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Development of an in silico and Robotic-Assisted Drug Discovery System and Its Application to the Search for Therapeutic Agents against Chagas Disease

Research Project

Project/Area Number 20H00620
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Review Section Medium-sized Section 62:Applied informatics and related fields
Research InstitutionTokyo Institute of Technology

Principal Investigator

Masakazu Sekijima  東京工業大学, 情報理工学院, 准教授 (80371053)

Co-Investigator(Kenkyū-buntansha) 稲岡 健ダニエル  長崎大学, 熱帯医学研究所, 准教授 (10623803)
庄司 満  横浜薬科大学, 薬学部, 教授 (30339139)
平山 謙二  長崎大学, 熱帯医学・グローバルヘルス研究科, 教授 (60189868)
樺島 祥介  東京大学, 大学院理学系研究科(理学部), 教授 (80260652)
Project Period (FY) 2020-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥38,480,000 (Direct Cost: ¥29,600,000、Indirect Cost: ¥8,880,000)
Fiscal Year 2023: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2022: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2021: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2020: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Keywordsケモインフォマティクス / バイオインフォマティクス / 機械学習 / IT創薬 / スーパーコンピュータ / 創薬 / 分子動力学シミュレーション / 寄生原虫 / AI創薬 / 抗規制原虫薬 / ロボット / 自動合成
Outline of Research at the Start

顧みられない熱帯病と呼ばれる寄生虫・細菌感染症が熱帯地域を中心に蔓延している。近年、一つの薬を開発する費用と期間は26億ドルと13.5年とされており、機械学習を始めとする情報技術やロボット技術による効率的な創薬手法の開発が期待されている。本研究では、機械学習を用いた候補化合物を生成する生成モジュール、活性予測モジュール、物性・毒性予測を行う評価モジュールの開発、これらの予測に基づいたロボットによる化合物自動合成手法の確立、抗寄生原虫活性・毒性評価実験系の確立を行い、実験結果を随時学習モデルに反映し、新たな薬候補化合物の提案・合成・評価を行う仕組みを確立することを目指している。

Outline of Final Research Achievements

In this study, we developed a compound optimization method based on molecular graphs using deep reinforcement learning and successfully enhanced the activity of compounds targeting dopamine receptor D2 (DRD2). This method is suitable for exploring and optimizing user-defined compounds. We also generated compounds targeting TAO, for which Professor Inaoka at Nagasaki University has an evaluation system, using a compound generation model with multi-objective optimization, and conducted actual synthesis experiments. The synthesis experiments provided insights into compound synthesis that were not evident during AI prediction. These achievements are expected to contribute to the efficiency of drug discovery research.

Academic Significance and Societal Importance of the Research Achievements

本研究で開発した深層強化学習を用いた化合物最適化手法と多目的最適化による化合物生成モデルは、githubを通じてプログラムを広く公開しており創薬研究の効率化に寄与する学術的意義がある。特に、ユーザー定義の評価関数で化合物を探索・最適化できる点は、既知の化合物からの新薬開発を加速する。また、トリパノソーマ寄生原虫の治療薬開発への取り組みは、顧みられない熱帯病の治療薬開発を促進し、患者のQOLの向上と医療費の削減につながる可能性がある。さらに、AIでの予測だけでなく実際の合成実験を行うことで、創薬研究におけるAIと実験科学の融合の重要性を示した点も、学術的・社会的に意義深い。

Report

(6 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Annual Research Report
  • 2021 Annual Research Report
  • 2020 Comments on the Screening Results   Annual Research Report
  • Research Products

    (106 results)

All 2024 2023 2022 2021 2020 Other

All Int'l Joint Research (1 results) Journal Article (46 results) (of which Int'l Joint Research: 9 results,  Peer Reviewed: 46 results,  Open Access: 25 results) Presentation (57 results) (of which Int'l Joint Research: 12 results,  Invited: 9 results) Book (1 results) Remarks (1 results)

  • [Int'l Joint Research] インド工科大学マドラス校(インド)

    • Related Report
      2021 Annual Research Report
  • [Journal Article] Fumarate respiration of Fasciola flukes as a potential drug target2024

    • Author(s)
      Tashibu Atsushi、Inaoka Daniel Ken、Sakamoto Kimitoshi、Murakami Kenji、Zannatul Ferdoush、Kita Kiyoshi、Ichikawa-Seki Madoka
    • Journal Title

      Frontiers in Cellular and Infection Microbiology

      Volume: 13 Pages: 1302114-1302114

    • DOI

      10.3389/fcimb.2023.1302114

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Generating Gradients in the Energy Landscape Using Rectified Linear Type Cost Functions for Efficiently Solving 0/1 Matrix Factorization in Simulated Annealing2024

    • Author(s)
      Konoshima Makiko、Tamura Hirotaka、Kabashima Yoshiyuki
    • Journal Title

      Journal of the Physical Society of Japan

      Volume: 93 Issue: 4 Pages: 1-7

    • DOI

      10.7566/jpsj.93.044002

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PRA-Pred: Structure-based prediction of protein-RNA binding affinity2024

    • Author(s)
      Harini K.、Sekijima M.、Gromiha M. Michael
    • Journal Title

      International Journal of Biological Macromolecules

      Volume: 259 Pages: 129490-129490

    • DOI

      10.1016/j.ijbiomac.2024.129490

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aspects for development of novel antibacterial medicines using a vitamin D3 decomposition product in Helicobacter pylori infection2023

    • Author(s)
      Wanibuchi Kiyofumi、Hosoda Kouichi、Amgalanbaatar Avarzed、Ihara Masato、Takezawa Motoki、Sakai Yuki、Masui Hisashi、Shoji Mitsuru、Hayashi Shunji、Shimomura Hirofumi
    • Journal Title

      The Journal of Antibiotics

      Volume: 76 Issue: 11 Pages: 665-672

    • DOI

      10.1038/s41429-023-00651-w

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of polymer-immobilised acridinium catalyst and its application in photoinduced 1,4-addition to α,β-unsaturated carbonyl compounds2023

    • Author(s)
      Umezawa Misaki、Aoki Shoji、Okuno Yoshinori、Sato Yasuo、Wanibuchi Kiyofumi、Shoji Mitsuru
    • Journal Title

      Tetrahedron Letters

      Volume: 128 Pages: 154698-154698

    • DOI

      10.1016/j.tetlet.2023.154698

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Challenges Based on Antiplasmodial and Antiviral Activities of 7‐Chloro‐4‐aminoquinoline Derivatives2023

    • Author(s)
      Mizuta Satoshi、Mosaddeque Farhana、Tun Mya Myat Ngwe、Teklemichael Awet Alem、Taniguchi Mayumi、Hosokawa Masashi、Yamaguchi Tomoko、Makau Juliann、Huy Nguyen Tien、Mizukami Shusaku、Nishida Noriyuki、Morita Kouichi、Hirayama Kenji
    • Journal Title

      ChemMedChem

      Volume: 18 Issue: 7

    • DOI

      10.1002/cmdc.202200586

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-Trypanosoma cruzi activity of?Coptis?rhizome extract and its constituents2023

    • Author(s)
      Tayama Yuki、Mizukami Shusaku、Toume Kazufumi、Komatsu Katsuko、Yanagi Tetsuo、Nara Takeshi、Tieu Paul、Huy Nguyen Tien、Hamano Shinjiro、Hirayama Kenji
    • Journal Title

      Tropical Medicine and Health

      Volume: 51 Issue: 1

    • DOI

      10.1186/s41182-023-00502-2

    • Related Report
      2023 Annual Research Report 2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Biochemical characterization and identification of ferulenol and embelin as potent inhibitors of malate:quinone oxidoreductase from Campylobacter jejuni2023

    • Author(s)
      Kabongo Augustin Tshibaka、Acharjee Rajib、Sakura Takaya、Bundutidi Gloria Mavinga、Hartuti Endah Dwi、Davies Cadi、Gundogdu Ozan、Kita Kiyoshi、Shiba Tomoo、Inaoka Daniel Ken
    • Journal Title

      Frontiers in Molecular Biosciences

      Volume: 10 Pages: 1095026-1095026

    • DOI

      10.3389/fmolb.2023.1095026

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Compressed Sensing Radar Detectors Under the Row-Orthogonal Design Model: A Statistical Mechanics Perspective2023

    • Author(s)
      Na Siqi、Huang Tianyao、Liu Yimin、Takahashi Takashi、Kabashima Yoshiyuki、Wang Xiqin
    • Journal Title

      IEEE Transactions on Signal Processing

      Volume: 71 Pages: 2668-2682

    • DOI

      10.1109/tsp.2023.3297743

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Decision Theoretic Cutoff and ROC Analysis for Bayesian Optimal Group Testing2023

    • Author(s)
      Ayaka Sakata, Yoshiyuki Kabashima
    • Journal Title

      IEEE Transaction on Information Theory

      Volume: 69 Issue: 9 Pages: 5902-5920

    • DOI

      10.1109/tit.2023.3276696

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Average case analysis of Lasso under ultra sparse conditions2023

    • Author(s)
      Koki Okajima, Xiangming Meng, Takashi Takahashi, Yoshiyuki Kabashima
    • Journal Title

      Proceedings of The 26th International Conference on Artificial Intelligence and Statistics (PMLR206)

      Volume: - Pages: 11317-11330

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] On Model Selection Consistency of Lasso for High-Dimensional Ising Models2023

    • Author(s)
      Xiangming Meng, Tomoyuki Obuchi, Yoshiyuki Kabashima
    • Journal Title

      Proceedings of The 26th International Conference on Artificial Intelligence and Statistics (PMLR206)

      Volume: - Pages: 6783-6805

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gargoyles: An Open Source Graph-Based Molecular Optimization Method Based on Deep Reinforcement Learning2023

    • Author(s)
      Erikawa Daiki、Yasuo Nobuaki、Suzuki Takamasa、Nakamura Shogo、Sekijima Masakazu
    • Journal Title

      ACS Omega

      Volume: 8 Issue: 40 Pages: 37431-37441

    • DOI

      10.1021/acsomega.3c05430

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhancing the Performance of AlphaFold Through Modified Storage Method and Optimization of HHblits on TSUBAME3.0 Supercomputer2023

    • Author(s)
      Fujita Hayato、Nomura Akihiro、Endo Toshio、Sekijima Masakazu
    • Journal Title

      Proceedings of the 2023 Congress in Computer Science, Computer Engineering, & Applied Computing (CSCE)

      Volume: - Pages: 2140-2146

    • DOI

      10.1109/csce60160.2023.00351

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Predicting Chemical Reaction Product by Graph Transformer2023

    • Author(s)
      Makino Shunya、Yasuo Nobuaki、Sekijima Masakazu
    • Journal Title

      Proceedings of the 2023 Congress in Computer Science, Computer Engineering, & Applied Computing (CSCE)

      Volume: - Pages: 2147-2152

    • DOI

      10.1109/csce60160.2023.00352

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Discovery of a Hidden Trypanosoma cruzi Spermidine Synthase Binding Site and Inhibitors through In Silico, In Vitro, and X-ray Crystallography2023

    • Author(s)
      Yoshino Ryunosuke、Yasuo Nobuaki、Hagiwara Yohsuke、Ishida Takashi、Inaoka Daniel Ken、Amano Yasushi、Tateishi Yukihiro、Ohno Kazuki、Namatame Ichiji、Niimi Tatsuya、Orita Masaya、Kita Kiyoshi、Akiyama Yutaka、Sekijima Masakazu
    • Journal Title

      ACS Omega

      Volume: 8 Issue: 29 Pages: 25850-25860

    • DOI

      10.1021/acsomega.3c01314

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Quantized Compressed Sensing with Score-based Generative Models2023

    • Author(s)
      Xiangming Meng, Yoshiyuki Kabashima
    • Journal Title

      Proceedings of ICLR2023

      Volume: -

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Average case analysis of Lasso under ultra-sparse conditions2023

    • Author(s)
      Koki Okajima, Xiangming Meng, Takashi Takahashi, Yoshiyuki Kabashima
    • Journal Title

      Proceedings of The 26th International Conference on Artificial Intelligence and Statistics

      Volume: - Pages: 11317-11330

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] On Model Selection Consistency of Lasso for High-Dimensional Ising Models2023

    • Author(s)
      Xiangming Meng, Tomoyuki Obuchi, Yoshiyuki Kabashima
    • Journal Title

      Proceedings of The 26th International Conference on Artificial Intelligence and Statistics

      Volume: - Pages: 6783-6805

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Replicated Simulated Annealing with a Global-Best Reference for Efficient Hardware Implementation2022

    • Author(s)
      Konoshima Makiko、Tamura Hirotaka、Kabashima Yoshiyuki
    • Journal Title

      Journal of the Physical Society of Japan

      Volume: 91 Issue: 11

    • DOI

      10.7566/jpsj.91.113001

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Macroscopic Analysis of Vector Approximate Message Passing in a Model-Mismatched Setting2022

    • Author(s)
      Takahashi Takashi、Kabashima Yoshiyuki
    • Journal Title

      IEEE Transactions on Information Theory

      Volume: 68 Issue: 8 Pages: 5579-5600

    • DOI

      10.1109/tit.2022.3163342

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Multidimensional analyses of the pathomechanism caused by the non-catalytic GNE variant, c.620A>T, in patients with GNE myopathy2022

    • Author(s)
      Yoshioka Wakako、Iida Aritoshi、Sonehara Kyuto、Yamamoto Kazuki、Oya Yasushi、Mori-Yoshimura Madoka、Kurashige Takashi、Okubo Mariko、Ogawa Megumu、Matsuda Fumihiko、Higasa Koichiro、Hayashi Shinichiro、Nakamura Harumasa、Sekijima Masakazu、Okada Yukinori、Noguchi Satoru、Nishino Ichizo
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 21806-21806

    • DOI

      10.1038/s41598-022-26419-0

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An Improved Model for Predicting Compound Retrosynthesizability Using Machine Learning2022

    • Author(s)
      Ozawa Mami、Yasuo Nobuaki、Sekijima Masakazu
    • Journal Title

      Proceedings of the 2022 IEEE 22nd International Conference on Bioinformatics and Bioengineering (BIBE)

      Volume: - Pages: 210-216

    • DOI

      10.1109/bibe55377.2022.00052

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dephospho-Coenzyme A Kinase Is an Exploitable Drug Target against Plasmodium falciparum: Identification of Selective Inhibitors by High-Throughput Screening of a Large Chemical Compound Library2022

    • Author(s)
      Nurkanto Arif、Imamura Riyo、Rahmawati Yulia、Prabandari Erwahyuni Endang、Waluyo Danang、Annoura Takeshi、Yamamoto Kazuki、Sekijima Masakazu、Nishimura Yuki、Okabe Takayoshi、Shiba Tomoo、Shibata Norio、Kojima Hirotatsu、Duffy James、Nozaki Tomoyoshi
    • Journal Title

      Antimicrobial Agents and Chemotherapy

      Volume: 66 Issue: 11

    • DOI

      10.1128/aac.00420-22

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel Calcium-Binding Ablating Mutations Induce Constitutive RET Activity and Drive Tumorigenesis2022

    • Author(s)
      Tabata Junya、Nakaoku Takashi、Araki Mitsugu、Yoshino Ryunosuke、Kohsaka Shinji、Otsuka Ayaka、Ikegami Masachika、Ui Ayako、Kanno Shin-ichiro、Miyoshi Keiko、Matsumoto Shigeyuki、Sagae Yukari、Yasui Akira、Sekijima Masakazu、Mano Hiroyuki、Okuno Yasushi、Okamoto Aikou、Kohno Takashi
    • Journal Title

      Cancer Research

      Volume: 82 Issue: 20 Pages: 3751-3762

    • DOI

      10.1158/0008-5472.can-22-0834

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Toxicokinetic analysis of the anticoagulant rodenticides warfarin & diphacinone in Egyptian fruit bats (Rousettus aegyptiacus) as a comparative sensitivity assessment for Bonin fruit bats (Pteropus pselaphon)2022

    • Author(s)
      Takeda Kazuki、Manago Kosuke、Morita Ayuko、Kawai Yusuke K.、Yasuo Nobuaki、Sekijima Masakazu、Ikenaka Yoshinori、Hashimoto Takuma、Minato Ryuichi、Oyamada Yusuke、Horikoshi Kazuo、Suzuki Hajime、Ishizuka Mayumi、Nakayama Shouta M.M.
    • Journal Title

      Ecotoxicology and Environmental Safety

      Volume: 243 Pages: 113971-113971

    • DOI

      10.1016/j.ecoenv.2022.113971

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tuning of Bayesian optimization for materials synthesis: simulation of the one-dimensional case2022

    • Author(s)
      Nakayama Ryo、Shimizu Ryota、Haga Taishi、Kimura Takefumi、Ando Yasunobu、Kobayashi Shigeru、Yasuo Nobuaki、Sekijima Masakazu、Hitosugi Taro
    • Journal Title

      Science and Technology of Advanced Materials: Methods

      Volume: 2 Issue: 1 Pages: 119-128

    • DOI

      10.1080/27660400.2022.2066489

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Screening for Inhibitors of Main Protease in SARS-CoV-2: In Silico and In Vitro Approach Avoiding Peptidyl Secondary Amides2022

    • Author(s)
      Yamamoto Kazuki Z.、Yasuo Nobuaki、Sekijima Masakazu
    • Journal Title

      Journal of Chemical Information and Modeling

      Volume: 62 Issue: 2 Pages: 350-358

    • DOI

      10.1021/acs.jcim.1c01087

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Statistical potentials for RNA-protein interactions optimized by CMA-ES2022

    • Author(s)
      Kimura Takayuki、Yasuo Nobuaki、Sekijima Masakazu、Lustig Brooke
    • Journal Title

      Journal of Molecular Graphics and Modelling

      Volume: 110 Pages: 108044-108044

    • DOI

      10.1016/j.jmgm.2021.108044

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Assessing transfer entropy from biochemical data2022

    • Author(s)
      Imaizumi Takuya、Umeki Nobuhisa、Yoshizawa Ryo、Obuchi Tomoyuki、Sako Yasushi、Kabashima Yoshiyuki
    • Journal Title

      Physical Review E

      Volume: 105 Issue: 3 Pages: 1-13

    • DOI

      10.1103/physreve.105.034403

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] MERMAID: an open source automated hit-to-lead method based on deep reinforcement learning2021

    • Author(s)
      Erikawa Daiki、Yasuo Nobuaki、Sekijima Masakazu
    • Journal Title

      Journal of Cheminformatics

      Volume: 13 Issue: 1

    • DOI

      10.1186/s13321-021-00572-6

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Biochemical Studies of Mitochondrial Malate: Quinone Oxidoreductase from Toxoplasma gondii2021

    • Author(s)
      Acharjee Rajib、Talaam Keith、Hartuti Endah、Matsuo Yuichi、Sakura Takaya、Gloria Bundutidi、Hidano Shinya、Kido Yasutoshi、Mori Mihoko、Shiomi Kazuro、Sekijima Masakazu、Nozaki Tomoyoshi、Umeda Kousuke、Nishikawa Yoshifumi、Hamano Shinjiro、Kita Kiyoshi、Inaoka Daniel
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 22 Issue: 15 Pages: 7830-7830

    • DOI

      10.3390/ijms22157830

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Computer aided drug discovery review for infectious diseases with case study of anti-Chagas project2021

    • Author(s)
      Yasuo Nobuaki、Ishida Takashi、Sekijima Masakazu
    • Journal Title

      Parasitology International

      Volume: 83 Pages: 102366-102366

    • DOI

      10.1016/j.parint.2021.102366

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Matrix completion based on Gaussian parameterized belief propagation2021

    • Author(s)
      Okajima Koki、Kabashima Yoshiyuki
    • Journal Title

      Journal of Statistical Mechanics: Theory and Experiment

      Volume: 2021 Issue: 9 Pages: 093407-093407

    • DOI

      10.1088/1742-5468/ac21c9

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure learning in inverse Ising problems using ? <sub>2</sub>-regularized linear estimator2021

    • Author(s)
      Meng Xiangming、Obuchi Tomoyuki、Kabashima Yoshiyuki
    • Journal Title

      Journal of Statistical Mechanics: Theory and Experiment

      Volume: 2021 Issue: 5 Pages: 053403-053403

    • DOI

      10.1088/1742-5468/abfa10

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Efficient synthesis of 5-(hydroxymethyl)piperazin-2-ones using automatically prepared chiral bromocarboxylic acid and Garner’s aldehyde as versatile building blocks2021

    • Author(s)
      Masui Hisashi、Naito Kohei、Minoshima Mai、Kusayanagi Akira、Yosugi Sae、Shoji Mitsuru、Takahashi Takashi
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 40 Pages: 127961-127961

    • DOI

      10.1016/j.bmcl.2021.127961

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of charged mutation on aggregation of a pentapeptide: Insights from molecular dynamics simulations2021

    • Author(s)
      Prabakaran R.、Rawat Puneet、Yasuo Nobuaki、Sekijima Masakazu、Kumar Sandeep、Gromiha M. Michael
    • Journal Title

      Proteins: Structure, Function, and Bioinformatics

      Volume: 90 Issue: 2 Pages: 405-417

    • DOI

      10.1002/prot.26230

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Tackling Covid‐19 using disordered‐to‐order transition of residues in the spike protein upon angiotensin‐converting enzyme 2 binding2021

    • Author(s)
      Yesudhas Dhanusha、Srivastava Ambuj、Sekijima Masakazu、Gromiha M. Michael
    • Journal Title

      Proteins: Structure, Function, and Bioinformatics

      Volume: 89 Issue: 9 Pages: 1158-1166

    • DOI

      10.1002/prot.26088

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Identification of key interactions between SARS-CoV-2 main protease and inhibitor drug candidates2020

    • Author(s)
      Yoshino Ryunosuke、Yasuo Nobuaki、Sekijima Masakazu
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1

    • DOI

      10.1038/s41598-020-69337-9

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Knowledge, behaviour and attitudes towards Chagas disease among the Bolivian migrant population living in Japan: a cross-sectional study2020

    • Author(s)
      Ines Maria Iglesias Rodriguez、Mizukami Shusaku、Manh Dao Huy、Thuan Tieu Minh、Justiniano Hugo Alberto、Miura Sachio、Ito George、Huy Nguyen Tien、Smith Chris、Hirayama Kenji
    • Journal Title

      BMJ Open

      Volume: 10 Issue: 9 Pages: e032546-e032546

    • DOI

      10.1136/bmjopen-2019-032546

    • NAID

      120006988522

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Plasmodium falciparum multidrug resistance gene-1 polymorphisms in Northern Nigeria: implications for the continued use of artemether-lumefantrine in the region2020

    • Author(s)
      Adamu Auwal、Jada Mahmoud Suleiman、Haruna Hauwa Mohammed Sani、Yakubu Bassa Obed、Ibrahim Mohammed Auwal、Balogun Emmanuel Oluwadare、Sakura Takaya、Inaoka Daniel Ken、Kita Kiyoshi、Hirayama Kenji、Culleton Richard、Shuaibu Mohammed Nasir
    • Journal Title

      Malaria Journal

      Volume: 19 Issue: 1

    • DOI

      10.1186/s12936-020-03506-z

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Learning performance in inverse Ising problems with sparse teacher couplings2020

    • Author(s)
      Abbara Alia、Kabashima Yoshiyuki、Obuchi Tomoyuki、Xu Yingying
    • Journal Title

      Journal of Statistical Mechanics: Theory and Experiment

      Volume: 2020 Issue: 7 Pages: 073402-073402

    • DOI

      10.1088/1742-5468/ab8c3a

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Macroscopic Analysis of Vector Approximate Message Passing in a Model Mismatch Setting2020

    • Author(s)
      Takahashi Takashi、Kabashima Yoshiyuki
    • Journal Title

      Proceedings of 2020 IEEE International Symposium on Information Theory

      Volume: なし Pages: 1403-1408

    • DOI

      10.1109/isit44484.2020.9173999

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Semi-analytic approximate stability selection for correlated data in generalized linear models2020

    • Author(s)
      Takahashi Takashi、Kabashima Yoshiyuki
    • Journal Title

      Journal of Statistical Mechanics: Theory and Experiment

      Volume: 2020 Issue: 9 Pages: 093402-093402

    • DOI

      10.1088/1742-5468/ababff

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inferring Neuronal Couplings From Spiking Data Using a Systematic Procedure With a Statistical Criterion2020

    • Author(s)
      Terada Yu、Obuchi Tomoyuki、Isomura Takuya、Kabashima Yoshiyuki
    • Journal Title

      Neural Computation

      Volume: 32 Issue: 11 Pages: 2187-2211

    • DOI

      10.1162/neco_a_01324

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reconstructing Sparse Signals via Greedy Monte-Carlo Search2020

    • Author(s)
      Hayashi Kao、Obuchi Tomoyuki、Kabashima Yoshiyuki
    • Journal Title

      Journal of the Physical Society of Japan

      Volume: 89 Issue: 12 Pages: 124802-124802

    • DOI

      10.7566/jpsj.89.124802

    • NAID

      40022438412

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Presentation] Compressed sensing based on diffusion models2023

    • Author(s)
      Yoshiyuki Kabashima
    • Organizer
      ICTP Trieste
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Replica analysis of Lasso for ultra-sparse signals2023

    • Author(s)
      Yoshiyuki Kabashima
    • Organizer
      East Asia Joint Seminar on Statistical Physics
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 大自由度システムの統計学としての統計力学2023

    • Author(s)
      樺島祥介
    • Organizer
      2024年第71回応用物理学会春季学術講演会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 拡散モデルに基づく圧縮センシング2023

    • Author(s)
      樺島祥介
    • Organizer
      第52回情報計測オンラインセミナー
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] Knowledge, Attitude, and Practice of Mothers toward Chagas disease in La Guardia, Santa Cruz Department, Bolivia: A Cross-sectional Study2023

    • Author(s)
      Takehara Y, Trang TBL, Makram AM, Rashidul Hashan M, Altom A, Thanh VN, Elsheikh R, Iglesias-Rodriguez IM, Guzman Lijeron AY, Soria Medina NM, Quiroga Alpiri BN, Nishizawa JE, Huy NT, Hirayama K.
    • Organizer
      Annual meeting of American Society of Tropical Medicine and Hygiene 2023
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Risk factors for mother-to-child transmission of Trypanosoma cruzi and Hepatitis B in the cross-border area of Argentina and Paraguay2023

    • Author(s)
      Takahashi Y, Avila S, Correa S, Cardone K, Fernandez M, Crudo F, Sato M, Aiga H, Hirayama K, Periago MV.
    • Organizer
      Annual meeting of American Society of Tropical Medicine and Hygiene 2023
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Trypanosomal ASCT and alternative oxidase as tools to study Mycobacterium bioenergetics2023

    • Author(s)
      Mavinga Gloria Bundutidi, Ando Yuri, Matsuo Yuichi, Hayashishita Mizuki, Mochizuki Kota, Cook Gregory M., Sekijima Masakazu, Sakura Takaya, Hamano Shinjiro, Hirayama Kenji, Kita Kiyoshi, Ken Daniel Inaoka
    • Organizer
      11th Meeting GlycoNov/AdipoTryp
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Expression of an active ASCT/SCS cycle in Mycobacterium smegmatis confers resistance to Bedaquiline2023

    • Author(s)
      Mavinga Gloria Bundutidi, Ando Yuri, Matsuo Yuichi, Hayashishita Mizuki, Mochizuki Kota, Cook Gregory M., Sekijima Masakazu, Sakura Takaya, Hamano Shinjiro, Hirayama Kenji, Kita Kiyoshi, Ken Daniel Inaoka
    • Organizer
      Gordon Research Conferences on Bioenergetics, Proctor Academy, New Hampshire
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Structural insights into SCOT activity of TbASCT-D62N mutant2023

    • Author(s)
      Ken Daniel Inaoka, Mochizuki Kota, Balogun Emmanuel O., Fukuda Keisuke, Kurasawa Hana, Shiba Tomoo, Harada Shigeharu, Maze Muriel, Millerioux Yoann, Bringaud Frederic, Boshar Michael, Hirayama Kenji, Kita Kiyoshi
    • Organizer
      11th Meeting GlycoNov/AdipoTryp
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The trypanosome alternative oxidase as a target for drug development2023

    • Author(s)
      Ken Daniel Inaoka
    • Organizer
      Seminars in Pharmasciences
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Efficiency Improvements in Drug Discovery through Machine Learning and the Challenges to Overcome2023

    • Author(s)
      Masakazu Sekijima
    • Organizer
      CBI学会2023年大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Development of hit-to-lead molecular optimization by multi-objective Monte Carlo Tree Search2023

    • Author(s)
      Takamasa SUZUKI, Nobuaki YASUO, Masakazu Sekijima
    • Organizer
      CBI学会2023年大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] パレート最適を考慮したHit-to-Leadにおける多目的最適化手法の開発2023

    • Author(s)
      鈴木敬将・安尾信明・関嶋政和
    • Organizer
      情報処理学会 第143回MPS・第74回BIO合同研究発表会
    • Related Report
      2023 Annual Research Report
  • [Presentation] タンパク質ーリガンド結合部位の特徴量化の改善に関する研究2023

    • Author(s)
      塩澤理紗・安尾信明・関嶋政和
    • Organizer
      情報処理学会 第143回MPS・第74回BIO合同研究発表会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Statistical mechanics approach to linear regression2023

    • Author(s)
      Y. Kabashima
    • Organizer
      Functional Inference and Machine Intelligence (FIMI) 2023
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 拡散モデルに基づく圧縮センシング2023

    • Author(s)
      樺島祥介
    • Organizer
      公開シンポジウム「データ駆動科学と情報計測の新展開」(DDIMA)
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 光酸化還元反応を用いるα,β-不飽和カルボン酸への直截的光1,4-付加およびアクリジニウム型固相光触媒の開発2023

    • Author(s)
      梅沢岬, 奥野義規, 佐藤康夫, 青木昭二, 庄司満
    • Organizer
      日本薬学会第143年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] コチレニンAアグリコンモデルの合成研究2023

    • Author(s)
      宮田拓真, スヌヴエリゼ, 鰐渕清史, 庄司満
    • Organizer
      日本薬学会第143年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Transformerを用いたグラフ翻訳による分子最適化手法の開発2023

    • Author(s)
      牧野峻也, 安尾信明, 関嶋政和
    • Organizer
      情報処理学会 第85回全国大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] タンパク質のリガンド結合部位の特徴量化手法の改善に関する研究2023

    • Author(s)
      塩澤理紗, 安尾信明, 関嶋政和
    • Organizer
      情報処理学会 第85回全国大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] パレート最適化MCTSを用いたde novo分子生成手法の開発2023

    • Author(s)
      鈴木敬将, 安尾信明, 関嶋政和
    • Organizer
      情報処理学会 第85回全国大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] パレート最適化を用いた多目的最適なde novo分子生成2023

    • Author(s)
      鈴木 敬将, Ma Dian, 中村 彰悟, 安尾 信明, 関嶋 政和
    • Organizer
      日本薬学会第143年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Assessing transfer entropy from biochemical data2022

    • Author(s)
      Y. Kabashima
    • Organizer
      Nobel Symposia: Predictability in Science in the Age of AI, STIAS
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Assessing transfer entropy from biochemical data2022

    • Author(s)
      Y. Kabashima
    • Organizer
      DYNAMICS DAYS ASIA PACIFIC (DDAP12)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] EXPRESSION OF TRYPANOSOMAL ACETATE: SUCCINATE COA TRANSFERASE IS SUFFICIENT TO DEVELOP RESISTANCE TO THE ATP SYNTHASE INHIBITOR BEDAQUILINE IN MYCOBACTERIUM SMEGMATIS2022

    • Author(s)
      Bundutidi M. G, Ando Y., Matsuo Y., Nakatani Y., Kiel H., Cook G. M., Sakura T., Hamano S, Hirayama K. and Kita K., Inaoka D. K.
    • Organizer
      Spring School “Trypanosomatid Metabolism” 10th Meeting GLYCONOV/ADIPOTRYP
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] α,β-不飽和カルボン酸への直截的光1,4-付加および固相触媒の開発2022

    • Author(s)
      梅沢岬, 川瀨美咲, 小室拓海, 奥野義規, 佐藤康夫, 青木昭二, 鰐渕清史, 庄司満
    • Organizer
      第66回 日本薬学会関東支部大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] エポキシドとβ-ラクトンの開環を伴う3成分連結反応に関する研究2022

    • Author(s)
      庄子頑鋼, 菊谷元, 岡田彩, 増井悠, 高橋孝志, 庄司満
    • Organizer
      第66回 日本薬学会関東支部大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 機械学習を用いた化合物の最適化と創薬への応用2022

    • Author(s)
      関嶋政和
    • Organizer
      日本薬学会第143年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] In Silico and In Vitro Screening for Inhibitors of SARSCoV-2 Main Protease Avoiding Peptidyl Secondary Amides2022

    • Author(s)
      Kazuki Yamamoto, Nobuyuki Yasuo, Masakazu Sekijima
    • Organizer
      CBI学会2022年大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Prediction of Protein Binding Region on RNA with Transformer and Attention Augmentation2022

    • Author(s)
      Takayuki Kimura, Nobuyuki Yasuo, Masakazu Sekijima
    • Organizer
      CBI学会2022年大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Hit Identification for SARS-CoV-2 Main Protease Using Convolutional Neural Network2022

    • Author(s)
      Nobuyuki Yasuo, Hiroshi Yoda, Masakazu Sekijima
    • Organizer
      CBI学会2022年大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Multi-Objective Molecular Optimization Using Monte Carlo Tree Search2022

    • Author(s)
      Suzuki Takamasa, Ma Dian, Nobuyuki Yasuo, Masakazu Sekijima
    • Organizer
      CBI学会2022年大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] An Enhanced Machine Learning Models for Predicting Retrosynthesis Accessibility2022

    • Author(s)
      Mami Ozawa, Nobuyuki Yasuo, Masakazu Sekijima
    • Organizer
      CBI学会2022年大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Molecular Optimization by Graph Generative Model using Transformers2022

    • Author(s)
      Shunya Makino, Nobuyuki Yasuo, Masakazu Sekijima
    • Organizer
      CBI学会2022年大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Prediction of Chemical Reaction Type with Hierarchical Graph Neural Networks2022

    • Author(s)
      Tatsuya Ishimoto, Nobuyuki Yasuo, Masakazu Sekijima
    • Organizer
      CBI学会2022年大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 光酸化還元反応を用いるα,β-不飽和カルボン酸への 直截的1,4-付加および固相光触媒の開発2022

    • Author(s)
      梅沢岬, 川瀨美咲, 奥野義規, 佐藤康夫, 青木昭, 鰐渕清史, 庄司満
    • Organizer
      日本化学会 第102春季年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 可視光を用いるベンジル位の酸化的エーテル化に関する研究2022

    • Author(s)
      山口舞佳, 庄司満
    • Organizer
      日本化学会 第102春季年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 光酸化還元反応を用いたセサミン類の合成2022

    • Author(s)
      鰐渕清史, 梅沢岬, 池田航, 庄司満
    • Organizer
      日本化学会 第102春季年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 有機分子触媒を用いた可視光エステル化の開発2022

    • Author(s)
      栁澤菜穂, 山口舞佳, 庄司満
    • Organizer
      日本薬学会 第142年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] L1正則化付き逆イジング問題の理論解析:統計力学的アプローチ2022

    • Author(s)
      Xiangming Meng, 小渕智之, 樺島祥介
    • Organizer
      日本物理学会第77回年次大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 線形制約下におけるSCAD最小化問題の解について2022

    • Author(s)
      石井智, 高橋昂, 小渕智之, 坂田綾香, 樺島祥介
    • Organizer
      日本物理学会第77回年次大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 生化学反応データからの移動エントロピーの評価2022

    • Author(s)
      今泉拓也, 梅木伸久, 吉澤亮, 小渕智之, 佐甲靖志, 樺島祥介
    • Organizer
      日本物理学会第77回年次大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 機械学習を用いた蛋白質のリガンド結合部位の形状を考慮した化合物の生成手法の開発2022

    • Author(s)
      村田翔太朗,安尾信明,関嶋政和
    • Organizer
      情報処理学会 第84回全国大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 深層強化学習による任意の分子を出発点とした分子最適化手法の開発2022

    • Author(s)
      恵利川大樹,安尾信明,関嶋政和
    • Organizer
      情報処理学会 第84回全国大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] In silico drug design by Molecular Generative Model and Docking2022

    • Author(s)
      Dian Ma, 安尾信明, 関嶋政和
    • Organizer
      情報処理学会 第69回バイオ研究発表会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 機械学習によるタンパク質のアポ構造からホロ構造の予測手法の開発2022

    • Author(s)
      李 明曄, 安尾信明, 関嶋政和
    • Organizer
      情報処理学会 第69回バイオ研究発表会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 任意の分子を出発点とするグラフベースの分子最適化手法の開発2022

    • Author(s)
      恵利川大樹, 安尾信明, 関嶋政和
    • Organizer
      情報処理学会 第69回バイオ研究発表会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 機械学習による化合物の逆合成解析可能性予測手法の開発2022

    • Author(s)
      小澤真実, 安尾信明, 関嶋政和
    • Organizer
      情報処理学会 第69回バイオ研究発表会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 光酸化還元反応を用いるα,β-不飽和カルボン酸への直截的1,4-付加およびアクリジン類縁体の触媒能の評価2021

    • Author(s)
      梅沢岬, 平濱俊哉, 庄司満
    • Organizer
      第65回日本薬学会関東支部大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ガウス型確率伝搬法による行列補完2021

    • Author(s)
      岡島光希, 樺島祥介
    • Organizer
      日本物理学会2021年秋季大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 個数制限のないナップザック問題の統計力学的解析2021

    • Author(s)
      中村優太, 高橋昂, 樺島祥介
    • Organizer
      日本物理学会2021年秋季大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 標本分散共分散行列の漸近固有値分布に関する統計力学的解析2021

    • Author(s)
      森田祐亮, 高橋昂, 樺島祥介
    • Organizer
      日本物理学会2021年秋季大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 新薬研究・開発における人工知能の適用と高度化2021

    • Author(s)
      関嶋政和
    • Organizer
      日本薬学会第141回年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 生薬を用いたクルーズトリパノソーマに対する新規抗原虫薬の探索研究2021

    • Author(s)
      田山雄基、水上修作、當銘一文、小松かつ子、稲岡健ダニエル、平山謙二
    • Organizer
      第90回日本寄生虫学会大会・第32回日本臨床寄生虫学会大会 合同大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] COVID-19と将来の感染症に向き合うシミュレーションと機械学習基盤2020

    • Author(s)
      関嶋政和
    • Organizer
      第9回生命医薬情報学連合大会 (IIBMP2020)
    • Related Report
      2020 Annual Research Report
  • [Presentation] Generation of derivative for small organic compound via Monte Carlo Tree Search2020

    • Author(s)
      Daiki Erikawa, Nobuaki Yasuo and Masakazu Sekijima
    • Organizer
      第9回生命医薬情報学連合大会(IIBMP2020)
    • Related Report
      2020 Annual Research Report
  • [Presentation] Augmented Realityによる創薬のためのタンパク質・リガンド可視化システムの開発2020

    • Author(s)
      小山 敦史 , 川田 信吾 , 坂本 亘 , 安尾 信明 , 関嶋 政和
    • Organizer
      情報処理学会研究報告数理モデル化と問題解決(MPS),2020-MPS-129(7),1-4 (2020-07-20)
    • Related Report
      2020 Annual Research Report
  • [Book] 革新的AI創薬2022

    • Author(s)
      小長谷 明彦監修(第3章第1節担当)
    • Total Pages
      390
    • Publisher
      エヌ・ティー・エス
    • ISBN
      4860437888
    • Related Report
      2022 Annual Research Report
  • [Remarks] Mothra

    • URL

      https://github.com/sekijima-lab/Mothra

    • Related Report
      2023 Annual Research Report

URL: 

Published: 2020-04-28   Modified: 2025-01-30  

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