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Spiral progression of DNA damage repair, epigenetic alterations and metabolic changes in metabolic kidney diseases

Research Project

Project/Area Number 20H00535
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Review Section Medium-sized Section 53:Organ-based internal medicine and related fields
Research InstitutionKeio University

Principal Investigator

ITOH Hiroshi  慶應義塾大学, 医学部(信濃町), 教授 (40252457)

Co-Investigator(Kenkyū-buntansha) 林 香  慶應義塾大学, 医学部(信濃町), 講師 (60445294)
神田 武志  慶應義塾大学, 医学部(信濃町), 講師 (80317114)
長谷川 一宏  慶應義塾大学, 医学部(信濃町), 特任講師 (30424162)
脇野 修  慶應義塾大学, 医学部(信濃町), 准教授 (50265823)
徳山 博文  慶應義塾大学, 医学部(信濃町), 講師 (50276250)
Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥45,630,000 (Direct Cost: ¥35,100,000、Indirect Cost: ¥10,530,000)
Fiscal Year 2022: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2021: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2020: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Keywordsエピゲノム / DNA損傷 / ニコチン酸代謝 / 慢性腎臓病 / DNA損傷修復 / NAD代謝 / 代謝腎臓病 / エピゲノム変化
Outline of Research at the Start

申請者がこれまで提唱してきたMetabolic Kidney Disease(MKD、代謝腎臓病)の概念に基づき、本研究においてはMKDにおけるエネルギー代謝障害の作用点としてDNA損傷修復環境に焦点を当てる。MKDにおいては全身および腎臓内のエネルギー代謝変容と、腎臓の構造機能の維持に伴うDNA損傷とその修復および随伴して惹起されるエピゲノム変調が、双方向的に関与し合いMKDの進展をもたらす可能性を想起した。従って本研究においては、代謝変容の腎臓DNA損傷修復・エピゲノム変調への関わり、腎臓DNA損傷修復環境に依存したエピゲノム変化の代謝制御への関わりを明らかにする。

Outline of Final Research Achievements

We have elucidated the mechanism of metabolic kidney disease, namely chronic kidney disease associated with metabolic disorders, including diabetes, dyslipidemia and obesity, focusing on the organ-organ associations. This study aimed to investigate pathophysiology of the disorders, introducing the new viewpoint, DNA damage response (DDR). As a result, DDR in the kidney causes metabolic alterations, and metabolic disorders also cause DDR alteration, which drives progression of CKD.

Academic Significance and Societal Importance of the Research Achievements

高齢化社会において増加する高血圧、糖尿病を背景に、慢性腎臓病は増加傾向にあり、代謝腎臓病の新たな治療戦略の開発は喫緊の課題である。本研究は、慢性腎臓病におけるDNA損傷とそれに伴って惹起されるエピゲノム変化が、代謝変化と双方向性に関与し合い、病態の進展をもたらすという新しいコンセプトを提案したものであり、学術的に新規性・独創性が高い。また、新規治療標的の候補分子を複数提案しており、疾患人口が増加する中で、社会的意義も大きいと考える。

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Comments on the Screening Results   Annual Research Report
  • Research Products

    (37 results)

All 2023 2022 2021 2020

All Journal Article (37 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 37 results,  Open Access: 23 results)

  • [Journal Article] Canagliflozin protects the cardiovascular system through effects on the gut environment in non-diabetic nephrectomized rats2023

    • Author(s)
      Matsui Ayumi、Yoshifuji Ayumi、Irie Junichiro、Tajima Takaya、Uchiyama Kiyotaka、Itoh Tomoaki、Wakino Shu、Itoh Hiroshi
    • Journal Title

      Clinical and Experimental Nephrology

      Volume: 27 Issue: 4 Pages: 295-308

    • DOI

      10.1007/s10157-022-02312-y

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Significance of podocyte DNA damage and glomerular DNA methylation in CKD patients with proteinuria2023

    • Author(s)
      Yoshimoto Norifumi、Hayashi Kaori、Hishikawa Akihito、Hashiguchi Akinori、Nakamichi Ran、Sugita-Nishimura Erina、Yoshida-Hama Eriko、Azegami Tatsuhiko、Nakayama Takashin、Itoh Hiroshi
    • Journal Title

      Hypertension Research

      Volume: 46 Issue: 4 Pages: 1000-1008

    • DOI

      10.1038/s41440-023-01169-2

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] NAD+ and mtRNA sensing drive human kidney diseases2023

    • Author(s)
      Itoh Hiroshi、Yoshino Jun
    • Journal Title

      Nature Metabolism

      Volume: 5 Issue: 3 Pages: 357-359

    • DOI

      10.1038/s42255-023-00762-6

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] “Endocrine Supremacism” of new version in the Anthropocene2023

    • Author(s)
      Itoh Hiroshi
    • Journal Title

      Endocrine Journal

      Volume: 70 Issue: 3 Pages: 233-240

    • DOI

      10.1507/endocrj.EJ20221130

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DNA-damaged podocyte-CD8 T cell crosstalk exacerbates kidney injury by altering DNA methylation2023

    • Author(s)
      Nakamichi Ran、Hishikawa Akihito、Chikuma Shunsuke、Yoshimura Akihiko、Sasaki Takashi、Hashiguchi Akinori、Abe Takaya、Tokuhara Tomoko、Yoshimoto Norifumi、Nishimura Erina Sugita、Hama Eriko Yoshida、Azegami Tatsuhiko、Nakayama Takashin、Hayashi Kaori、Itoh Hiroshi
    • Journal Title

      Cell Reports

      Volume: 42 Issue: 5 Pages: 112427-112427

    • DOI

      10.1016/j.celrep.2023.112427

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Correction: Mechanisms of mineralocorticoid receptor-associated hypertension in diabetes mellitus: the role of O-GlcNAc modification2023

    • Author(s)
      Jo Rie、Shibata Hirotaka、Kurihara Isao、Yokota Kenichi、Kobayashi Sakiko、Murai-Takeda Ayano、Mitsuishi Yuko、Hayashi Takeshi、Nakamura Toshifumi、Itoh Hiroshi
    • Journal Title

      Hypertension Research

      Volume: 46 Issue: 3 Pages: 814-814

    • DOI

      10.1038/s41440-023-01167-4

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sodium benzoate attenuates 2,8-dihydroxyadenine nephropathy by inhibiting monocyte/macrophage TNF-α expression2023

    • Author(s)
      Yoichi Oshima, Shu Wakino, Takeshi Kanda, Takaya Tajima, Tomoaki Itoh, Kiyotaka Uchiyama, Keiko Yoshimoto, Jumpei Sasabe, Masato Yasui, Hiroshi Itoh
    • Journal Title

      Sci Rep

      Volume: 13 Issue: 1 Pages: 3331-3331

    • DOI

      10.1038/s41598-023-30056-6

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Plasminogen activator inhibitor 1 is not a major causative factor for exacerbation in a mouse model of SARS-CoV-2 infection2023

    • Author(s)
      Nakayama Takashin、Azegami Tatsuhiko、Kiso Maki、Imai Masaki、Uraki Ryuta、Hayashi Kaori、Hishikawa Akihito、Yoshimoto Norifumi、Nakamichi Ran、Sugita-Nishimura Erina、Yoshida-Hama Eriko、Kawaoka Yoshihiro、Itoh Hiroshi
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1 Pages: 3103-3103

    • DOI

      10.1038/s41598-023-30305-8

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The significance of NAD + metabolites and nicotinamide N-methyltransferase in chronic kidney disease2022

    • Author(s)
      Takahashi R, Kanda T, Komatsu M, Itoh T, Minakuchi H, Urai H, Kuroita T, Shigaki S, Tsukamoto T, Higuchi N, Ikeda M, Yamanaka R, Yoshimura N, Ono T, Yukioka H, Hasegawa K, Tokuyama H, Wakino S, Itoh H.
    • Journal Title

      Sci Rep

      Volume: 12(1) Issue: 1 Pages: 6398-6399

    • DOI

      10.1038/s41598-022-10476-6

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intestinal epithelial NAD(+) biosynthesis regulates GLP-1 production and postprandial glucose metabolism in mice2022

    • Author(s)
      Nagahisa Taichi, Yamaguchi Shintaro, Kosugi Shotaro, Homma Koichiro, Miyashita Kazutoshi, Irie Junichiro, Yoshino Jun, Itoh Hiroshi
    • Journal Title

      Endocrinology

      Volume: 163 Issue: 4 Pages: 1-12

    • DOI

      10.1210/endocr/bqac023

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Home-Based Exercise Program Ameliorates Renal Function Decline in Patients With CKD Stage 4.2022

    • Author(s)
      Adachi K, Uchiyama K, Muraoka K, Nakayama T, Yasuda M, Miyashita K, Tokuyama H, Wakino S, Itoh H.
    • Journal Title

      Kidney Int Rep.

      Volume: 12 Issue: 4 Pages: 809-903

    • DOI

      10.1016/j.ekir.2022.01.006

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lysine-specific demethylase 1 as a corepressor of mineralocorticoid receptor2022

    • Author(s)
      Kohata Nao、Kurihara Isao、Yokota Kenichi、Kobayashi Sakiko、Murai-Takeda Ayano、Mitsuishi Yuko、Nakamura Toshifumi、Morisaki Mitsuha、Kozuma Takahide、Torimitsu Takuto、Kawai Miki、Itoh Hiroshi
    • Journal Title

      Hypertension Research

      Volume: 45 Issue: 4 Pages: 641-649

    • DOI

      10.1038/s41440-022-00859-7

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Vaccination against connective tissue growth factor attenuates the development of renal fibrosis.2022

    • Author(s)
      Nakayama T, Azegami T, Hayashi K, Hishikawa A, Yoshimoto N, Nakamichi R, Sugita E, Itoh H
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 10933-10933

    • DOI

      10.1038/s41598-022-15118-5

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Proximal-tubule molecular relay from early Protein diaphanous homolog 1 to late Rho-associated protein kinase 1 regulates kidney function in obesity-induced kidney damage2022

    • Author(s)
      Ida-Naitoh Makiko、Tokuyama Hirobumi、Futatsugi Koji、Yasuda Marie、Adachi Keika、Kanda Takeshi、Tanabe Yoshiyuki、Wakino Shu、Itoh Hiroshi
    • Journal Title

      Kidney International

      Volume: 102 Issue: 4 Pages: 798-814

    • DOI

      10.1016/j.kint.2022.05.018

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of the intestinal tissue renin-angiotensin system by transient sodium loading in salt-sensitive rats2021

    • Author(s)
      Ryuzaki Masaki、Miyashita Kazutoshi、Sato Masaaki、Inoue Hiroyuki、Fujii Kentaro、Hagiwara Aika、Uto Asuka、Endo Sho、Oshida Takuma、Kinouchi Kenichiro、Itoh Hiroshi
    • Journal Title

      Journal of Hypertension

      Volume: 40 Issue: 1 Pages: 33-45

    • DOI

      10.1097/hjh.0000000000002974

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pre-emptive Short-term Nicotinamide Mononucleotide Treatment in a Mouse Model of Diabetic Nephropathy.2021

    • Author(s)
      Yasuda I, Hasegawa K, Sakamaki Y, Muraoka H, Kawaguchi T, Kusahana E, Ono T, Kanda T, Tokuyama H, Wakino S, Itoh H.
    • Journal Title

      J Am Soc Nephrol

      Volume: 11 Issue: 6 Pages: 1355-1370

    • DOI

      10.1681/asn.2020081188

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DNA repair factor KAT5 prevents ischemic acute kidney injury through glomerular filtration regulation2021

    • Author(s)
      Akihito Hishikawa, Kaori Hayashi (corresponding author), Akiko Kubo, Kazutoshi Miyashita, Akinori Hashiguchi, Kenichiro Kinouchi, Norifumi Yoshimoto, Ran Nakamichi, Riki Akashio, Erina Sugita, Tatsuhiko Azegami, Toshiaki Monkawa, Makoto Suematsu, Hiroshi Itoh.
    • Journal Title

      iScience.

      Volume: 24(12) Issue: 12 Pages: 103436-103436

    • DOI

      10.1016/j.isci.2021.103436

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transient Dexamethasone Loading Induces Prolonged Hyperglycemia in Male Mice With Histone Acetylation in <i>Dpp-4</i> Promoter2021

    • Author(s)
      Uto Asuka、Miyashita Kazutoshi、Endo Sho、Sato Masaaki、Ryuzaki Masaki、Kinouchi Kenichiro、Mitsuishi Masanori、Meguro Shu、Itoh Hiroshi
    • Journal Title

      Endocrinology

      Volume: 162 Issue: 12

    • DOI

      10.1210/endocr/bqab193

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians2021

    • Author(s)
      Yuko Sato, Koji Atarashi, Damian R. Plichta, Yasumichi Arai, Satoshi Sasajima, SM. Kearney, Kozue Takeshita, AN. Skelly, Youxian Li, Takeshi Tanoue, Seiko Narushima, DR. Littman, MA. Fischbach, Y Uwamino, T Inoue, A Honda, Masahira Hattori, Tsuyoshi Murai, Ramnik J. Xavier, Nobuyoshi Hirose, Kenya Honda, et al.
    • Journal Title

      Nature

      Volume: 599 Issue: 7885 Pages: 458-464

    • DOI

      10.1038/s41586-021-03832-5

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Calcium phosphate microcrystals in the renal tubular fluid accelerate chronic kidney disease progression2021

    • Author(s)
      Shiizaki Kazuhiro、Tsubouchi Asako、Miura Yutaka、....Itoh Hiroshi、....Kuro-o Makoto
    • Journal Title

      Journal of Clinical Investigation

      Volume: 131 Issue: 16

    • DOI

      10.1172/jci145693

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Vaccination against receptor for advanced glycation end products attenuates the progression of diabetic kidney disease.2021

    • Author(s)
      Azegami T, Nakayama T, Hayashi K, Hishikawa A, Yoshimoto N, Nakamichi R, Itoh H.
    • Journal Title

      Diabetes.

      Volume: 70(9) Issue: 9 Pages: 2147-2158

    • DOI

      10.2337/db20-1257

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of visit‐to‐visit glycemic variability with risk of cardiovascular diseases in high‐risk Japanese patients with type 2 diabetes: A subanalysis of the EMPATHY trial2021

    • Author(s)
      Sato Midori、Inaishi Jun、Saisho Yoshifumi、Sato Yasunori、Komuro Issei、Itoh Hiroshi
    • Journal Title

      Journal of Diabetes Investigation

      Volume: 12 Issue: 12 Pages: 2190-2196

    • DOI

      10.1111/jdi.13597

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduced beta cell number rather than size is a major contributor to beta cell loss in type 2 diabetes2021

    • Author(s)
      Sasaki Hironobu、Saisho Yoshifumi、Inaishi Jun、Watanabe Yuusuke、Tsuchiya Tami、Makio Masayoshi、Sato Midori、Nishikawa Masaru、Kitago Minoru、Yamada Taketo、Itoh Hiroshi
    • Journal Title

      Diabetologia

      Volume: 64 Issue: 8 Pages: 1816-1821

    • DOI

      10.1007/s00125-021-05467-7

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diabetic condition induces hypertrophy and vacuolization in glomerular parietal epithelial cells2021

    • Author(s)
      Takahisa Kawaguchi, Kazuhiro Hasegawa, Itaru Yasuda, Hirokazu Muraoka, Hiroyuki Umino, Hirobumi Tokuyama, Akinori Hashiguchi, Shu Wakino, Hiroshi Itoh
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1

    • DOI

      10.1038/s41598-021-81027-8

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Importance of Adipose Tissue NAD+ Biology in Regulating Metabolic Flexibility2021

    • Author(s)
      Franczyk Michael P、Qi Nathan、Stromsdorfer Kelly L、Li Chengcheng、Yamaguchi Shintaro、Itoh Hiroshi、Yoshino Mihoko、Sasaki Yo、Brookheart Rita T、Finck Brian N、DeBosch Brian J、Klein Samuel、Yoshino Jun
    • Journal Title

      Endocrinology

      Volume: 162 Issue: 3 Pages: 1-12

    • DOI

      10.1210/endocr/bqab006

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Effects of high glucose and lipotoxicity on diabetic podocytes2021

    • Author(s)
      Ran Nakamichi, Kaori Hayashi, Hiroshi Itoh
    • Journal Title

      Nutrients

      Volume: 13(1) Issue: 1 Pages: 241-241

    • DOI

      10.3390/nu13010241

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] C-C motif chemokine receptor 9 regulates obesity-induced insulin resistance via inflammation of the small intestine in mice2021

    • Author(s)
      Amiya Takeru、Nakamoto Nobuhiro、Irie Junichiro、Taniki Nobuhito、Chu Po-Sung、Koda Yuzo、Miyamoto Kentaro、Yamaguchi Akihiro、Shiba Shunsuke、Morikawa Rei、Itoh Hiroshi、Kanai Takanori
    • Journal Title

      Diabetologia

      Volume: 64 Issue: 3 Pages: 603-617

    • DOI

      10.1007/s00125-020-05349-4

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effect of aldosterone and aldosterone blockade on the progression of chronic kidney disease: a randomized placebo-controlled clinical trial2020

    • Author(s)
      Minakuchi Hitoshi、Wakino Shu、Urai Hidenori、Kurokochi Arata、Hasegawa Kazuhiro、Kanda Takeshi、Tokuyama Hirobumi、Itoh Hiroshi
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1

    • DOI

      10.1038/s41598-020-73638-4

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Asperuloside Improves Obesity and Type 2 Diabetes through Modulation of Gut Microbiota and Metabolic Signaling2020

    • Author(s)
      Nakamura Anna、Yokoyama Yoko、Tanaka Kazuki、Benegiamo Giorgia、Hirayama Akiyoshi、Zhu Qi、Kitamura Naho、Sugizaki Taichi、Morimoto Kohkichi、Itoh Hiroshi、Fukuda Shinji、Auwerx Johan、Tsubota Kazuo、Watanabe Mitsuhiro
    • Journal Title

      iScience

      Volume: 23 Issue: 9 Pages: 101522-101522

    • DOI

      10.1016/j.isci.2020.101522

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Contribution of uremic dysbiosis to insulin resistance and sarcopenia.2020

    • Author(s)
      Uchiyama K, Wakino S, Irie J, Miyamoto J, Matsui A, Tajima T, Itoh T, Oshima Y, Yoshifuji A, Kimura I, Itoh H.
    • Journal Title

      Nephrol Dial Transplant.

      Volume: 35 Issue: 9 Pages: 1501-1517

    • DOI

      10.1093/ndt/gfaa076

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Low birth weight trends: possible impacts on the prevalences of hypertension and chronic kidney disease2020

    • Author(s)
      Kanda Takeshi、Murai-Takeda Ayano、Kawabe Hiroshi、Itoh Hiroshi
    • Journal Title

      Hypertension Research

      Volume: 43 Issue: 9 Pages: 859-868

    • DOI

      10.1038/s41440-020-0451-z

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Maternal gut microbiota in pregnancy influences offspring metabolic phenotype in mice2020

    • Author(s)
      Kimura I, Miyamoto J, Ohue-Kitano R, Watanabe K, Yamada T, Onuki M, Aoki R, Isobe Y, Kashihara D, Inoue D, Inaba A, Takamura Y, Taira S, Kumaki S, Watanabe M, Ito M, Nakagawa F, Irie J, Kakuta H, Shinohara M, Iwatsuki K, Tsujimoto G, Ohno H, Arita M, Itoh H, Hase K.
    • Journal Title

      Science

      Volume: 367 Issue: 6481 Pages: 8429-8429

    • DOI

      10.1126/science.aaw8429

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] DNA damage and expression of DNA methylation modulators in urine-derived cells of patients with hypertension and diabetes2020

    • Author(s)
      Hishikawa Akihito、Hayashi Kaori、Yoshimoto Norifumi、Nakamichi Ran、Homma Koichiro、Itoh Hiroshi
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1

    • DOI

      10.1038/s41598-020-60420-9

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of glomerular DNA damage and DNA methylation with one-year eGFR decline in IgA nephropathy2020

    • Author(s)
      Hayashi Kaori、Hishikawa Akihito、Hashiguchi Akinori、Azegami Tatsuhiko、Yoshimoto Norifumi、Nakamichi Ran、Tokuyama Hirobumi、Itoh Hiroshi
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1

    • DOI

      10.1038/s41598-019-57140-0

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] FCoR-Foxo1 Axis Regulates α-Cell Mass through Repression of Arx Expression2020

    • Author(s)
      Kodani Noriko、Nakae Jun、Kobayashi Masaki、Kikuchi Osamu、Kitamura Tadahiro、Itoh Hiroshi
    • Journal Title

      iScience

      Volume: 23 Issue: 1 Pages: 100798-100798

    • DOI

      10.1016/j.isci.2019.100798

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men2020

    • Author(s)
      Irie J, Inagaki E, Fujita M, Nakaya H, Mitsuishi M, Yamaguchi S, Yamashita K, Shigaki S, Ono T, Yukioka H, Okano H, Nabeshima YI, Imai SI, Yasui M, Tsubota K, Itoh H
    • Journal Title

      Endocrine Journal

      Volume: 67 Issue: 2 Pages: 153-160

    • DOI

      10.1507/endocrj.EJ19-0313

    • NAID

      130007802884

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] CASZ1b is a novel transcriptional corepressor of mineralocorticoid receptor2020

    • Author(s)
      Yokota Kenichi、Shibata Hirotaka、Kurihara Isao、Kobayashi Sakiko、Murai-Takeda Ayano、Itoh Hiroshi
    • Journal Title

      Hypertension Research

      Volume: 44 Issue: 4 Pages: 407-416

    • DOI

      10.1038/s41440-020-00562-5

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed

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Published: 2020-04-28   Modified: 2024-01-30  

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