| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2023: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2022: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2021: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2020: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
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| Outline of Final Research Achievements |
This study, aiming to advance the industrial freeze-drying process, focused on investigating the correlation between the quality of bioproducts and the state of products during freeze-drying, and on developing measurement techniques using microwave resonance spectra. We analyzed the process of freeze-dried matrices changing their shape during the drying process and predicted the occurrence of micro-collapses by finite element analysis. We also investigated the phase relationship between the residual activity of the bioproduct and the degree of occurrence of micro-collapses using model materials (i.e. enzyme). In order to determine the state of the product during the freeze-drying process from the microwave resonance spectrum, we developed a prototype freeze-drying system that implements this measurement system and developed a technique for monitoring the progress of drying.
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