| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2023: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2022: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2021: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2020: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Outline of Final Research Achievements |
RNaseH-dependent antisense oligonucleotides (ASOs) are therapeutic agents targeting RNA. However, safety concerns such as off-target effects hinder their broad use. In this study, we identified important interactions between RNaseH and ASO complexes, aiming to avoid off-target effects by utilizing strain through rigidifications to non-standard sugar moieties and relaxation through systematic methylene insertions. These findings have enabled the development of a methodology that selectively degrades only the perfectly matched duplex.
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