (2023)
  • Author(s): Rei Yokoyama, Yukio Ago, Masato Tanuma, Yuto Shimazaki, Kaoru Seiriki, Takanobu Nakazawa, Kenji Hashimoto, Atsushi Kasai, Hitoshi Hashimoto
  • Organizer: Neuroscience 2023
  • Int'l Joint Research
• [Presentation] Network centralities of prefrontal and somatosensory cortices are decreased in a mouse model of developmental disorders (2023)
  • Author(s): Hiroki Ueno, Yusuke Iyanaga, Yuta Hara, Jin Ohkubo, Yuka Nakai, Kaoru Seiriki, Shun Yamaguchi, Yukio Ago, Kazuhiro Takuma, Hitoshi Hashimoto, Atsushi Kasai
  • Organizer: Neuroscience 2023
  • Int'l Joint Research
• [Presentation] Activation of the claustrum ensemble increases anxiety levels following stress exposure (2023)
  • Author(s): Masato Tanuma, Yoshihisa Yokoyama, Keita Miyaji, Jin Ohkubo, Rei Yokoyama, Hiroki Ueno, Kaoru Seiriki, Hiroshi Nomura, Hitoshi Hashimoto, Atsushi Kasai
  • Organizer: Neuroscience 2023
  • Int'l Joint Research
• [Presentation] Autism-associated ANK2 regulates development of cortical neurons (2023)
  • Author(s): Shotaro Kawano, Masayuki Baba, Hotaka Fukushima, Daiki Miura, Hitoshi Hashimoto, Takanobu Nakazawa
  • Organizer: Neuroscience 2023
  • Int'l Joint Research
• [Presentation] Oxytocin restores abnormal social behavior in a mouse model of 3q29 microdeletion. (2023)
  • Author(s): Tomoya Takemoto, Kohei Kitagawa, Kazuki Nagayasu, Kaoru Seiriki, Atsuko Hayata-Takano, Atsushi Kasai, Yukio Ago, Kazuhiro Takuma, Daisuke Mori, Norio Ozaki, Ryota Hashimoto, Hitoshi Hashimoto, Takanobu Nakazawa
  • Organizer: Neuroscience 2023
  • Int'l Joint Research
• [Presentation] 全脳イメージング技術を用いた精神疾患の病態解析 (2023)
  • Author(s): 橋本均
  • Organizer: 第42回躁うつ病の薬理・生化学的研究懇話会
  • Invited
• [Presentation] Volumetric trans-scale imaging of massive quantity of heterogeneous cell populations in centimeter-wide tissue and embryo (2023)
  • Author(s): Takeharu Nagai, Taro Ichimura, Taishi Kakizuka, Yuki Sato, Keiko Itano, Kaoru Seiriki, Hitoshi Hashimoto, Hiroya Itoga, Shuichi Onami
  • Organizer: Cold Spring Harbor Asia／Advances in Optical Interrogation of Living Cells and Organisms: Focus on the Brain
  • Int'l Joint Research / Invited
• [Presentation] 精神疾患モデルの全のイメージングによる病態研究 (2023)
  • Author(s): 橋本均
  • Organizer: 国立精神・神経医療研究センター 精神病態セミナー
  • Invited
• [Presentation] Overexpression of VPAC2 receptors in the embryonic mouse central nervous system causes brain atrophy, increased white matter, and impaired sensorimotor gating (2023)
  • Author(s): Yukio Ago, Allan J. MacKenzie-Graham, Hitoshi Hashimoto, James A. Waschek
  • Organizer: AsCNP2023
  • Int'l Joint Research
• [Presentation] Trans scale scope for volumetric imaging of micrometer scale cellular dynamics in centimeter scale multicellular systems (2023)
  • Author(s): Taro Ichimura, Taishi Kakizuka, Keiko Itano, Kaoru Seiriki, Hitoshi Hashimoto, Yuki Sato, and Takeharu Nagai
  • Organizer: IMC20（20th International Microscopy Congress)
  • Int'l Joint Research
• [Presentation] ストレス誘発性不安応答を制御する前障神経細胞の遺伝子プロファイル (2023)
  • Author(s): 大久保仁, 田沼将人, 横山泰久, 中井悠花, 島崎雄人, 植野寛貴, 橋本均, 笠井淳司
  • Organizer: 次世代を担う若手のための創薬・医療薬理シンポジウム
• [Presentation] アストロサイトの多様性と形態の分子的基盤およびアルツハイマー病との関連 (2023)
  • Author(s): 遠藤史人, 笠井 淳司, Gradinaru Viviana, 橋本均, 河口力, Baljit S Khakh
  • Organizer: 第46回日本神経科学大会
• [Presentation] 精神疾患の基礎臨床連携研究 (2023)
  • Author(s): 中澤敬信, 橋本均, 橋本亮太
  • Organizer: 第46回日本神経科学大会
• [Presentation] Unbiased approach to studying the brain and its disorders using a whole-brain imaging technique:Claustrum mediates stress-induced anxiety responses and stress resistance (2023)
  • Author(s): 橋本均
  • Organizer: 第9回中日薬理学・臨床薬理学ジョイントミーティング
  • Int'l Joint Research
• [Presentation] 深層学習を用いた発達障害モデルマウスの社会性行動障害に関わる機能的ネットワークの同定 (2023)
  • Author(s): 植野寛貴, 彌永祐輔, 原雄大, 大久保仁, 中井悠花, 勢力薫, 山口瞬, 吾郷由希夫, 田熊一敞, 橋本均 , 笠井 淳司
  • Organizer: 第66回日本神経化学大会
• [Presentation] 前障ストレス応答性神経細胞のマーカー遺伝子の同定 (2023)
  • Author(s): 大久保仁, 田沼将人, 横山泰久, 橋本均, 笠井淳司
  • Organizer: 第66回日本神経化学大会
• [Presentation] 胎生期中枢神経系におけるVPAC2受容体の過剰発現は脳の萎縮と白質の増加、感覚情報処理機能の障害を引き起こす (2023)
  • Author(s): 吾郷由希夫, Allan J. MacKenzie-Graham, 橋本均, James A. Waschek
  • Organizer: 第143回日本薬理学会近畿部会
• [Presentation] コカイン条件付け場所嗜好性試験における脳内機能的神経ネットワークの解析 (2023)
  • Author(s): 島﨑雄人, 横山玲, 植野寛貴, 大久保仁, 中井悠花, 横山泰久, 村重哲史, 国田勝行, 吉本潤一郎, 勢力薫, 永井拓, 橋本均, 笠井 淳司
  • Organizer: 第143回日本薬理学会近畿部会
• [Presentation] 血管作動性腸管ペプチド受容体2シグナルはERK経路を介した乳癌細胞増殖に関与している (2023)
  • Author(s): 浅野智志, 小野亜美, 坂元孝太郎, 早田敦子, 中澤敬信, 谷本幸太郎, 橋本均, 吾郷由希夫
  • Organizer: 第143回日本薬理学会近畿部会
• [Presentation] ヒト染色体3q29領域欠失を導入した自閉スペクトラム症モデルマウスの社会行動異常はオキシトシンの投与により回復する (2023)
  • Author(s): 竹本智哉, 馬場優志, 北川航平, 永安一樹, 勢力薫, 早田敦子, 笠井淳司, 吾郷由希夫, 田熊一敞, 橋本亮太,橋本均, 中澤敬信
  • Organizer: 第143回日本薬学会年会
• [Presentation] 誕生日タグづけ法を用いた胎仔期バルプロ酸暴露による大脳皮質細胞分布異常の全脳解析 (2023)
  • Author(s): 瀬尾慧, 笠井淳司, 植野寛貴, 中井悠花, 島崎雄人, 田沼将人, 馬場優志, 吉永怜史, 大久保仁, 勢力薫, 田熊一敞, 久保健一郎, 橋本均
  • Organizer: 第143回日本薬学会年会
• [Presentation] オキシトシン神経に選択的な遺伝子発現を可能にするAAVベクターの構築 (2023)
  • Author(s): 児嶋励央, 勢力薫, 六城宏紀, 笠井淳司, 橋本均
  • Organizer: 第143回日本薬学会年会
• [Presentation] 不安関連行動を制御する新たな神経回路 (2023)
  • Author(s): 笠井淳司
  • Organizer: 第128回日本解剖学会総会・全国学術集会
  • Invited
• [Presentation] Brain-wide neuronal activation mapping shed light on new ensembles controlling brain functions (2023)
  • Author(s): Atsushi Kasai
  • Organizer: 日本生理学会第100回記念大会
• [Presentation] Brain-wide activation mapping highlights new neuronal ensembles in emotional control (2023)
  • Author(s): Atsushi Kasai
  • Organizer: 第14回日本安全性薬理研究会
  • Invited
• [Presentation] Neuronal activity of claustral populations is altered by exposure to stress (2023)
  • Author(s): Atsushi Kasai, Masato Tanuma, Jin Ohkubo, Yoshihisa Yokoyama, Hashimoto Hitoshi
  • Organizer: 3rd International Symposium on Brain Information Dynamics 2023
  • Int'l Joint Research
• [Presentation] Increased neuronal activity of claustral populations in stress-induced behavioral changes (2023)
  • Author(s): Masato Tanuma, Jin Ohkubo, Yoshihisa Yokoyama, Hitoshi Hashimoto, Atsushi Kasai
  • Organizer: 3rd International Symposium on Brain Information Dynamics 2023
  • Int'l Joint Research
• [Presentation] Claustrum mediates stress-induced anxiety responses and stress resistance (2022)
  • Author(s): Hitoshi Hashimoto, Misaki Niu, Masato Tanuma, Kaoru Seiriki, Yukio Ago, Shun Yamaguchi, Atsushi Kasai
  • Organizer: ACNP2022
  • Int'l Joint Research
• [Presentation] Activation of the Rostral Agranular Insular Cortex is Involved in the Antidepressant Actions of Arketamine (2022)
  • Author(s): Yukio Ago, Rei Yokoyama, Atsushi Kasai, Masato Tanuma, Misuzu Hayashida, Yuto Shimazaki, Momoko Higuchi, Hisato Igarashi, Kaoru Seiriki, Shun Yamaguchi, Takanobu Nakazawa, Kenji Hashimoto, Hitoshi Hashimoto
  • Organizer: ACNP2022
  • Int'l Joint Research
• [Presentation] アールケタミンの抗うつ作用発現には島皮質が関与する (2022)
  • Author(s): 横山玲, 吾郷由希夫, 笠井淳司, 田沼将人, 林田美鈴, 島﨑雄人, 樋口桃子, 五十嵐久人, 勢力薫, 山口瞬, 中澤敬信, 橋本謙二, 橋本均
  • Organizer: 第96回日本薬理学会年会
• [Presentation] ストレス誘発不安応答を制御する前障神経細胞の in vivo カルシウムイメージング (2022)
  • Author(s): Masato Tanuma, Keita Miyaji, Jin Ohkubo, Hiroshi Nomura, Masabumi Minami, Hitoshi Hashimoto, Atsushi Kasai
  • Organizer: 第96回日本薬理学会年会
• [Presentation] Neuronal activity of claustral populations during anxiety-related behaviors is altered by exposure to stress (2022)
  • Author(s): Rei Yokoyama, Yukio Ago, Atsushi Kasai, Masato Tanuma, Misuzu Hayashida, Yuto Shimazaki, Momoko Higuchi, Hisato Igarashi, Kaoru Seiriki, Shun Yamaguchi, Takanobu Nakazawa, Kenji Hashimoto, Hitoshi Hashimoto
  • Organizer: Neuroscience 2022
  • Int'l Joint Research
• [Presentation] Intranasal oxytocin administration suppresses social contact-induced neural activity in a POGZ-Q1038R mutant mouse model of autism spectrum disorder (2022)
  • Author(s): Kohei Kitagawa, Masayuki Baba, Tomoya Takemoto, Masato Tanuma, Misuzu Hayashida, Shun Yamaguchi, Yukio Ago, Kaoru Seiriki, Atsuko Hayata-Takano, Kazuhiro Takuma, Atsushi Kasai, Hitoshi Hashimoto, Takanobu Nakazawa
  • Organizer: Neuroscience 2022
  • Int'l Joint Research
• [Presentation] Claustral neural circuits involved in the control of stress-induced anxiety responses (2022)
  • Author(s): Atsushi Kasai
  • Organizer: Neuroscience 2022
  • Int'l Joint Research
• [Presentation] Fast and lasting antidepressant-like effect of small molecule PACAP receptor PAC1 antagonist (2022)
  • Author(s): Yusuke Shintani, Atsuko Hayata-Takano, Yui Yamano, Manato Ikuta, Rei Takeshita, Kenichiro Murata, Ichiro Takasaki, Takashi Kurihara, Hitoshi Hashimoto
  • Organizer: VPAC ISBAP 2022
  • Int'l Joint Research
• [Presentation] The VIP/VIPR2 pathway regulates breast cancer cell migration (2022)
  • Author(s): Satoshi Asano, Misa Yamasaka, Kairi Ozasa, Kotaro Sakamoto, Atsuko Hayata-Takano, Takanobu Nakazawa, Hitoshi Hashimoto, James A. Waschek, Yukio Ago
  • Organizer: VPAC ISBAP 2022
  • Int'l Joint Research
• [Presentation] Social defeat stress induces activation of PACAP-expressing neurons in thermoregulatory systems (2022)
  • Author(s): Yuzuka Fujimoto, Kaoru Seiriki, Shunsuke Maeda, Taiyou Baba, Atsuko Hayata-Takano, Atsushi Kasai, Hitoshi Hashimoto
  • Organizer: VPAC ISBAP 2022
  • Int'l Joint Research
• [Presentation] Effect of pituitary adenylate cyclase-activating polypeptide (PACAP) on heat-stress (2022)
  • Author(s): Keisuke Suzuki, Hiroki Yamaga, Hirokazu Ohtaki, Satoshi Hirako, Kazuyuki Miyamoto, Motoyasu Nakamura, Kaoru Yanagisawa, Takuya Shimada, Tomohiko Hosono, Hitoshi Hashimoto, Kazuho Honda, Kenji Dohi
  • Organizer: VPAC ISBAP 2022
  • Int'l Joint Research
• [Presentation] Neuron-specific overexpression of human VPAC2 receptors in mice causes cognitive dysfunction (2022)
  • Author(s): Ami Ono, Daichi Koan, Satoshi Asano, Tatsunori Miyaoka, Lu Chen, Mei Yamada, Shinsaku Nakagawa, Atsuko Hayata-Takano, Takanobu Nakazawa, Akihiro Harada, Hitoshi Hashimoto, James A. Waschek, Yukio Ago
  • Organizer: VPAC ISBAP 2022
  • Int'l Joint Research
• [Presentation] Impaired neurodevelopment in iPS cell-derived neural stem cells from psychiatric patients with 7q36.3 microduplication (2022)
  • Author(s): Kohei Kitagawa, Masayuki Baba, Tomoya Takemoto, Kazuki Nagayasu, Atsushi Kasai, Kazuhiro Takuma, Ryota Hashimoto, Hitoshi Hashimoto, Yukio Ago, Takanobu Nakazawa
  • Organizer: VPAC ISBAP 2022
  • Int'l Joint Research
• [Presentation] A single oral administration of small-molecule PAC1 antagonist attenuates repeated stress-induced depressive-like behaviors in mice (2022)
  • Author(s): Manato Ikuta, Atsuko Hayata-Takano, Yusuke Shintani, Yui Yamano, Rei Takeshita, Kenichiro Murata, Ichiro Takasaki, Takashi Kurihara, Hitoshi Hashimoto
  • Organizer: VPAC ISBAP 2022
  • Int'l Joint Research
• [Presentation] Chemogenetic inhibition of PACAP neurons projecting to the mPFC exerts antidepressant-like effects (2022)
  • Author(s): Yui Yamano, Atsuko Hayata-Takano, Yusuke Shintani, Manato Ikuta, Rei Takeshita1, Kenichiro Murata1, Hitoshi Hashimoto
  • Organizer: VPAC ISBAP 2022
  • Int'l Joint Research
• [Presentation] Regulation of feeding behavior via neuropeptide network by PACAP in the ventral medial hypothalamus (2022)
  • Author(s): Yuki Kambe, Trung Thanh Nguyen, Thi Thu Nguyen, Norihito Shintani, Hitoshi Hashimoto, Takashi Kurihara, Atsuro Miyata
  • Organizer: VPAC ISBAP 2022
  • Int'l Joint Research
• [Presentation] 自閉スペクトラム症モデルマウスを用いた社会性行動障害に関わる機能的神経ネットワークの同定 (2022)
  • Author(s): 植野寛貴, 笠井淳司, 彌永祐輔, 原雄大, 大久保仁, 中井 悠花, 勢力薫, 山口瞬, 吾郷由希夫, 田熊一敞, 橋本均
  • Organizer: 第72回日本薬学会関西支部総会
• [Presentation] 視床下部腹内側核PACAPによるニューロペプチドネットワークを介した摂食行動の制御 (2022)
  • Author(s): 神戸悠輝, Trung Thanh Nguyen, 新谷紀人, 橋本均, 栗原崇, 宮田篤郎
  • Organizer: 第75回日本薬理学会西南部会
• [Presentation] 光と機械学習で紐解く、恐怖記憶コード神経回路の動的生成過程と情報処理 (2022)
  • Author(s): 揚妻正和, 佐藤一誠, 田中康裕, Luis Carrillo-Reid, illo-Reid, 笠井敦司, 新井由之, 吉友美樹, 稲垣貴士, 橋本均, 鍋倉淳一, 永井健治
  • Organizer: 第31回バイオイメージング学会
• [Presentation] ミトコンドリア蛋白質p13の呼吸器組織における役割 (2022)
  • Author(s): 野口雅史, 原さとみ, 岩田圭子, 橋本均, 新谷紀人
  • Organizer: 生体機能と創薬シンポジウム2022
• [Presentation] 全脳イメージングシステムFASTの開発と精神・神経疾患研究への応用 (2022)
  • Author(s): 笠井淳司
  • Organizer: 生体機能と創薬シンポジウム2022
  • Invited
• [Presentation] マルチスケール解析による精神疾患の創薬標的探索 (2022)
  • Author(s): 笠井淳司
  • Organizer: 第37回創薬セミナー
  • Invited
• [Presentation] 視床下部における腹内側核PACAPから背内側核ガラニンへの神経ペプチドシグナルによる摂食制御機構の解明 (2022)
  • Author(s): 神戸悠輝, Trung Thanh Nguyen, 新谷紀人, 橋本均, 栗原崇, 宮田篤郎
  • Organizer: Neuro2022
  • Int'l Joint Research
• [Presentation] The mechanisms of stress-induced anxiety responses by brain-wide neuronal activation mapping (2022)
  • Author(s): Atsushi Kasai
  • Organizer: Neuro2022
  • Int'l Joint Research / Invited
• [Presentation] ノルアドレナリン作動性神経選択的AAVベクターの構築と社会性ストレスにより活動する細胞の軸索分布解析 (2022)
  • Author(s): 勢力薫, 前田駿介, 藤本柚香, 山田翔平, 平戸祐充, 笠井淳司, 橋本均
  • Organizer: Neuro2022
  • Int'l Joint Research
• [Presentation] 不安様行動時における前障神経細胞のカルシウムイメージング (2022)
  • Author(s): 田沼将人, 笠井淳司, 宮司渓汰, 大久保仁, 橋本均
  • Organizer: Neuro2022
  • Int'l Joint Research
• [Presentation] レオウイルスの前投与によるPEG修飾リポソームの腫瘍集積の向上に関する検討 (2022)
  • Author(s): 櫻井文教, 江口真帆, 平田聖也, 石神育歩, 田沼将人, 笠井淳司, 橋本均, 細川美香, 大河原賢一, 水口裕之
  • Organizer: 第38回日本DDS学会学術集会
• [Presentation] Altered neuronal activity of the claustrum by stress exposure (2022)
  • Author(s): Masato Tanuma, Keita Miyaji, Jin Ohkubo, Hiroshi Nomura, Hitoshi Hashimoto, Atsushi Kasai
  • Organizer: MCCS-Asia第2回国際シンポジウム
  • Int'l Joint Research
• [Presentation] Claustral ensemble for stress-induced anxiety responses (2022)
  • Author(s): Atsushi Kasai, Misaki Niu, Masato Tanuma, Kaoru Seiriki, Hitoshi Hashimoto
  • Organizer: MCCS-Asia第2回国際シンポジウム
  • Int'l Joint Research
• [Presentation] Calcium imaging of claustral neurons during anxiety-like behaviors (2022)
  • Author(s): 田沼将人, 宮司渓汰, 大久保仁, 勢力薫, 野村洋, 橋本均, 笠井淳司
  • Organizer: Cell Press
  • Int'l Joint Research
• [Presentation] Claustrum mediates stress-induced anxiety responses and stress resistance (2022)
  • Author(s): Atsushi Kasai, Misaki Niu, Masato Tanuma, Kaoru Seiriki, Hitoshi Hashimoto
  • Organizer: Cell Press
  • Int'l Joint Research