Molecular pathogenesis of human disorders associated with deficiencies in the DNA repair and environmental stress response systems

• Project/Area Number: 20H00629
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Medium-sized Section 63:Environmental analyses and evaluation and related fields
• Research Institution: Nagoya University
• Principal Investigator: 荻 朋男 名古屋大学, 環境医学研究所, 教授 (80508317)
• Co-Investigator(Kenkyū-buntansha): 光武 範吏 長崎大学, 原爆後障害医療研究所, 教授 (50404215) ; 真下 知士 東京大学, 医科学研究所, 教授 (80397554)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥45,370,000 (Direct Cost: ¥34,900,000、Indirect Cost: ¥10,470,000); Fiscal Year 2022: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000); Fiscal Year 2021: ¥15,730,000 (Direct Cost: ¥12,100,000、Indirect Cost: ¥3,630,000); Fiscal Year 2020: ¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
• Keywords: 環境ストレス・環境変異原 / DNA修復・転写共役修復 / ゲノムインスタビリティ / DNA修復欠損性疾患 / がん・老化関連疾患

Outline of Research at the Start

生体内外の環境に由来する様々なストレス (環境ストレス)に対して、生物が適切な遺伝子発現の制御と遺伝情報の恒常性を維持するために必要となる、「環境ストレス応答・ゲノム修復システム」の全体像を理解する。また、その破綻により発症するがん、老化、代謝異常などのヒト疾患の病態解明をおこなう。これにより、将来的な治療法・予防法開発に結びつく知識の蓄積を目指す。

Outline of Annual Research Achievements

環境ストレスの多くは、生物の遺伝情報が格納されるゲノムDNAに損傷を誘発する。DNA損傷は適切な遺伝子の発現を妨げることで、細胞機能の維持に障害をきたすと同時に、DNA合成を阻害し遺伝情報の劣化をもたらす。このため、環境ストレスへの過度な曝露は、老化や発がんを含む様々な疾患の発症と密接に関係する。本研究では、生体内外の環境に由来する様々なストレスに起因するDNA損傷に対する、DNA修復機構や環境ストレス応答機構の分子メカニズムの作動原理と、これらが障害されることで生じる生体影響について、トランスオミクス解析 (ゲノム/遺伝子発現/モデル動物/ヒト疾患症例)を用いた横断的な研究により理解を深め、関連するヒト疾患の病態解明を目指している。
環境ストレス応答機構に異常を持つ複数系統のモデルマウスについて、継続した解析を実施した。その中で、アルデヒド代謝異常を示すモデルマウスと転写共役修復機構に異常を示すモデルマウスについて解析したところ、アルデヒド代謝異常と転写共役修復異常をそれぞれ個別に示す個体と比較して、両者の異常を同時に示す個体では、表現型がより重篤になることが判明した。アルデヒド代謝異常と転写共役修復機構の関係について、より詳細な検討を進めるため、DNA損傷の1種であるDNA-蛋白質間架橋 (DNA-protein crosslink: DPC)の発生と修復をゲノムワイドに検出する新たな技術としてDPC-seqを構築した。DPC-seq解析、精密質量分析による相互作用解析、モデル細胞を用いた分子・細胞生物学的解析から、転写が活発に行われているゲノム領域のDPC除去に転写共役修復機構が関与することが明らかとなった。

Research Progress Status

令和4年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

令和4年度が最終年度であるため、記入しない。

Research Products

• [Int'l Joint Research] Sussex Univ./GDSC(英国)
• [Int'l Joint Research] LUMC(オランダ)
• [Int'l Joint Research] CNR(イタリア)
• [Int'l Joint Research] Sussex Univ./GDSC(英国)
• [Int'l Joint Research] LUMC(オランダ)
• [Int'l Joint Research] CNR(イタリア)
• [Int'l Joint Research] Sussex Univ./GDSC(英国)
• [Int'l Joint Research] LUMC(オランダ)
• [Int'l Joint Research] CNR(イタリア)
• [Journal Article] Endogenous aldehyde-induced DNA-protein crosslinks are resolved by transcription-coupled repair (2024)
  • Author(s): Oka Yasuyoshi、Nakazawa Yuka、Shimada Mayuko、Ogi Tomoo
  • Journal Title: Nature Cell Biology Volume: - Issue: 5 Pages: 784-796
  • DOI: 10.1038/s41556-024-01401-2
  • Peer Reviewed / Open Access
• [Journal Article] A case of Cockayne syndrome with unusually mild clinical manifestations (2023)
  • Author(s): Tsujimoto Mariko、Nakano Eiji、Nakazawa Yuka、Kanda Fumio、Ueda Takehiro、Ogi Tomoo、Nishigori Chikako
  • Journal Title: The Journal of Dermatology Volume: 50 Issue: 4 Pages: 541-545
  • DOI: 10.1111/1346-8138.16679
  • Peer Reviewed / Open Access
• [Journal Article] Deep intronic founder mutations identified in the ERCC4/XPF gene are potential therapeutic targets for a high-frequency form of xeroderma pigmentosum (2023)
  • Author(s): Senju Chikako、Nakazawa Yuka、Oso Taichi、Shimada Mayuko、Kato Kana、Matsuse Michiko、Tsujimoto Mariko、Masaki Taro、Miyazaki Yasushi、Fukushima Satoshi、Tateishi Satoshi、Utani Atsushi、Murota Hiroyuki、Tanaka Katsumi、Mitsutake Norisato、Moriwaki Shinichi、Nishigori Chikako、Ogi Tomoo
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 120 Issue: 27
  • DOI: 10.1073/pnas.2217423120
  • Peer Reviewed / Open Access
• [Journal Article] Lysosomal cholesterol overload in macrophages promotes liver fibrosis in a mouse model of NASH (2023)
  • Author(s): Itoh Michiko、Tamura Atsushi、Kanai Sayaka、Tanaka Miyako、Kanamori Yohei、Shirakawa Ibuki、Ito Ayaka、Oka Yasuyoshi、Hidaka Isao、Takami Taro、Honda Yasushi、Maeda Mitsuyo、Saito Yasuyuki、Murata Yoji、Matozaki Takashi、Nakajima Atsushi、Kataoka Yosky、Ogi Tomoo、Ogawa Yoshihiro、Suganami Takayoshi
  • Journal Title: Journal of Experimental Medicine Volume: 220 Issue: 11
  • DOI: 10.1084/jem.20220681
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Mitochondria-associated membrane collapse impairs TBK1-mediated proteostatic stress response in ALS (2023)
  • Author(s): Watanabe Seiji、Murata Yuri、Oka Yasuyoshi、Oiwa Kotaro、Horiuchi Mai、Iguchi Yohei、Komine Okiru、Sobue Akira、Katsuno Masahisa、Ogi Tomoo、Yamanaka Koji
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 120 Issue: 47
  • DOI: 10.1073/pnas.2315347120
  • Peer Reviewed / Open Access
• [Journal Article] Two patients with Hailey-Hailey disease with novel pathogenic ATP2C1 variants suggesting possible genotype/phenotype correlations (2023)
  • Author(s): Omi Michiya、Takeichi Takuya、Ito Yasutoshi、Yoshikawa Takenori、Mizutani Yuki、Nagai Miki、Seishima Mariko、Ogi Tomoo、Muro Yoshinao、Akiyama Masashi
  • Journal Title: The Journal of Dermatology Volume: - Issue: 6
  • DOI: 10.1111/1346-8138.17081
  • Peer Reviewed
• [Journal Article] Patients with keratinization disorders due to ABCA12 variants showing pityriasis rubra pilaris phenotypes. (2023)
  • Author(s): Takeichi T, Hamada T, Yamamoto M, Ito Y, Kawaguchi A, Kobashi H, Yoshikawa T, Koga H, Ishii N, Nakama T, Muro Y, Ogi T, Akiyama M.
  • Journal Title: J Dermatol. Volume: 51 Issue: 1 Pages: 101-105
  • DOI: 10.1111/1346-8138.16967
  • Peer Reviewed
• [Journal Article] Germline variants in tumor suppressor FBXW7 lead to impaired ubiquitination and a neurodevelopmental syndrome (2022)
  • Author(s): Stephenson Sarah E.M.、(他70名)、Ogi Tomoo、(他33名)、Tan Tiong Yang
  • Journal Title: The American Journal of Human Genetics Volume: 109 Issue: 4 Pages: 601-617
  • DOI: 10.1016/j.ajhg.2022.03.002
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Epithelioid cell granuloma formation in CARD14-associated papulosquamous eruptions. (2022)
  • Author(s): Takeichi T, Ikeda K, Muro Y, Ogi T, Morizane S, Akiyama M.
  • Journal Title: J Eur Acad Dermatol Venereol. Volume: 36 Issue: 5
  • DOI: 10.1111/jdv.17890
  • Peer Reviewed
• [Journal Article] Expanding the phenotypic spectrum of ARCN1-related syndrome. (2022)
  • Author(s): Ritter AL, et.al
  • Journal Title: Genet Med. Volume: S1098-3600 Issue: 6 Pages: 00651-7
  • DOI: 10.1016/j.gim.2022.02.005
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Case of ichthyosis with confetti caused by KRT10 mutation, complicated with multiple malignant melanomas. (2022)
  • Author(s): Ito Yasutoshi、Takeichi Takuya、Nakagawa Koichi、Tanahashi Kana、Muro Yoshinao、Ogi Tomoo、Akiyama Masashi
  • Journal Title: The Journal of Dermatology Volume: 49 Issue: 7
  • DOI: 10.1111/1346-8138.16348
  • Peer Reviewed
• [Journal Article] Deep Phenotyping of Superficial Epidermolytic Ichthyosis due to a Recurrent Mutation in KRT2 (2022)
  • Author(s): Suzuki Yuika、Takeichi Takuya、Tanahashi Kana、Muro Yoshinao、Suga Yasushi、Ogi Tomoo、Akiyama Masashi
  • Journal Title: International Journal of Molecular Sciences Volume: 23 Issue: 14 Pages: 7791-7791
  • DOI: 10.3390/ijms23147791
  • Peer Reviewed / Open Access
• [Journal Article] The iodide transporter Slc26a7 impacts thyroid function more strongly than Slc26a4 in mice. (2022)
  • Author(s): Yamaguchi N, Suzuki A, Yoshida A, Tanaka T, Aoyama K, Oishi H, Hara Y, Ogi T, Amano I, Kameo S, Koibuchi N, Shibata Y, Ugawa S, Mizuno H, Saitoh S
  • Journal Title: Sci Rep. Volume: 12 Issue: 1 Pages: 11259-11259
  • DOI: 10.1038/s41598-022-15151-4
  • Peer Reviewed / Open Access
• [Journal Article] Ceramide profiling of stratum corneum in Sjogren-Larsson syndrome (2022)
  • Author(s): Arai Ayami, Takeichi Takuya, Wakamoto Hiroyuki, Sassa Takayuki, Ito Yasutoshi, Murase Yuya, Ogi Tomoo, Akiyama Masashi, Kihara Akio
  • Journal Title: Journal of Dermatological Science Volume: 107 Issue: 3 Pages: 114-122
  • DOI: 10.1016/j.jdermsci.2022.08.003
  • Peer Reviewed
• [Journal Article] Aicardi-Goutieres syndrome with SAMHD1 deficiency can be diagnosed by unscheduled DNA synthesis test (2022)
  • Author(s): Senju C, Nakazawa Y, Shimada M, Iwata D, Matsuse M, Tanaka K, Miyazaki Y, Moriwaki S, Mitsutake N, Ogi T.
  • Journal Title: Frontiers in Pediatrics Volume: 10 Pages: 1048002-1048002
  • DOI: 10.3389/fped.2022.1048002
  • Peer Reviewed / Open Access
• [Journal Article] Global landscape of replicative DNA polymerase usage in the human genome (2022)
  • Author(s): Koyanagi Eri、Kakimoto Yoko、Minamisawa Tamiko、Yoshifuji Fumiya、Natsume Toyoaki、Higashitani Atsushi、Ogi Tomoo、Carr Antony M.、Kanemaki Masato T.、Daigaku Yasukazu
  • Journal Title: Nature Communications Volume: 13 Issue: 1 Pages: 7221-7221
  • DOI: 10.1038/s41467-022-34929-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Whole-exome analysis of 177 pediatric patients with undiagnosed diseases. (2022)
  • Author(s): Narita K, Muramatsu H, Narumi S, Nkawa T, Okumura A, et al.
  • Journal Title: Sci Rep Volume: 12(1) Issue: 1 Pages: 14589-14589
  • DOI: 10.1038/s41598-022-14161-6
  • Peer Reviewed / Open Access
• [Journal Article] Transcription-Coupled DNA Repair: From Mechanism to Human Disorder (2021)
  • Author(s): van den Heuvel Diana、van der Weegen Yana、Boer Daphne E.C.、Ogi Tomoo、Luijsterburg Martijn S.
  • Journal Title: Trends in Cell Biology Volume: 31 Issue: 5 Pages: 359-371
  • DOI: 10.1016/j.tcb.2021.02.007
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] ELOF1 is a transcription-coupled DNA repair factor that directs RNA polymerase II ubiquitylation (2021)
  • Author(s): van der Weegen Yana、(著者19人)、Ogi Tomoo、Wolthuis Rob M. F.、Luijsterburg Martijn S.
  • Journal Title: Nature Cell Biology Volume: 23 Issue: 6 Pages: 595-607
  • DOI: 10.1038/s41556-021-00688-9
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Dealing with transcription-blocking DNA damage: Repair mechanisms, RNA polymerase II processing and human disorders (2021)
  • Author(s): Jia Nan、Guo Chaowan、Nakazawa Yuka、van den Heuvel Diana、Luijsterburg Martijn S.、Ogi Tomoo
  • Journal Title: DNA Repair Volume: 106 Pages: 103192-103192
  • DOI: 10.1016/j.dnarep.2021.103192
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Protein instability associated with AARS1 and MARS1 mutations causes Trichothiodystrophy (2021)
  • Author(s): Botta E, Theil AF, Raams A, Caligiuri G, Giachetti S, Bione S, Accadia M, Lombardi A, Smith DEC, Mendes MI, Swagemakers SMA, van der Spek PJ, Salomons GS, Hoeijmakers JHJ, Yesodharan D, Nampoothiri S, Ogi T, Lehmann AR, Orioli D, Vermeulen W.
  • Journal Title: Human Molecular Genetics Volume: 30 Issue: 18 Pages: 1711-1720
  • DOI: 10.1093/hmg/ddab123
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Updated allele frequencies of SERPINB7 founder mutations in Asian patients with Nagashima-type palmoplantar keratosis/keratoderma. (2021)
  • Author(s): Ito Y, Takeichi T, Ikeda K, Tanahashi K, Yoshikawa T, Murase Y, Muro Y, Kawakami Y, Nakamura Y, Matsuyama K, Muto J, Oiso N, Morizane S, Sugiura K, Suga Y, Seishima M, Kawada A, Ogi T, Akiyama M.
  • Journal Title: J Dermatol Sci Volume: 103 Issue: 2 Pages: 116-119
  • DOI: 10.1016/j.jdermsci.2021.06.002
  • NAID: 120007190665
  • Peer Reviewed
• [Journal Article] Predominant cellular mitochondrial dysfunction in the TOP3A gene-caused Bloom syndrome-like disorder (2021)
  • Author(s): Jiang Wenjun、Jia Nan、Guo Chaowan、Wen Juan、Wu Lingqian、Ogi Tomoo、Zhang Huiwen
  • Journal Title: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease Volume: 1867 Issue: 6 Pages: 166106-166106
  • DOI: 10.1016/j.bbadis.2021.166106
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Digenic mutations in ALDH2 and ADH5 impair formaldehyde clearance and cause a multisystem disorder, AMeD syndrome (2020)
  • Author(s): Oka Y, Hamada M, Nakazawa Y, ..., Tanaka M, Suganami T, Nakada S, Mitsutake N, Hara Y, Kato K, ..., Kaneko H, Matsumoto N, Matsuda F, Matsuo K, Takahashi Y, Mashimo T, Kojima S, Ogi T
  • Journal Title: Science Advances Volume: 6 Issue: 51 Pages: 7197-7197
  • DOI: 10.1126/sciadv.abd7197
  • Peer Reviewed / Open Access
• [Journal Article] Biallelic VPS35L pathogenic variants cause 3C/Ritscher-Schinzel-like syndrome through dysfunction of retriever complex. (2020)
  • Author(s): Kato K, Okuno Y, Vasilev FF, Otomo T, Oishi H, Muramatsu H, Kawano Y, Oka Y, Nakazawa Y, Ogi T, Takahashi Y, Saitoh S.
  • Journal Title: Journal of Medical genetics Volume: 57 Issue: 4 Pages: 245-253
  • DOI: 10.1136/jmedgenet-2019-106213
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Topoisomerase I-driven repair of UV-induced damage in NER-deficient cells (2020)
  • Author(s): Saha Liton Kumar、Wakasugi Mitsuo、Akter Salma、Prasad Rajendra、Wilson Samuel H.、Shimizu Naoto、Sasanuma Hiroyuki、Huang Shar-yin Naomi、Agama Keli、Pommier Yves、Matsunaga Tsukasa、Hirota Kouji、Iwai Shigenori、Nakazawa Yuka、Ogi Tomoo、Takeda Shunichi
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 117 Issue: 25 Pages: 14412-14420
  • DOI: 10.1073/pnas.1920165117
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Expanding the phenotype of biallelic loss‐of‐function variants in the <scp> <i>NSUN2</i> </scp> gene: Description of four individuals with juvenile cataract, chronic nephritis, or brain anomaly as novel complications (2020)
  • Author(s): Kato Kohji、Mizuno Seiji、Morton Jenny、Toyama Miho、Hara Yuichiro、Wasmer Evangeline、Lehmann Alan、Ogi Tomoo
  • Journal Title: American Journal of Medical Genetics Part A Volume: 185 Issue: 1 Pages: 282-285
  • DOI: 10.1002/ajmg.a.61927
  • Peer Reviewed / Int'l Joint Research
• [Presentation] Deep intronic mutations identified in XP-F cases are potential therapeutic targets for xeroderma pigm entosum (2023)
  • Author(s): Nakazawa Y, Senju C, Oso T, Kato K, Shimada M, Ogi T
  • Organizer: The EXPS Annual Symposium
  • Int'l Joint Research / Invited
• [Presentation] DNA修復機構の異常により発症する光線過敏を伴う遺伝性皮膚疾患の分子病態 (2023)
  • Author(s): 荻朋男
  • Organizer: 第74回日本皮膚科学会中部支部学術大会
  • Invited
• [Presentation] Transcription-coupled repair of aldehyde-induced DNA damage (2023)
  • Author(s): 岡泰由, 荻朋男
  • Organizer: 第96回日本生化学会大会シンポジウム「多面化したDNA修復研究」
  • Invited
• [Presentation] DNA損傷に対する生体内防御機構の理解とその破綻による疾患の分子病態 (2023)
  • Author(s): 荻朋男
  • Organizer: 令和5年度 国立大学附置研究所・センター会議 第2部会シンポジウム
  • Invited
• [Presentation] Ubiquitination of RNA polymerase II and transcription-coupled repair (2022)
  • Author(s): Ogi T
  • Organizer: Webinar for the IBS Center for Genomic Integrity
  • Int'l Joint Research / Invited
• [Presentation] 転写共役修復とヒトの疾患 (2022)
  • Author(s): 荻朋男
  • Organizer: 日本遺伝学会第94回大会ワークショップ
  • Invited
• [Presentation] ゲノム安定維持機構の分子メカニズムとその破綻により発症する疾患の病態解明 (2022)
  • Author(s): 荻朋男
  • Organizer: 第83回応用物理学会秋季学術講演会シンポジウム
  • Invited
• [Presentation] RNA polymerase II ubiquitination regulates transcription-coupled repair (2022)
  • Author(s): Ogi T
  • Organizer: The 29th Federation of Asian and Oceanian Biochemists and Molecular Biologists Conference & the 2022 Chinese Society of Biochemistry and Molecular Biology Online Conference
  • Int'l Joint Research / Invited
• [Presentation] Genetic Diagnosis of Cockayne Syndrome (2022)
  • Author(s): Ogi T
  • Organizer: Amy and Friends
  • Int'l Joint Research / Invited
• [Presentation] 転写共役修復機構の分子メカニズムとその破綻による生体影響の解明 (2022)
  • Author(s): 中沢由華, 岡泰由, 森永浩伸, 何予希, 荻朋男
  • Organizer: 第45回日本分子生物学会年会
• [Presentation] Digenic inheritanceにより発症するゲノム不安定性疾患の分子病態 -内因性アルデヒドによるDNA損傷と転写障害- (2022)
  • Author(s): 荻朋男
  • Organizer: 日本人類遺伝学会第67回大会シンポジウム
  • Invited
• [Presentation] Ubiquitination of RNA polymerase II and transcription-coupled repair. (2022)
  • Author(s): Ogi T
  • Organizer: 11th quinquennial conference on DNA repair
  • Int'l Joint Research / Invited
• [Presentation] Ubiquitination of RNA polymerase II and transcription-coupled repair. (2022)
  • Author(s): Ogi T.
  • Organizer: Webinar for the IBS Center for Genomic Integrity
  • Invited
• [Presentation] Digenic inheritanceにより発症するゲノム不安定性疾患の分子病態 -内因性アルデヒドによるDNA損傷と転写障害-. (2022)
  • Author(s): 荻朋男.
  • Organizer: 日本人類遺伝学会第67回大会シンポジウム
  • Invited
• [Presentation] RNA polymerase II のユビキチン化修飾と転写共役修復の制御. (2021)
  • Author(s): 荻朋男.
  • Organizer: 第26回DNA複製・組換え・修復ワークショップ
• [Presentation] RPB1-K1268とUVSSA-K414位でのユビキチン化修飾は転写と共役したヌクレオチド除去修復機構に必要. (2021)
  • Author(s): 中沢由華.
  • Organizer: 日本放射線影響学会第64回大会
• [Presentation] 転写と共役したDNA修復機構にはRNAPIIのユビキチン化修飾が必須である. (2020)
  • Author(s): 中沢由華, 原雄一郎, 岡泰由, 小峯起, Diana van den Heuvel, 郭朝万, 大学保一, 磯野真由, 何予希, 嶋田繭子, 加藤香奈, 賈楠, 橋下悟, 田中都, 祖父江顕, 光武範吏, 菅波孝祥, 増田章男, 大野欽司, 中田慎一郎, 真下知士, 山中宏二, Martijn S. Luijsterburg, 荻朋男.
  • Organizer: 第10回 名古屋大学医学系研究科・生理学研究所合同シンポジウム
• [Presentation] 次世代シークエンスデータ解析の効率を向上させる病原微生物予測パイプラインPATHDETの開発. (2020)
  • Author(s): 堀場千尋, 原 雄一郎, 遠山美穂, 奥村俊彦, 鈴木高子, 鳥居ゆか, 川田潤一, 尾崎紀夫, 荻 朋男, 伊藤嘉規.
  • Organizer: 第52回日本小児感染症学会総会・学術集会
• [Presentation] 「ゲノムの安定性維持機構の破綻による細胞影響から病態理解へ」ストレスの多さはゲノムから: 複製ストレス、転写ストレス、DNAダメージ. (2020)
  • Author(s): 荻朋男, 村井純子.
  • Organizer: 第43回日本分子生物学会年会
  • Invited
• [Remarks] 名古屋大学環境医学研究所HP
  • URL: http://www.riem.nagoya-u.ac.jp/index.html
• [Remarks] 名古屋大学環境医学研究所 発生遺伝分野HP
  • URL: http://www.riem.nagoya-u.ac.jp/4/genetics/index.html
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  • Inventor(s): 荻 朋男、岡 泰由
  • Industrial Property Rights Holder: 東海国立大学機構
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2020-166756
  • Filing Date: 2020
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  • Inventor(s): 荻朋男、中沢由華、小泉誠、小路貴生
  • Industrial Property Rights Holder: 東海国立大学機構、第一三共株式会社
  • Industrial Property Rights Type: 特許
  • Filing Date: 2020
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