| Budget Amount *help |
¥45,370,000 (Direct Cost: ¥34,900,000、Indirect Cost: ¥10,470,000)
Fiscal Year 2023: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2022: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2021: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2020: ¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
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| Outline of Final Research Achievements |
Bone is dynamically reborn while maintaining dynamic homeostasis, and this process is called "bone remodeling." While bone remodeling maintains healthy and strong bones, the insufficiency can lead to bone diseases. Bone remodeling is controlled by intercellular crosstalk between osteoclasts and osteoblasts which are the "executive cells" on the bone surface, and osteocytes which are the "commander cells" embedded in the bone. However, the complete picture has not yet been elucidated.
In this study, we elucidated the control mechanism of bone homeostasis by identifying molecules that understanding the mechanism of bone remodeling and its failure at the biological level. As a result, we established a new molecular basis for controlling bone diseases.
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