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Development and utilization of the model system of disease cell for quantitative analysis of nucleic acid structures in cells

Research Project

Project/Area Number 20H02864
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 37010:Bio-related chemistry
Research InstitutionKonan University

Principal Investigator

Tateishi-Karimata Hisae  甲南大学, 先端生命工学研究所, 准教授 (20593495)

Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2022: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2021: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2020: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Keywords核酸構造 / 擬似細胞内環境 / 相分離 / 定量的解析 / 神経変性疾患 / 細胞モデル系 / 細胞模倣実験系 / リピートRNA / 細胞内環境評価系 / 液滴 / 熱力学的解析 / 細胞内分子環境評価系
Outline of Research at the Start

液滴は細胞内の環境によって、形成、消失を繰り返し、細胞内の重要な反応を促進または抑制する効果をもつ。近年、神経変性疾患の細胞毒性を示すペプチドやタンパク質などが細胞内で液滴を形成することが見出され、疾患と関連性が注目されている。本研究では、疾患の進行に伴う細胞内の環境変化が核酸の構造に及ぼす影響に注目し、液滴の関わる生体反応の新たな調節機構の解明と、その知見を活用した生体反応制御技術の開発を目指す。

Outline of Final Research Achievements

Droplets formed in neurodegenerative disease cells contain RNA and peptides with repeat sequences and should exhibit cytotoxicity although the detailed mechanism of droplet formation has not been clarified. In this study, to elucidate the mechanism of droplet formation, we constructed an intracellular molecular environment evaluation system and analyzed the effects of the molecular environment on the structure of nucleic acids and droplet formation. The results indicated that the formation of RNA G-quadruplexeschanged depending on surrounding conditions and showed key roles for droplet formation. Interestingly, the droplet formation was accelerated with increasing the G-quadruplex stability. Our results suggested that changes in the intracellular environment associated with disease progression may alter the structure of nucleic acids and regulate the formation of droplets.

Academic Significance and Societal Importance of the Research Achievements

核酸の構造は、周辺環境に応答して変化し、遺伝子発現に関わる反応の変異を誘起させる可能性がある。本研究では、核酸の構造が生命現象を制御する機能をもつことを示す一例として、神経変性疾患に関わるRNA構造に焦点をあてた。その結果、細胞毒性に関わる液滴形成を制御する核酸構造を特定することができた。本知見は、細胞毒性を示す凝集体形成を阻害する化合物の合理的な分子設計に有効である。
さらに、本研究で構築した細胞モデル系は、核酸相互作用だけでなく、実細胞内での薬剤と解析対象分子の結合性評価等も簡便に行うことができる。そのため、医療、診断、創薬など実社会に貢献する幅広い応用分野への研究展開が期待される。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • Research Products

    (72 results)

All 2023 2022 2021 2020 Other

All Int'l Joint Research (6 results) Journal Article (16 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 15 results,  Open Access: 11 results) Presentation (44 results) (of which Int'l Joint Research: 14 results,  Invited: 8 results) Book (2 results) Remarks (3 results) Patent(Industrial Property Rights) (1 results)

  • [Int'l Joint Research] 南京農業大学(中国)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] 国立NMRセンター(スロベニア)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] 国立NMRセンター(スロベニア)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] コルカタ大学(インド)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] Slovenian NMR Centre(スロベニア)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] Changchun University of Chinese Medicine(中国)

    • Related Report
      2020 Annual Research Report
  • [Journal Article] Simple and fast screening for structure-selective G-quadruplex ligands2023

    • Author(s)
      Y. Hashimoto, Y. Imagawa, K. Nagano, R. Maeda, N. N.agahama, T. Torii, N. Kinoshita, N. Takamiya, K. Kawauchi, H. Tateishi-Karimata, N. Sugimoto and D. Miyoshi
    • Journal Title

      Chem. Commun.

      Volume: 59 Issue: 33 Pages: 4891-4894

    • DOI

      10.1039/d3cc00556a

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] DNA methylation is regulated by both the stability and topology of G-quadruplex2022

    • Author(s)
      Matsumoto Saki、Tateishi-Karimata Hisae、Sugimoto Naoki
    • Journal Title

      Chemical Communications

      Volume: 58 Issue: 89 Pages: 12459-12462

    • DOI

      10.1039/d2cc04383a

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Controlling liquid-liquid phase separation of G-quadruplex-forming RNAs in a sequence-specific manner2022

    • Author(s)
      Tsuruta Mitsuki、Torii Takeru、Kohata Kazuki、Kawauchi Keiko、Tateishi-Karimata Hisae、Sugimoto Naoki、Miyoshi Daisuke
    • Journal Title

      Chemical Communications

      Volume: 58 Issue: 93 Pages: 12931-12934

    • DOI

      10.1039/d2cc04366a

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High-temperature adaptation of an OsNRT2.3 allele is thermoregulated by small RNAs2022

    • Author(s)
      Zhang Yong、Tateishi-Karimata Hisae、Endoh Tamaki、Jin Qiongli、Li Kexin、Fan Xiaoru、Ma Yingjun、Gao Limin、Lu Haiyan、Wang Zhiye、Cho Art E.、Yao Xuefeng、Liu Chunming、Sugimoto Naoki、Guo Shiwei、Fu Xiangdong、Shen Qirong、Xu Guohua、Herrera-Estrella Luis Rafael、Fan Xiaorong
    • Journal Title

      Science Advances

      Volume: 8 Issue: 47

    • DOI

      10.1126/sciadv.adc9785

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Nearest-neighbor parameters for the prediction of RNA duplex stability in diverse in vitro and cellular-like crowding conditions2022

    • Author(s)
      S. Ghosh, S. Takahashi, D. Banerjee, T. Ohyama, T. Endoh, H. Tateishi-Karimata, and N. Sugimoto
    • Journal Title

      Nucleic Acids Res.,

      Volume: 51 Issue: 9 Pages: 4101-4111

    • DOI

      10.1093/nar/gkad020

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Chemical Modulation of DNA Replication along G-Quadruplex Based on Topology-Dependent Ligand Binding2021

    • Author(s)
      S. Takahashi, A. Kotar, H. Tateishi-Karimata, S. Bhowmik, Z.-F. Wang, T.-C. Chang, S, Sato, S. Takenaka, J. Plavec, and N. Sugimoto
    • Journal Title

      J. Am. Chem. Soc.

      Volume: 143 Issue: 40 Pages: 16458-16469

    • DOI

      10.1021/jacs.1c05468

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Intramolecular G-quadruplex-hairpin loop structure competition of a GC-rich exon region in the TMPRSS2 gene2021

    • Author(s)
      W. Sugimoto, N. Kinoshita, M. Nakata, T. Ohyama, H. Tateishi-Karimata, T. Nishikata, N. Sugimoto, D. Miyoshi, and K. Kawauchi
    • Journal Title

      Chem. Commun.

      Volume: 58 Issue: 1 Pages: 48-51

    • DOI

      10.1039/d1cc05523b

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of DNA modifications on the transition bet and non-canoncial DNA stransures in CpG islands during senescence2021

    • Author(s)
      S. Matsumoto, H. Tateishi-Karimata, T. Ohyama, and N. Sugimoto
    • Journal Title

      RSC Adv.

      Volume: 11 Issue: 59 Pages: 37205-37217

    • DOI

      10.1039/d1ra07201c

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Roles of non-canonical structures of nucleic acids in cancer and neurodegenerative diseases2021

    • Author(s)
      H. Tateishi-Karimata and N. Sugimoto
    • Journal Title

      Nucleic Acids Res

      Volume: 49 Issue: 14 Pages: 7839-7855

    • DOI

      10.1093/nar/gkab580

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Chemical Biology of Double Helical and Non-Double Helical Nucleic Acids: “To <i>B</i> or Not To <i>B</i>, That Is the Question”2021

    • Author(s)
      Sugimoto Naoki、Endoh Tamaki、Takahashi Shuntaro、Tateishi-Karimata Hisae
    • Journal Title

      Bulletin of the Chemical Society of Japan

      Volume: 94 Issue: 7 Pages: 1970-1998

    • DOI

      10.1246/bcsj.20210131

    • NAID

      130008076882

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 第1章フロントランナーに聞く「令和の時代も進化を続ける核酸化学」2021

    • Author(s)
      神谷 真子、建石 寿枝、永次 史、山吉 麻子、杉本 直己
    • Journal Title

      CSJカレントレビュー「進化を続ける核酸化学―ゲノム編集、非二重+RC[-1]+RC

      Volume: 41 Pages: 2-13

    • Related Report
      2021 Annual Research Report
  • [Journal Article] Thrombin binding aptamer G-quadruplex stabilized by pyrene-modified nucleotides2020

    • Author(s)
      Kovacic Matic、Podbevsek Peter、Tateishi-Karimata Hisae、Takahashi Shuntaro、Sugimoto Naoki、Plavec Janez
    • Journal Title

      Nucleic Acids Research

      Volume: 48 Issue: 7 Pages: 3975-3986

    • DOI

      10.1093/nar/gkaa118

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] RNA G-Quadruplexes Facilitate RNA Accumulation in G-Rich Repeat Expansions2020

    • Author(s)
      Teng Ye、Tateishi-Karimata Hisae、Sugimoto Naoki
    • Journal Title

      Biochemistry

      Volume: 59 Issue: 21 Pages: 1961-2040

    • DOI

      10.1021/acs.biochem.0c00130

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Nearest-neighbor parameters for predicting DNA duplex stability in diverse molecular crowding conditions2020

    • Author(s)
      S. Ghosh, S. Takahashi, T. Ohyama, T. Endoh, H. Tateishi-Karimata, and N. Sugimoto
    • Journal Title

      Proc. Natl. Acad. Sci. USA.

      Volume: 117 Issue: 25 Pages: 14194-14201

    • DOI

      10.1073/pnas.1920886117

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of morecular crowding on the stability of RNA G-quadruplexes with various numbers of quartets and lengths of loops2020

    • Author(s)
      S. Matsumoto, H. Tateishi-Karimata, S. Takahashi, T. Ohyama, and N. Sugimoto
    • Journal Title

      Biochemistry

      Volume: 59 Issue: 28 Pages: 2640-2649

    • DOI

      10.1021/acs.biochem.0c00346

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improved nearest-neighbor parameters for the stability of RNA/DNA hybrids under a physiological condition2020

    • Author(s)
      D. Banerjee, H. Tateishi-Karimata, T. Ohyama, S. Ghosh, T. Endoh, S. Takahashi, and N. Sugimoto
    • Journal Title

      Nucleic Acids Res.

      Volume: 48 Issue: 21 Pages: 12042-12054

    • DOI

      10.1093/nar/gkaa572

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Nucleic Acids Chemistry beyond the Watson-Crick Double Helix (83) : Bulge-containing G-quadruplexes is a new target motif to regulate gene expression in therapeutics2023

    • Author(s)
      S. Sarkar, H. Tateishi-Karimata, N. Sugimoto
    • Organizer
      日本化学会第103回春季年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Nucleic Acids Chemistry beyond the Watson-Crick Double Helix (82) : Applications of nearest-neighbor parameters for RNA/DNA hybrid duplexes in the advancement of therapeutics2023

    • Author(s)
      Dipanwita Banerjee, Hisae Tateishi-Karimata, Saptarshi Ghosh, Shuntaro Takahashi, Tatsuya Ohyama, Tamaki Endoh, Maria Toplishek, Marko Trajkovski , Janez Plavec, Naoki Sugimoto
    • Organizer
      日本化学会第103回春季年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Nucleic Acids Chemistry beyond the Watson-Crick Double Helix (81) : Stability prediction of RNA duplexes under various molecular crowding in vitro and in cell2023

    • Author(s)
      Saptarshi Ghosh, Shuntaro Takahashi, Dipanwita Banerjee, Tatsuya Ohyama, Tamaki Endoh, Hisae Tateishi-Karimata, Naoki Sugimoto1
    • Organizer
      日本化学会第103回春季年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 脱ワトソン・クリックの核酸化学 (88): がん細胞内環境変化に応答したC四重らせん構造の形成機構の解明2023

    • Author(s)
      建石 寿枝、川内 敬子、杉本 直己
    • Organizer
      日本化学会第103回春季年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 脱ワトソン・クリックの核酸化学 (85): G4C2 繰り返し配列をもつ RNA 四重鎖とジペプチドの集積メカニズムの解析2023

    • Author(s)
      大山 達也、建石 寿枝、田中 成典、杉本 直己
    • Organizer
      日本化学会第103回春季年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 構造選択的G4リガンドのテロメア長とTERRA発現量に対する効果2023

    • Author(s)
      橋本 佳樹、取井 猛流、木下 菜月、川内 敬子、建石 寿枝、杉本 直己、三好 大輔
    • Organizer
      日本化学会第103回春季年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 核酸構造の定量的解析を基にしたC9orf72由来のリピートRNAとペプチドの相互作用制御法の開発2022

    • Author(s)
      建石寿枝, 松本咲, 大山達也, Ye Teng, 田中成典, 杉本直己
    • Organizer
      日本核酸医薬学会第7回年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Functions of nucleic acids regulated by the intracellular molecular environments2022

    • Author(s)
      H. Tateishi-Karimata, N. Sugimoto
    • Organizer
      India|EMBO Lecture Course: Functional nucleic acids: Recent landscapes and therapeutic applications
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 神経変性疾患に関わるリピートRNAとペプチドの相互作用解析2022

    • Author(s)
      建石 寿枝, 大山達也, 田中成典, 杉本 直己
    • Organizer
      第16回バイオ関連化学シンポジウム
    • Related Report
      2022 Annual Research Report
  • [Presentation] 疾患細胞内における非二重らせん核酸の機能解析2022

    • Author(s)
      建石寿枝
    • Organizer
      大阪大学産業科学研究所 次世代有機化学セミナー
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] DNA methylation depending on stability and topology of G-quadruplex2022

    • Author(s)
      S. Matsumoto, H. Tateishi-Karimata, N. Sugimoto
    • Organizer
      Advances in Noncanonical Nucleic Acids 2022 “ANNA2022”
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Analysis of dynamic behaviors of G-quadruplexes using molecular simulations2022

    • Author(s)
      T. Ohyama, H. Tateishi-Karimata, S. Takahashi, S. Tanaka, N. Sugimoto
    • Organizer
      Advances in Noncanonical Nucleic Acids 2022 “ANNA2022”
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Analysis of the effect of high-pressure on the stability of nucleic acids using molecular dynamics simulations2022

    • Author(s)
      T. Ohyama, S. Takahashi, H. Tateishi-Karimata, S. Tanaka, N. Sugimoto
    • Organizer
      第49回国際核酸化学シンポジウム
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Prediction of RNA duplex stability in physiological crowding conditions based on the nearest-neighbor model2022

    • Author(s)
      S. Ghosh, S. Takahashi, D. Banerjee, T. Ohyama, T. Endoh, H. Tateishi-Karimata, N. Sugimoto
    • Organizer
      第49回国際核酸化学シンポジウム
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] New parameters for accurate prediction of RNA/DNA hybrid duplex stability and their advantage in CRISPR- Cas9 technique2022

    • Author(s)
      D. Banerjee, H. Tateishi-Karimata, T. Ohyama, S. Ghosh, T. Endoh, S. Takahashi, N. Sugimoto
    • Organizer
      第49回国際核酸化学シンポジウム
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The effect of stability and topology of G-quadruplex on DNA methylation2022

    • Author(s)
      S. Matsumoto, H. Tateishi-Karimata, N. Sugimoto
    • Organizer
      第49回国際核酸化学シンポジウム
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Quantitative analysis for G-quadruplex and i-motif formations in malignant cancers2022

    • Author(s)
      H. Tateishi-Karimata, N. Sugimoto
    • Organizer
      第49回国際核酸化学シンポジウム
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 生物種を超えた多元応答機構の解明を目指した核酸構造の解析2022

    • Author(s)
      建石寿枝
    • Organizer
      第95回日本生化学会大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 環境応答性を示す非二重らせん核酸構造のスクリーニング法の構築2022

    • Author(s)
      遠藤 玉樹, 奥田 修二郎, 凌 一葦, 建石 寿枝, 杉本 直己
    • Organizer
      第95回日本生化学会大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] グアニン四重らせん構造による転移因子 LINE?1 の発現抑制2022

    • Author(s)
      月生雅也, 李先民, Yemima Suryani Budirahardja, 鶴田充生, 橋本佳樹, 高宮渚, 木下菜月, 建石寿枝, 杉本直己, 三好大輔, 川内敬子
    • Organizer
      第14回日本女性科学者の会(SJWS)学術会議
    • Related Report
      2022 Annual Research Report
  • [Presentation] 核小体LLPSにおけるrDNA由来G-quadruplexの役割2022

    • Author(s)
      取井 猛流、杉本 渉、建石 寿枝、木下 菜月、鶴田 充生、月生 雅也、村嶋 貴之、西方 敬人、杉本 直己、三好 大輔、川内 敬子
    • Organizer
      第45回日本分子生物学会年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 液-液相分子により形成されるグアニン四重らせん構造集合体の役割2022

    • Author(s)
      川内 敬子、取井 猛流、谷口 慎也、木下 菜月、建石寿枝、杉本 直己、三好 大輔
    • Organizer
      第45回日本分子生物学会年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] グアニン四重らせん構造による転移因子LINE-1の発現制御2022

    • Author(s)
      李 先民, 月生 雅也, Budirahardja Yemima Suryani, 木下 菜月, 谷口 慎也, 橋本 佳樹, 建石 寿枝, 杉本 直己, 三好 大輔, 川内 敬子
    • Organizer
      第45回日本分子生物学会年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] ホヤ卵の胚軸形成におけるRNAのG-quadruplex(G4)の局在2022

    • Author(s)
      鳥居 柊平、後藤 俊志、建石 寿枝、杉本 直己、西方 敬人
    • Organizer
      第45回日本分子生物学会年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 核酸の姿と病気の関わり2022

    • Author(s)
      建石寿枝
    • Organizer
      日本薬学会関西支部市民公開講座
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Nucleic Acids Chemistry beyond the Watson-Crick Double Helix (73):Effect of G-quadruplex stability change on transcriptional repression in cancer cells2022

    • Author(s)
      H. Tateishi-Karimata, K. Kawauchi, T. Ohyama, H. Masaki, A. Natsume, N. Sugimoto
    • Organizer
      日本化学会第102回春季年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Nucleic Acids Chemistry beyond the Watson-Crick Double Helix (74): Effect of DNA modifications on the transition between canonical and non-canonical DNA structures in CpG island2022

    • Author(s)
      S. Matsumoto, H. Tateishi-Karimata, T. Ohyama, N. Sugimoto
    • Organizer
      日本化学会第102回春季年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 核酸二次構造を標的としたドロップレットの分解2022

    • Author(s)
      鶴田 充生, 取井 猛流, 小畠 一起, 川内 敬子, 建石 寿枝, 杉本 直己, 三好 大輔
    • Organizer
      日本化学会第102回春季年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] トポロジー依存的なリガンド結合でグアニン四重鎖のDNA複製を制御する2021

    • Author(s)
      高橋俊太郎, 建石寿枝, 佐藤しのぶ, 竹中繁織, J. Plavec, 杉本直己
    • Organizer
      第15回バイオ関連化学シンポジウム
    • Related Report
      2021 Annual Research Report
  • [Presentation] 神経変性疾患に係るリピートRNAとペプチドの相互作用解析2021

    • Author(s)
      建石寿枝, 大山達也, 田中成典, 杉本直己
    • Organizer
      第15回バイオ関連化学シンポジウム
    • Related Report
      2021 Annual Research Report
  • [Presentation] G-quadruplex formation in cancer cells with different expression level of ion channels2021

    • Author(s)
      H. Tateishi-Karimata, N. Sugimoto
    • Organizer
      第48回国際核酸化学シンポジウム
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Chemical modulation of DNA replication by topology- dependent ligand binding on guanine quadruplexes2021

    • Author(s)
      S. Takahashi, A. Kotar, H. Tateishi-Karimata, S. Bhowmik, Zi-Fu Wang, Ta-Chau Chang, S. Sato, S. Takenaka, J. Plavec, N. Sugimoto
    • Organizer
      第48回国際核酸化学シンポジウム
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Structure-based derivatization of berberine to improve the potency for targeting RNA structures2021

    • Author(s)
      S. Satpathi, T. Endoh, Y. Chen, S. Matsumoto, T. Ohyama, P. Podbev?ek, J. Plavec, K. Onizuka, F. Nagatsugi, N. Sugimoto
    • Organizer
      第21回東北大学多元物質科学研究所研究発表会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Effect of DNA modifications on the changes of DNA structure in CpG islands2021

    • Author(s)
      S. Matsumoto, H. Tateishi-Karimata, O. Tatsuya, N. Sugimoto
    • Organizer
      ICCAES 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Roles of non-canonical DNA structures in cancer cells on mechanism of dimensional response genome2021

    • Author(s)
      H. Tateishi-Karimata, N. Sugimoto
    • Organizer
      ICCAES 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Regulation transcription by DNA structures responsive chemical stimulus in cells2021

    • Author(s)
      H. Tateishi-Karimata, K. Kawauchi, N. Sugimoto
    • Organizer
      Pacifichem2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Liquid-liquid phase separation of G-quadruplexes derived from neurodegenerative disease RNAs2021

    • Author(s)
      D. Miyoshi, M. Tsuruta, K. Kohata, W. Sugimoto, T. Torii, H. Tateishi-Karimata, N. Sugimoto, K. Kawauchi
    • Organizer
      Pacifichem2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Structural alterations in ribosomal DNA under nucleolar stress2021

    • Author(s)
      K. Kawauchi, T. Torii, H. Tateishi-Karimata, N. Sugimoto, T. Nishikata, D. Miyoshi
    • Organizer
      The 44th Annual Meeting of Molecular Biology Society of Japan
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 脱ワトソン・クリックの核酸化学(67): DNA四重らせん構造と転写変異に及ぼすがんの悪性進行に伴う細胞内環境変化の影響2021

    • Author(s)
      建石寿枝, 川内敬子, 大山達也, 杉本直己
    • Organizer
      日本化学会第101回春季年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ワトソン・クリックの核酸化学(69): 神経変性疾患に関連するRNA四重鎖とジペプチドリピートの分子シミュレーションによる相互作用の解析2021

    • Author(s)
      大山達也, 建石寿枝, 田中成典, 杉本直己
    • Organizer
      日本化学会第101回春季年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 神経変性疾患に関わるリピートRNAによる相分離機構の解析2020

    • Author(s)
      建石寿枝, Ye Teng, 大山達也, 田中成典, 杉本直己
    • Organizer
      第14回バイオ関連化学シンポジウム
    • Related Report
      2020 Annual Research Report
  • [Presentation] 異なるGカルテット数とループ長を有するRNAグアニン四重らせんの安定性への分子クラウディングの効果2020

    • Author(s)
      松本咲, 建石寿枝, 高橋俊太郎, 大山達也, 杉本直己
    • Organizer
      第14回バイオ関連化学シンポジウム
    • Related Report
      2020 Annual Research Report
  • [Presentation] Stability prediction of DNA duplexes available under diverse molecular crowding conditions2020

    • Author(s)
      GHOSH Saptarshi, 高橋俊太郎, 大山達也, 遠藤玉樹, 建石寿枝, 杉本直己
    • Organizer
      第14回バイオ関連化学シンポジウム
    • Related Report
      2020 Annual Research Report
  • [Presentation] Development of the prediction method for stability of RNA/DNA hybrids under a physiological condition2020

    • Author(s)
      BANERJEE Dipanwita, 建石寿枝, 大山達也, GHOSH Saptarshi, 遠藤玉樹, 高橋俊太郎, 杉本直己
    • Organizer
      第14回バイオ関連化学シンポジウム
    • Related Report
      2020 Annual Research Report
  • [Book] 第Ⅳ部 生物学的相分離の理論2021

    • Author(s)
      建石寿枝, 杉本直己
    • Total Pages
      416
    • Publisher
      東京化学同人
    • ISBN
      9784807913466
    • Related Report
      2021 Annual Research Report
  • [Book] 核酸科学ハンドブック2020

    • Author(s)
      杉本直己
    • Total Pages
      565
    • Publisher
      講談社
    • ISBN
      9784065207864
    • Related Report
      2020 Annual Research Report
  • [Remarks] 甲南大学先端生命工学研究所ホームページ

    • URL

      https://www.konan-fiber.jp/indexb/

    • Related Report
      2022 Annual Research Report
  • [Remarks] 甲南大学先端生命工学研究所ホームページ

    • URL

      http://www.konan-fiber.jp/indexb/

    • Related Report
      2021 Annual Research Report
  • [Remarks] 甲南大学先端生命工学研究所 ホームページ

    • URL

      http://www.konan-fiber.jp/index.php

    • Related Report
      2020 Annual Research Report
  • [Patent(Industrial Property Rights)] 核酸の立体構造を制御する方法及びその用途、並びに、細胞内分子クラウディング環境を再現するための組成物2022

    • Inventor(s)
      建石 寿枝、高橋 俊太郎、川内 敬子、杉本 直己
    • Industrial Property Rights Holder
      建石 寿枝、高橋 俊太郎、川内 敬子、杉本 直己
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2022-189538
    • Filing Date
      2022
    • Related Report
      2022 Annual Research Report

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Published: 2020-04-28   Modified: 2024-01-30  

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