| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2022: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2021: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2020: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
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| Outline of Final Research Achievements |
The generation of high-density lipoprotein (HDL) plays a crucial role in removing surplus cholesterol from cells, thereby preventing coronary artery disease. ATP-binding cassette protein A1 (ABCA1) is key in initiating nascent HDL generation. However, the mechanism behind ABCA1's role remains unclear. This researcher successfully replicated the phenomenon in vitro and directly visualized the process of ABCA1-mediated nascent HDL generation by capturing a side view of ABCA1 embedded in a lipid nanodisc using high-speed atomic force microscopy.
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