| Budget Amount *help |
¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2023: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2022: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2021: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2020: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
|
|---|
| Outline of Final Research Achievements |
Protein functions are regulated by a variety of post-translational modification: however, histidine methylation remains largely unclear. In this study, we investigated the regulatory mechanism of molecular function and physiological role of METTL9 that we have newly identified as histidine methyltransferase. Unexpectedly, we found that METTL9 is a target of N-linked glycosylation and thereby secreted to extracellular space.
|
