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Investigation of nanomaterial design for preferential tumor accumulation

Research Project

Project/Area Number 20H02584
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 28040:Nanobioscience-related
Research InstitutionKyoto University

Principal Investigator

Komatsu Naoki  京都大学, 人間・環境学研究科, 教授 (30253008)

Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2022: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2021: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2020: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Keywordsナノ粒子 / ポリグリセロール / 癌 / 腫瘍 / nanoparticle / cancer / functionalization / therapy / imaging / polyglycerol / タンパク質コロナ / ステルス効果
Outline of Research at the Start

がん治療においてナノ粒子を用いることは、腫瘍への選択的な集積により副作用を抑え、治療効果を高めると信じられてきたが、ごく最近、投与量に対して平均 0.7% のナノ粒子しか腫瘍に到達していないという数字が発表された。一方、申請者らはごく最近、表面がポリグリセロールで修飾された蛍光ナノ粒子を用いた生体腫瘍イメージングにおいて、ナノ粒子が腫瘍へ選択的に集積することを確認した。本研究では、まず、この蛍光ナノ粒子が示した優れたステルス性について検討を行う。次に、ナノ粒子表面に形成されるタンパク質コロナに焦点を当てて解明をはかる。最終的には、がんの診断・治療におけるナノ粒子の設計指針の再構築を目指す。

Outline of Final Research Achievements

First, protein corona formation was examined for nanodiamond (ND) and magnetic iron oxide nanoparticles (SPION) coated with polyglycerol (PG) and further modified with various functional groups such as carboxy groups, amino groups, sulfonate, and phosphonium. The results showed that negatively charged groups such as carboxy one did not produce protein corona, while positively charged amino groups produced protein corona. The cellular uptake is found to be facilitated proportionally by the amount of corona proteins. Therefore, it is important to control the formation of protein corona by using negatively charged functional groups for tumor-selective accumulation of polyglycerol-functionalized nanoparticles.

Academic Significance and Societal Importance of the Research Achievements

ポリグリセロール修飾ナノ粒子の腫瘍選択的集積の原因が明らかになれば、それがナノ製剤の新たな設計指針となり、ナノ医療の分野にパラダイムシフトを起こすことが可能である。一方。この研究成果は、癌の早期発見や治療にも繋がり、社会的にも経済的にも大きなインパクトがあると考えている。

Report

(3 results)
  • 2022 Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • Research Products

    (6 results)

All 2022 2021 2020

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (2 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Organic chemistry for nanodiamond: Controlled functionalization, quantitative characterization and structure-property relationships2022

    • Author(s)
      Yajuan Zou, Masahiro Nishikawa and Naoki Komatsu
    • Journal Title

      Carbon Reports

      Volume: 1 Issue: 2 Pages: 70-78

    • DOI

      10.7209/carbon.010204

    • ISSN
      2436-5831
    • Year and Date
      2022-06-01
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Probing the role of charged functional groups on nanoparticles grafted with polyglycerol in protein adsorption and cellular uptake2022

    • Author(s)
      Yajuan Zou,Shinji Ito,Masazumi Fujiwara,Naoki Komatsu
    • Journal Title

      Advanced Functional Materials

      Volume: na Issue: 22 Pages: 2111077-2111077

    • DOI

      10.1002/adfm.202111077

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Effect of Protein Corona on Mitochondrial Targeting Ability and Cytotoxicity of Triphenylphosphonium Conjugated with Polyglycerol-Functionalized Nanodiamond2021

    • Author(s)
      Zou Yajuan、Nishikawa Masahiro、Kang Heon Gyu、Cheng Guoqing、Wang Wei、Wang Yuquan、Komatsu Naoki
    • Journal Title

      Molecular Pharmaceutics

      Volume: 18 Issue: 7 Pages: 2823-2832

    • DOI

      10.1021/acs.molpharmaceut.1c00188

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Presentation] 化学修飾ナノ材料を用いた腫瘍標的セラノスティクス2021

    • Author(s)
      小松直樹
    • Organizer
      第72回産学連携化学フォーラム
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Polyglycerol Grafted Nanodiamond Avoids Protein Corona Formation, Evades Macrophage Uptake and Images Tumor Fluorescently2020

    • Author(s)
      小松直樹
    • Organizer
      Virtual MRS Spring/Fall Meeting (Symposium NM01)
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Patent(Industrial Property Rights)] 修飾炭化ホウ素粒子及びそれを含む中性子捕捉療法用薬剤2021

    • Inventor(s)
      小松直樹、鈴木実
    • Industrial Property Rights Holder
      国立大学法人京都大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2021-122588
    • Filing Date
      2021
    • Related Report
      2021 Annual Research Report

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Published: 2020-04-28   Modified: 2024-01-30  

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