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Functionalization of implant by bio-active coating with ion release and high bonding strength

Research Project

Project/Area Number 20H02448
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 26030:Composite materials and interfaces-related
Research InstitutionTohoku University

Principal Investigator

UEDA Kyosuke  東北大学, 工学研究科, 准教授 (40507901)

Co-Investigator(Kenkyū-buntansha) 成島 尚之  東北大学, 工学研究科, 教授 (20198394)
李 誠鎬  国立研究開発法人産業技術総合研究所, 材料・化学領域, 主任研究員 (20850001)
小笠原 康悦  東北大学, 加齢医学研究所, 教授 (30323603)
金高 弘恭  東北大学, 歯学研究科, 教授 (50292222)
Project Period (FY) 2020-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2023: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2022: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2021: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2020: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Keywords生体内溶解性 / 生体活性ガラス / 骨適合性 / 抗菌性 / RFマグネトロンスパッタリング法 / ゾルゲル・ディップ法 / 密着性 / 擬似体液浸漬 / ゾルゲル法 / ディップコーティング法 / スパッタリング法 / 溶解性評価 / 抗菌性評価 / 溶解性 / 密着力評価 / スパッタリング / 骨形成能向上 / ディップコーティング / 表面処理 / スパッタ / ゾルゲル / チタン / 骨形成能
Outline of Research at the Start

チタン製歯科インプラントの歯根部に求められる優れた骨との適合性と、支台部に求められる抗菌性・軟組織との適合性を達成させつつ、長期間の埋入後には生体内において溶解するバイオアクティブコーティングを創製する。インプラントとの高密着力達成のために、中間層(活性化層)を活用し、抗菌元素、溶解性制御元素および骨形成能向上元素を添加したコーティング膜をゾルゲル法およびスパッタ法にて作製する。

Outline of Final Research Achievements

A coating process of bio-dissolvable bioactive glass with antibacterial elements was developed to provide bone compatibility and antibacterial properties to dental implants made of Ti. The coating films were prepared on the mirror-finished abutment by RF magnetron sputtering and, on the screw-shaped and roughened root by a sol-gel dip method. The coating films had high adhesion, dissolved in simulated body fluid, and the release of antimicrobial elements was detected, indicating antibacterial activity.

Academic Significance and Societal Importance of the Research Achievements

抗菌元素として銅および亜鉛を選択し、生体活性ガラスコーティング膜への導入方法を確立できた。スパッタリング法においてはターゲット作製条件および成膜時のRF出力が、ゾルゲル法では焼成時のチタン基板との反応が、それぞれ影響することを明らかにした。
チタンの有する骨形成能を発揮させるために、生体内における完全溶解という新しい概念を提案し、抗菌性と骨適合性を両立させた生体活性ガラスコーティング設計指針と作製プロセスを確立できた。

Report

(5 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Annual Research Report
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • Research Products

    (65 results)

All 2024 2023 2022 2021 2020 Other

All Int'l Joint Research (2 results) Journal Article (19 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 19 results,  Open Access: 7 results) Presentation (41 results) (of which Int'l Joint Research: 10 results,  Invited: 11 results) Book (3 results)

  • [Int'l Joint Research] Imperial College London(英国)

    • Related Report
      2023 Annual Research Report
  • [Int'l Joint Research] Imperial College London(英国)

    • Related Report
      2022 Annual Research Report
  • [Journal Article] チタンへの抗菌性付与を目指した可視光応答型光触媒TiO2膜の作製と評価2024

    • Author(s)
      上田恭介、成島尚之、古泉隆佑
    • Journal Title

      金属

      Volume: 94 Pages: 233-238

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Niobium and Oxygen Contents on Microstructure and Mechanical Properties of α+β-Type Ti–(5–25)Nb–(0.5–1)O (mass%) Alloys for Biomedical Applications2023

    • Author(s)
      Ueda Kyosuke、Omiya Masahito、Kato Kotaro、Kanetaka Hiroyasu、Narushima Takayuki
    • Journal Title

      MATERIALS TRANSACTIONS

      Volume: 64 Issue: 1 Pages: 138-146

    • DOI

      10.2320/matertrans.MT-MLA2022020

    • ISSN
      1345-9678, 1347-5320
    • Year and Date
      2023-01-01
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Antibacterial Properties of TiO<sub>2</sub> Layers Formed by Au-Sputtering and Thermal Oxidation of Titanium under Visible Light2023

    • Author(s)
      Ueda Takatoshi、Koizumi Ryusuke、Ueda Kyosuke、Ito Koyu、Ogasawara Kouetsu、Kanetaka Hiroyasu、Narushima Takayuki
    • Journal Title

      MATERIALS TRANSACTIONS

      Volume: 64 Issue: 1 Pages: 155-164

    • DOI

      10.2320/matertrans.MT-MLA2022006

    • ISSN
      1345-9678, 1347-5320
    • Year and Date
      2023-01-01
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Visible-light-induced antibacterial activity of carbon and nitrogen co-doped rutile TiO2 films2023

    • Author(s)
      Koizumi Ryusuke、Ueda Kyosuke、Ito Koyu、Ogasawara Kouetsu、Kanetaka Hiroyasu、Mokudai Takayuki、Narushima Takayuki
    • Journal Title

      Thin Solid Films

      Volume: 780 Pages: 139944-139944

    • DOI

      10.1016/j.tsf.2023.139944

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Electronic structure analysis of light-element-doped anatase TiO2 using all-electron GW approach2023

    • Author(s)
      Ishikawa Takashi、Sahara Ryoji、Ohno Kaoru、Ueda Kyosuke、Narushima Takayuki
    • Journal Title

      Computational Materials Science

      Volume: 220 Pages: 112059-112059

    • DOI

      10.1016/j.commatsci.2023.112059

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of the Oxidation and Nitridation of Ti-17 (Ti-5Al-2Sn-2Zr-4Mo-4Cr) Alloys with Added Si under Atmospheric Heating2022

    • Author(s)
      Narushima Takayuki、Suzuki Satoshi、Ueda Kyosuke、Bhattacharya Somesh Kr.、Sahara Ryoji
    • Journal Title

      ISIJ International

      Volume: 62 Issue: 7 Pages: 1512-1521

    • DOI

      10.2355/isijinternational.ISIJINT-2022-053

    • ISSN
      0915-1559, 1347-5460
    • Year and Date
      2022-07-15
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Electronegativity Difference as a Descriptor for the Oxidation-Inhibiting Effect of the Alloying Element during the Early Stages of Titanium Oxidation2022

    • Author(s)
      Kohli Kanika、Bhattacharya Somesh Kr.、Ueda Kyosuke、Narushima Takayuki、Sahara Ryoji、Ghosh Prasenjit
    • Journal Title

      Langmuir

      Volume: 38 Issue: 4 Pages: 1448-1457

    • DOI

      10.1021/acs.langmuir.1c02633

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Flexible and Tough Superelastic Co-Cr Alloys for Biomedical Applications2022

    • Author(s)
      Odaira Takumi、Xu Sheng、Hirata Kenji、Xu Xiao、Omori Toshihiro、Ueki Kosuke、Ueda Kyosuke、Narushima Takayuki、Nagasako Makoto、Harjo Stefanus、Kawasaki Takuro、Bodnarova Lucie、Sedlak Petr、Seiner Hanus、Kainuma Ryosuke
    • Journal Title

      Advanced Materials

      Volume: 34 Issue: 27 Pages: 2202305-2202305

    • DOI

      10.1002/adma.202202305

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Amorphous Calcium Phosphate Coatings2022

    • Author(s)
      Ueda Kyosuke、Narushima Takayuki
    • Journal Title

      Phosphate and borate bioactive glasses

      Volume: 0 Pages: 114-133

    • DOI

      10.1039/9781839164750-00114

    • ISBN
      9781839161643, 9781839164767, 9781839164750
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Precursor Deficiency Induced Ca/P Ratio on Antibacterial and Osteoblast Adhesion Properties of Ag-Incorporated Hydroxyapatite: Reducing Ag Toxicity2021

    • Author(s)
      Gokcekaya Ozkan、Ergun Celaletdin、Webster Thomas J.、Bahadir Abdurrahman、Ueda Kyosuke、Narushima Takayuki、Nakano Takayoshi
    • Journal Title

      Materials

      Volume: 14 Issue: 12 Pages: 3158-3158

    • DOI

      10.3390/ma14123158

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Formation of carbon-added anatase-rich TiO2 layers on titanium and their antibacterial properties in visible light2021

    • Author(s)
      Ueda Takatoshi、Sato Naoki、Koizumi Ryusuke、Ueda Kyosuke、Ito Koyu、Ogasawara Kouetsu、Narushima Takayuki
    • Journal Title

      Dental Materials

      Volume: 37 Issue: 2 Pages: e37-e46

    • DOI

      10.1016/j.dental.2020.10.009

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] チタン合金の抗菌化表面処理2021

    • Author(s)
      成島尚之, 上田恭介, 古泉隆佑
    • Journal Title

      表面技術

      Volume: 72 Pages: 616-621

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antibacterial Functionalization of Ti-based Biomaterials Based on the Understanding of the Inactivation Mechanisms of Bacteria via Photocatalytic Activity of Titanium Oxide: Visible-light Responsive Reaction of Titanium Oxide Coating2020

    • Author(s)
      Ueda Kyosuke、Ueda Takatoshi、Narushima Takayuki
    • Journal Title

      Materia Japan

      Volume: 59 Issue: 11 Pages: 612-617

    • DOI

      10.2320/materia.59.612

    • NAID

      130007933504

    • ISSN
      1340-2625, 1884-5843
    • Year and Date
      2020-11-01
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Using HAADF-STEM for atomic-scale evaluation of incorporation of antibacterial Ag atoms in a β-tricalcium phosphate structure2020

    • Author(s)
      Gokcekaya Ozkan、Ueda Kyosuke、Narushima Takayuki、Nakano Takayoshi
    • Journal Title

      Nanoscale

      Volume: 12 Issue: 31 Pages: 16596-16604

    • DOI

      10.1039/d0nr04208k

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Crystallographic orientation control of pure chromium via laser powder bed fusion and improved high temperature oxidation resistance2020

    • Author(s)
      Gokcekaya Ozkan、Hayashi Naohiro、Ishimoto Takuya、Ueda Kyosuke、Narushima Takayuki、Nakano Takayoshi
    • Journal Title

      Additive Manufacturing

      Volume: 36 Pages: 101624-101624

    • DOI

      10.1016/j.addma.2020.101624

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fabrication of Ag and Ta co-doped amorphous calcium phosphate coating films by radiofrequency magnetron sputtering and their antibacterial activity2020

    • Author(s)
      J. Wu, K. Ueda and T. Narushima
    • Journal Title

      Mater. Sci. Eng. C

      Volume: 109 Pages: 110599-110599

    • DOI

      10.1016/j.msec.2019.110599

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fabrication and bioresorbability of Ag- and Ta-containing amorphous calcium phosphate films formed on titanium substrates by RF magnetron sputtering2020

    • Author(s)
      Wu Jun、Ueda Kyosuke、Narushima Takayuki
    • Journal Title

      MATEC Web of Conferences

      Volume: 321 Pages: 05007-05007

    • DOI

      10.1051/matecconf/202032105007

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 非晶質リン酸カルシウムの生体内溶解性制御とAg担体として利用したチタンへの抗菌性付与2020

    • Author(s)
      上田恭介、成島尚之
    • Journal Title

      バイオマテリアル

      Volume: 38 Pages: 242-247

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 熱酸化法によるTi-Au合金へのチタニアコーティング膜の作製とその可視光応答光触媒活性による抗菌機能化2020

    • Author(s)
      上田恭介、上田隆統志、成島尚之
    • Journal Title

      セラミックス

      Volume: 55 Pages: 146-149

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Presentation] Release of Ag ions from calcium phosphate bio-ceramics to achieve antibacterial activity2024

    • Author(s)
      Kyosuke Ueda
    • Organizer
      International Seminar in IISER Pune
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] バイオセラミックスを利用した金属系材料の表面創製および血管治療用合金開発・プロセス構築に関する研究2024

    • Author(s)
      上田恭介
    • Organizer
      日本金属学会 2024年春期講演(第174回)大会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] Citric acid-assisted sol-gel synthesis of 13-93B3 borate glass2024

    • Author(s)
      JunRey Sullano Lincuna, Kyosuke Ueda, Takayuki Narushima
    • Organizer
      日本金属学会 2024年春期講演(第174回)大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Synthesis of bioactive glass layers on NaOH-treated Ti using sol-gel dip-coating process2023

    • Author(s)
      Kyosuke Ueda, Samuel Alexander, Takayuki Narushima, Julian Jones
    • Organizer
      International Conference on PROCESSING & MANUFACTURING OF ADVANCED MATERIALS, THERMEC’2023
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 生体用セラミックスを用いたインプラントへの機能付与2023

    • Author(s)
      上田恭介
    • Organizer
      東北大学グリーン未来創造機構東北大学グリーンゴールズパートナー 第5回グリーンゴールズ研究会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] ドライプロセスによるチタンの抗菌機能化表面処理2023

    • Author(s)
      上田恭介、成島尚之
    • Organizer
      日本材料学会 第70回生体・医療材料部門委員会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] Synthesis of tantalum- and silver-codoped SiO2-CaO-P2O5 bioactive glasses by the sol-gel method2023

    • Author(s)
      Takuro Masuda, Kyosuke Ueda, Takayuki Narushima
    • Organizer
      Biomaterials International 2023
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ゾルゲル法によるAg, Ta含有SiO2-CaO-P2O5系生体活性ガラスの作製とその溶解性評価2023

    • Author(s)
      増田拓朗、上田恭介、成島尚之
    • Organizer
      2023年度東北大学金属材料研究所共同研究ワークショップ・日本バイオマテリアル学会東北ブロック交流会「東北から若手・中堅研究者が語るバイオマテリアルの将来」
    • Related Report
      2023 Annual Research Report
  • [Presentation] Sol-gel synthesis and characterization of 1393-B3 borate glass2023

    • Author(s)
      Lincuna JunRey Sullano, 上田恭介、成島尚之
    • Organizer
      第6回日本金属学会第7分野講演会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 新型コロナウイルススパイクタンパク質の不活化評価法の確立2023

    • Author(s)
      古泉隆佑、井越翔太、上田恭介、伊藤甲雄、小笠原康悦、成島尚之
    • Organizer
      日本金属学会2023年春期(第172回)講演大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 計算材料科学によるチタン表面酸化に及ぼす合金元素の影響評価2023

    • Author(s)
      佐原亮二、K. Kohli、S. Kr. Bhattacharya、P. Ghosh、上田恭介、成島尚之
    • Organizer
      日本金属学会2023年春期(第172回)講演大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] NaOH処理チタン表面へのゾルゲル・ディップ法による生体活性ガラス膜コーティング2023

    • Author(s)
      上田恭介、Alexander M. Samuel、Julian Jones、成島尚之
    • Organizer
      日本金属学会2023年春期(第172回)講演大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 二段階熱酸化法による炭素・窒素共添加TiO2膜の作製および可視光照射下における抗菌性評価2023

    • Author(s)
      上田恭介、古泉隆佑、伊藤甲雄、小笠原康悦、金髙弘恭、目代貴之、成島尚之
    • Organizer
      国際・産学連携インヴァースイノベーション材料創出プロジェクト-DEJI?MAプロジェクト-Design & Engineering by Joint Inverse Innovation for Materials Architecture(6大学連携プロジェクト)第1回公開討論会
    • Related Report
      2022 Annual Research Report
  • [Presentation] TiO2膜の光触媒活性を利用したチタン表面の抗菌機能化2022

    • Author(s)
      成島 尚之
    • Organizer
      日本金属学会2022年秋期(第171回)講演大会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 酸素に着目したチタンの低コスト・高機能化2022

    • Author(s)
      上田 恭介
    • Organizer
      第2回日本チタン学会講演大会(2022年度)
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Effect of carbon contents on the microstructure of Co-Cr-W-Ni alloys for stent applications2022

    • Author(s)
      Kyosuke Ueda, Sukma Suci Friandani, Takayuki Narushima
    • Organizer
      Interface Summer Seminar 2022, The 17th International Workshop on Biomaterials in Interface Science
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Microstructures of carbon-added Co-Cr-W-Ni alloys for stent application2022

    • Author(s)
      Sukma Suci Friandani, Kyosuke Ueda, Takayuki Narushima
    • Organizer
      The 6th Symposium for the Core Research Clusters for Materials Science and Spintronics, and the 5th Symposium on International Joint Graduate Program in Materials Science
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 二段階熱酸化法によりチタン合金上に作製した可視光応答型炭素含有アナターゼ型TiO2膜の抗菌性評価2022

    • Author(s)
      上田恭介、成島尚之
    • Organizer
      令和4年度第79回日本歯科理工学会学術講演会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 光触媒活性TiO2膜の抗菌性に及ぼす可視光照射条件の影響2022

    • Author(s)
      古泉隆佑、上田恭介、伊藤甲雄、小笠原康悦、成島尚之
    • Organizer
      日本金属学会2022年秋期(第171回)講演大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 全電子混合基底法GW計算による軽元素添加TiO2の電子状態計算2022

    • Author(s)
      佐原亮二、石川立、大野かおる、上田恭介、成島尚之
    • Organizer
      日本金属学会2022年秋期(第171回)講演大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 希土類元素添加によるNiTiの非金属介在物制御2022

    • Author(s)
      上田恭介、柴﨑大侑、山下史祥、成島尚之
    • Organizer
      日本金属学会2022年秋期(第171回)講演大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Preparation of bioactive glass layers on NaOH-treated Ti substrates via sol-gel dip coating method2022

    • Author(s)
      Alexander Samuel, Kyosuke Ueda, Takayuki Narushima
    • Organizer
      2022年度東北大学金属材料研究所共同研究ワークショップ・日本バイオマテリアル学会東北ブロック講演会「臨床応用へ向けたバイオマテリアルサイエンス」
    • Related Report
      2022 Annual Research Report
  • [Presentation] 新型コロナウイルススパイクタンパク質の定量方法確立2022

    • Author(s)
      井越翔太、古泉隆佑、上田恭介、伊藤甲雄、小笠原康悦、成島尚之
    • Organizer
      2022年度東北大学金属材料研究所共同研究ワークショップ・日本バイオマテリアル学会東北ブロック講演会「臨床応用へ向けたバイオマテリアルサイエンス」
    • Related Report
      2022 Annual Research Report
  • [Presentation] 生体用金属・セラミックス系材料の生体外評価の現状と課題2022

    • Author(s)
      上田恭介
    • Organizer
      日本金属学会第170回大会(2022年春期)
    • Related Report
      2021 Annual Research Report
  • [Presentation] 二段階法により作製したTiO2膜の構造および光触媒活性に及ぼす酸化処理条件の影響2022

    • Author(s)
      古泉隆佑、上田恭介、伊藤甲雄、小笠原康悦、成島尚之
    • Organizer
      日本金属学会第170回大会(2022年春期)
    • Related Report
      2021 Annual Research Report
  • [Presentation] チタンの表面処理による抗菌機能化2021

    • Author(s)
      成島尚之
    • Organizer
      2021年度東北大学金属材料研究所共同研究ワークショップ・日本バイオマテリアル学会東北ブロック講演会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Fabrication of Ag-doped amorphous calcium phosphate coating films by RF magnetron sputtering and their antibacterial activity2021

    • Author(s)
      K. Ueda, J. Wu, K. Ito, K. Ogasawara, H. Kanetaka, T. Narushima
    • Organizer
      International Conference on Processing & Manufacturing of Advanced Materials (THERMEC’ 2021)
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Functionalization of the dissolution of amorphous calcium phosphate coatings2021

    • Author(s)
      K. Ueda, T. Narushima
    • Organizer
      The 43rd The Japanese Society for Biomaterials, International Year of Glass (IYOG) 2022 Commemorative Symposium "Biomaterials and Glass Science"
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] チタンの生体応用に向けた表面および組織制御プロセスの開発2021

    • Author(s)
      上田恭介、成島尚之
    • Organizer
      軽金属学会70周年記念 東北支部講演会
    • Related Report
      2021 Annual Research Report
  • [Presentation] チタン表面に作製した炭素含有TiO2膜の短時間可視光照射条件における抗菌性評価2021

    • Author(s)
      古泉隆祐、島田啓太、上田恭介、伊藤甲雄、小笠原康悦、古谷真衣子、金髙弘恭、成島尚之
    • Organizer
      日本金属学会第169回大会(2021年秋期)
    • Related Report
      2021 Annual Research Report
  • [Presentation] 真空蒸留法により作製したMg-Zn合金の擬似体液中における表面反応2021

    • Author(s)
      上田恭介、徳永悠介、成島尚之、井上誠
    • Organizer
      日本金属学会第169回大会(2021年秋期)
    • Related Report
      2021 Annual Research Report
  • [Presentation] チタンの二段階熱酸化法による可視光応答型TiO2膜の作製とその抗菌性評価2021

    • Author(s)
      上田恭介、古泉隆佑、成島尚之
    • Organizer
      第9回日本チタン協会「チタン研究者・技術者研究交流会」、第1回日本チタン学会講演大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Ag, Ta共添加非晶質リン酸カルシウム膜からのAgイオン放出制御と抗菌性2021

    • Author(s)
      上田恭介、Wu Jun、伊藤甲雄、小笠原康悦、古谷真衣子、金髙弘恭、成島尚之
    • Organizer
      日本金属学会第168回大会(2021年春期)
    • Related Report
      2020 Annual Research Report
  • [Presentation] 二段階熱酸化により作製した窒素含有TiO2膜の可視光照射誘起抗菌性および細胞毒性評価2021

    • Author(s)
      古泉隆祐、島田啓太、上田恭介、伊藤甲雄、小笠原康悦、古谷真衣子、金髙弘恭、成島尚之
    • Organizer
      日本金属学会第168回大会(2021年春期)
    • Related Report
      2020 Annual Research Report
  • [Presentation] Antibacterial activity of Ag-Ta co-containing amorphous calcium phosphate coating films2020

    • Author(s)
      K. Ueda, J. Wu, K. Ito, K. Ogasawara, H. Kanetaka, T. Narushima
    • Organizer
      11th World Biomaterials Congress
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of Ta addition on the antibacterial activity and cytotoxicity of Ag-containing amorphous calcium phosphate coating film2020

    • Author(s)
      K. Ueda, J. Wu, K. Ito, K. Ogasawara, M. Furuya, K. Yokota, H. Kanetaka, T. Narushima
    • Organizer
      International Joint Symposium 2020, The 15th International Workshop on Biomaterials in Interface Science, The 11th Symposium on Innovative Dental-Engineering Alliance (IDEA)
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Visible-light-induced antibacterial activity of TiO2 layer formed by the two-step thermal oxidation2020

    • Author(s)
      R. Koizumi, K. Ueda, K. Ito, K. Ogasawara, T. Narushima
    • Organizer
      The 4th Symposium for The Core Research Cluster for Materials Science and the 3rd Symposium on International Joint Graduate Program in Materials Science
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 金属系材料の生体応用に向けた表面および組織創製プロセスの開発2020

    • Author(s)
      上田恭介
    • Organizer
      日本金属学会第167回大会(2020年秋期)
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] チタン表面に作製した炭素・窒素含有TiO2膜の可視光照射下における抗菌能2020

    • Author(s)
      古泉隆祐、上田隆統志、上田恭介、伊藤甲雄、小笠原康悦、成島尚之
    • Organizer
      日本金属学会第167回大会(2020年秋期)
    • Related Report
      2020 Annual Research Report
  • [Presentation] 2段階熱酸化法による窒素添加酸化チタン膜の作製とその抗菌性評価2020

    • Author(s)
      上田恭介、上田隆統志、佐藤直生、古泉隆祐、目代貴之、伊藤甲雄、小笠原康悦、金髙弘恭、成島尚之
    • Organizer
      学際・国際的人材養成ライフイノベーションマテリアル創製共同研究プロジェクト 第5回公開討論会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Evaluation of long-term antibacterial activity of Ag-containing amorphous calcium phosphate films with various Ta contents2020

    • Author(s)
      Jun Wu, 上田恭介、伊藤甲雄、小笠原康悦、金髙弘恭、成島尚之
    • Organizer
      第3回 日本金属学会第7分野講演会「金属系バイオマテリアルサイエンスの新展開(III)」
    • Related Report
      2020 Annual Research Report
  • [Book] チタンの基礎と応用2023

    • Author(s)
      新家光雄、池田勝彦、成島尚之、中野貴由、細田秀樹
    • Total Pages
      464
    • Publisher
      内田老鶴圃
    • ISBN
      9784753651122
    • Related Report
      2022 Annual Research Report
  • [Book] 製品利用に向けたバイオマテリアル開発の基本事項と注意点―材料の特徴・材料劣化・表面解析・安全性試験・ニーズ収集―2022

    • Author(s)
      塙 隆夫、菊池 正紀、田中 賢
    • Total Pages
      306
    • Publisher
      情報機構
    • ISBN
      9784865022360
    • Related Report
      2022 Annual Research Report
  • [Book] Phosphate and Borate Bioactive Glasses2022

    • Author(s)
      K. Ueda and T. Narushima
    • Total Pages
      300
    • Publisher
      Royal Society of Chemistry
    • ISBN
      9781839161643
    • Related Report
      2021 Annual Research Report

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Published: 2020-04-28   Modified: 2025-01-30  

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