| Budget Amount *help |
¥45,240,000 (Direct Cost: ¥34,800,000、Indirect Cost: ¥10,440,000)
Fiscal Year 2022: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
Fiscal Year 2021: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
Fiscal Year 2020: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
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| Outline of Final Research Achievements |
In Drosophila epithelium, cells mutant for apicobasal polarity genes overproliferate and develop into tumors but are eliminated via cell competition when surrounded by wild-type cells. We have previously found that these oncogenic mutant clones surrounded by wild-type cells cause tumorigenesis by abrogating cell competition when circulating insulin peptide is elevated (hyperinsulinemia) in the fly body. In this study, we tried to dissect the mechanism by which insulin signaling regulates cell competition.
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