| Budget Amount *help |
¥44,460,000 (Direct Cost: ¥34,200,000、Indirect Cost: ¥10,260,000)
Fiscal Year 2024: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Fiscal Year 2023: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2022: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2021: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
Fiscal Year 2020: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Outline of Final Research Achievements |
Bone diseases such as osteoporosis increase the risk of bone fractures and reduce quality of life. Therefore, appropriate prevention and treatment methods are expected to be developed. Forces induced by exercise cause microdamage in bone, which is simultaneously sensed by osteocytes, and the damage is repaired by remodeling. Therefore, it is important to consider damage and repair simultaneously in understanding these complex phenomena.
In this study, based on multiscale mechanics, we mathematically modeled the microdamage accumulation in bone, and simultaneously, the damage sensing and repair process by bone cells. This enables computer simulation of the coupling processes of adaptation and damage repair by remodeling. The developed method contributes to proposing a new method for predicting the coupled effects of exercise and therapeutic drug administration in fracture prevention and treatment.
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