| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2022: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2021: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2020: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
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| Outline of Final Research Achievements |
In this study, we aimed to develop a chiral amplification system utilizing serinol nucleic acid (SNA). First, we prepared a one-dimensional nano structure by hybridizing achiral SNA strands. When chiral nucleic acid was added, CD intensity drastically increased. Thus, chiral amplification system triggered by duplex formation was successfully developed for the first time. Then we modified SNA nano structures with pyrene. The structure expressed circularly polarized luminescence (CPL) upon the addition of chiral nucleic acids. We also succeeded to develop a chiral amplification system triggered by DNA.
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